Diagnostic Significance of β-Collagen Degradation Products and Osteocalcin in Chronic Obstructive Pulmonary Disease Complicated with Osteoporosis

2021 ◽  
Vol 20 (2) ◽  
pp. 288-292
Author(s):  
Yafeng Ji ◽  
Hongliang Gao ◽  
Yongli Wang ◽  
Xuesheng Jiang
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Degradation Products ◽  
Collagen Degradation ◽  
Chronic Obstructive ◽  
Characteristic Analysis ◽  
Mineral Density ◽  
Obstructive Pulmonary Disease ◽  
Predictive Values ◽  
Collagen Degradation Products

Chronic obstructive pulmonary disease is a pulmonary dysfunction common to the middle-aged and elderly population. About 20–60% of patients with moderate or severe chronic obstructive pulmonary disease suffer from different degrees of osteoporosis. A strong relationship between β-collagen degradation products and osteocalcin has been shown in several bone diseases, but their roles in chronic obstructive pulmonary disease remain to be investigated. This study was designed to explore such a relationship in patients with chronic obstructive pulmonary disease complicated with osteoporosis. The β-collagen degradation products were the highest in the serum of patients diagnosed with both chronic obstructive pulmonary disease and osteoporosis followed by those with chronic obstructive pulmonary disease only and osteoporosis only. According to the receiver operating characteristic analysis curves, both β-collagen degradation products and osteocalcin had favorable predictive values for patients with chronic obstructive pulmonary disease, osteoporosis or both. In addition, β-collagen degradation products were negatively correlated with forced expiratory volume in 1 s and bone mineral density, while osteocalcin was positively correlated with them. β-collagen degradation products increase, and osteocalcin decreases in patients with both chronic obstructive pulmonary disease and osteoporosis.

scholarly journals Cortical bone dynamics, strength, and densitometry after induction of emphysema in hamsters

2003 ◽  
Vol 95 (2) ◽  
pp. 631-634 ◽  
Author(s):  
Jill E. Shea ◽  
Scott C. Miller ◽  
David C. Poole ◽  
John P. Mattson
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Bone Formation ◽  
Cortical Bone ◽  
Pulmonary Disease ◽  
Bone Mineral ◽  
Bone Structure ◽  
Chronic Obstructive ◽  
Pathophysiological Mechanism ◽  
Mineral Density ◽  
Obstructive Pulmonary Disease

Recent evidence suggests that patients suffering from chronic obstructive pulmonary disease are also at an increased risk of developing osteoporosis. The pathophysiological mechanism(s) linking these progressive diseases is unknown. The goal of this investigation was to determine whether there were alterations in bone mineral density and content, cortical bone structure and strength, and indexes of bone formation and resorption in the elastase-induced emphysematous hamster. At 3 wk after induction of emphysema, the femoral bone mineral content was 8% less ( P = 0.026) and the femoral fracture strength was 6% less ( P = 0.032) in the emphysematous hamster than in controls. The cortical area was 8.4% less ( P = 0.013) and the periosteal mineral appositional rate was 27% less ( P = 0.05) than in controls. Additionally, the endocortical eroded surface in the emphysematous group was about twice that in the control group ( P = 0.003). Differences in some indexes of bone formation and resorption, paralleled by differences in bone structure and strength, were observed 3 wk after induction of emphysema. These differences in skeletal metabolism and strength may help explain some of the skeletal changes associated with chronic obstructive pulmonary disease in humans.

Association of Bone Mineral Density, Parameters of Bone Turnover, and Body Composition in Patients With Chronic Obstructive Pulmonary Disease

2012 ◽  
Vol 15 (2) ◽  
pp. 217-223 ◽  
Author(s):  
Georgios A. Fountoulis ◽  
Markos Minas ◽  
Panagiotis Georgoulias ◽  
Ioannis V. Fezoulidis ◽  
Konstantinos I. Gourgoulianis ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Chronic Obstructive Pulmonary Disease ◽  
Body Composition ◽  
Bone Turnover ◽  
Pulmonary Disease ◽  
Bone Mineral ◽  
Chronic Obstructive ◽  
Mineral Density ◽  
Obstructive Pulmonary Disease
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