Elastin and collagen degradation products in urine of smokers with and without chronic obstructive pulmonary disease.

Chronic obstructive pulmonary disease is a pulmonary dysfunction common to the middle-aged and elderly population. About 20–60% of patients with moderate or severe chronic obstructive pulmonary disease suffer from different degrees of osteoporosis. A strong relationship between β-collagen degradation products and osteocalcin has been shown in several bone diseases, but their roles in chronic obstructive pulmonary disease remain to be investigated. This study was designed to explore such a relationship in patients with chronic obstructive pulmonary disease complicated with osteoporosis. The β-collagen degradation products were the highest in the serum of patients diagnosed with both chronic obstructive pulmonary disease and osteoporosis followed by those with chronic obstructive pulmonary disease only and osteoporosis only. According to the receiver operating characteristic analysis curves, both β-collagen degradation products and osteocalcin had favorable predictive values for patients with chronic obstructive pulmonary disease, osteoporosis or both. In addition, β-collagen degradation products were negatively correlated with forced expiratory volume in 1 s and bone mineral density, while osteocalcin was positively correlated with them. β-collagen degradation products increase, and osteocalcin decreases in patients with both chronic obstructive pulmonary disease and osteoporosis.

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Elastin and Collagen Degradation Products in Urine of Smokers With and Without Chronic Obstructive Pulmonary Disease

American Journal of Respiratory and Critical Care Medicine ◽

10.1164/ajrccm/151.4.952 ◽

1995 ◽

Vol 151 (4) ◽

pp. 952-959

Author(s):

Phillip J. Stone ◽

Daniel J. Gottlieb ◽

George T. O'Connor ◽

David E. Ciccolella ◽

Raphael Breuer ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Degradation Products ◽

Collagen Degradation ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Collagen Degradation Products

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Hemostatic system in chronic obstructive pulmonary disease with concomitant obesity

Bukovinian Medical Herald ◽

10.24061/2413-0737.xviii.3.71.2014.154 ◽

2014 ◽

Vol 18 (3 (71)) ◽

Author(s):

A. Y. Stupnytska

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Disseminated Intravascular Coagulation ◽

Degradation Products ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Hemostatic System ◽

Prolonged Retention ◽

Early Degradation ◽

Positive Results

The examination of patients with chronic obstructive pulmonary disease with concomitant obesity established the presence of hypercoagulable changes, the severity of which depended on its degree. All this, along with the positive results of paracoagulation samples, increasing of soluble fibrin monomer complexes and early degradation products of fibrinogen in the blood, suggest the presence of chronic disseminated intravascular coagulation with prolonged retention of hypercoagulable in such pathology.

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Serological Investigation of the Collagen Degradation Profile of Patients with Chronic Obstructive Pulmonary Disease or Idiopathic Pulmonary Fibrosis

Biomarker Insights ◽

10.4137/bmi.s9415 ◽

2012 ◽

Vol 7 ◽

pp. BMI.S9415 ◽

Cited By ~ 53

Author(s):

Diana J. Leeming ◽

Jannie M. Sand ◽

Mette J. Nielsen ◽

Federica Genovese ◽

Fernando J. Martinez ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Idiopathic Pulmonary Fibrosis ◽

Pulmonary Fibrosis ◽

Pulmonary Disease ◽

Collagen Degradation ◽

Chronic Obstructive ◽

Type Iii Collagen ◽

Type I ◽

Operating Characteristics ◽

Obstructive Pulmonary Disease

In both chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), abnormally high collagen remodeling occurs within the lung tissue. Matrix metalloproteinase (MMP)-degraded type I, III, IV, V and VI collagen and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-degraded type III collagen were assessed in serum of patients diagnosed with mild COPD (n= 10) or IPF (n= 30), and healthy controls (n= 15). The collagen degradation markers C1M, C3M, C5M and C6M were significantly elevated in serum of both mild COPD and IPF patients, versus controls. C3A and C4M were only elevated in patients with mild COPD, compared with controls. The most reliable indicators of mild COPD versus controls were: C1M (area under the receiver-operating characteristics (AUROC = 0.94, P < 0.0001), C3M (AUROC = 0.95, P < 0.0001), and C5M (AUROC = 0.95, P < 0.0001). The most reliable markers for the diagnosis of IPF were achieved by C1M (AUROC = 0.90, P < 0.0001) and C3M (AUROC = 0.93, P < 0.0001). Collagen degradation was highly up-regulated in patients with IPF and mild COPD, indicating that degradation fragments of collagens are potential markers of pulmonary diseases. Interestingly, C4M and C3A were only elevated in patients with mild COPD, indicating that these markers could be used to distinguish between the two pathologies.

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Oral and Oropharyngeal Sensory Function in Adults With Chronic Obstructive Pulmonary Disease

American Journal of Speech-Language Pathology ◽

10.1044/2019_ajslp-19-00095 ◽

2020 ◽

Vol 29 (2) ◽

pp. 864-872

Author(s):

Fernanda Borowsky da Rosa ◽

Adriane Schmidt Pasqualoto ◽

Catriona M. Steele ◽

Renata Mancopes

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Oral Cavity ◽

Pulmonary Disease ◽

Thermal Sensation ◽

Sensory Function ◽

Control Group ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Age Related ◽

Copd Patients

Introduction The oral cavity and pharynx have a rich sensory system composed of specialized receptors. The integrity of oropharyngeal sensation is thought to be fundamental for safe and efficient swallowing. Chronic obstructive pulmonary disease (COPD) patients are at risk for oropharyngeal sensory impairment due to frequent use of inhaled medications and comorbidities including gastroesophageal reflux disease. Objective This study aimed to describe and compare oral and oropharyngeal sensory function measured using noninstrumental clinical methods in adults with COPD and healthy controls. Method Participants included 27 adults (18 men, nine women) with a diagnosis of COPD and a mean age of 66.56 years ( SD = 8.68). The control group comprised 11 healthy adults (five men, six women) with a mean age of 60.09 years ( SD = 11.57). Spirometry measures confirmed reduced functional expiratory volumes (% predicted) in the COPD patients compared to the control participants. All participants completed a case history interview and underwent clinical evaluation of oral and oropharyngeal sensation by a speech-language pathologist. The sensory evaluation explored the detection of tactile and temperature stimuli delivered by cotton swab to six locations in the oral cavity and two in the oropharynx as well as identification of the taste of stimuli administered in 5-ml boluses to the mouth. Analyses explored the frequencies of accurate responses regarding stimulus location, temperature and taste between groups, and between age groups (“≤ 65 years” and “> 65 years”) within the COPD cohort. Results We found significantly higher frequencies of reported use of inhaled medications ( p < .001) and xerostomia ( p = .003) in the COPD cohort. Oral cavity thermal sensation ( p = .009) was reduced in the COPD participants, and a significant age-related decline in gustatory sensation was found in the COPD group ( p = .018). Conclusion This study found that most of the measures of oral and oropharyngeal sensation remained intact in the COPD group. Oral thermal sensation was impaired in individuals with COPD, and reduced gustatory sensation was observed in the older COPD participants. Possible links between these results and the use of inhaled medication by individuals with COPD are discussed.

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