Synthesis and Characterization of Some New 2-Hydroxy-N-(3-Trifluoromethyl-Phenyl)-Benzamide Derivatives

2008 ◽  
Vol 59 (1) ◽  
pp. 56-60
Author(s):  
Ioana M.c. Ienascu ◽  
Alfa X. Lupea ◽  
Iuliana M. Popescu ◽  
Stefan Th. Tomas ◽  
Alina D. Zamfir
Keyword(s):  
Acetic Acid ◽  
Ethyl Ester ◽  
13C Nmr ◽  
Acid Ethyl Ester ◽  
Synthesis And Characterization ◽  
Chemical Methods ◽  
Physico Chemical ◽  
New Compounds ◽  
Benzamide Derivatives

In the reaction between 2-hydroxy-N-(3-trifluoromethyl-phenyl)-benzamide and chloro-acetic acid ethyl ester, [2-(3-trifluoromethyl-phenylcarbamoyl)-phenoxy]-acetic acid ethyl ester was obtained. The ethyl ester was condensed with hydrazine giving 2-hydrazinocarbonylmethoxy-N-(3-trifluoromethyl-phenyl)-benzamide. This hydrazide is considered the key intermediate for the synthesis of new compounds. So, in the reaction between hydrazide and chloro-substituted benzaldehydes hydrazones were obtained. In order to establish their structures, all new synthesized compounds were analyzed by modern physico-chemical methods (FTIR, 1H-NMR, 13C-NMR, MS).

scholarly journals Synthesis and Characterization of N-(3-(8-Bromoimidazo[1, 2-a] pyridin-2-yl)-4-Fluorophenyl)Benzamide Derivatives

2017 ◽  
Author(s):  
Parameshwar Achugatla ◽  
Majid Ghashang ◽  
S. Guhanathan
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Synthesis And Characterization ◽  
Ms Analysis ◽  
The Family ◽  
Ft Ir ◽  
New Compounds ◽  
Benzamide Derivatives

We report here the synthesis and characterization of new N-(3-(8-bromoimidazo[1, 2-a]pyridin-2-yl)-4-fluorophenyl)benzamide derivatives. This collection was obtained from 3-(8-bromoimidazo [1,2-a]pyridin-2-yl)-4-fluoroaniline(5). The family of new compounds was characterized by 1H-NMR, 13C-NMR, FT-IR and LC-MS analysis.

scholarly journals New Synthetic Routes for 1-Benzyl-1,4,7,10-tetraazacyclododecane and 1,4,7,10-Tetraazacyclododecane-1-acetic Acid Ethyl Ester, Important Starting Materials for Metal-coded DOTA-Based Affinity Tags

2007 ◽  
Vol 62 (3) ◽  
pp. 397-406 ◽  
Author(s):  
Stephan W. Kohl ◽  
Katharina Kuse ◽  
Markus Hummert ◽  
Herbert Schumann ◽  
Clemens Mügge ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Ethyl Ester ◽  
Nmr Spectra ◽  
Acid Ethyl Ester ◽  
Affinity Tags ◽  
X Ray ◽  
H Nmr ◽  
Synthetic Routes ◽  
New Compounds ◽  
C Nmr

Two improved routes to synthesize 1-benzyl-1,4,7,10-tetraazacyclododecane (6) and 1,4,7,10- tetraazacyclododecane-1-acetic acid ethyl ester (11) are described as well as the synthesis of 1-{2-[4-(maleimido-N-propylacetamidobutyl)amino]-2-oxoethyl}-1,4,7,10-tetraazacyclododecane- 4,7,10-triacetic acid (17) and its Y, Ho, Tm, and Lu complexes. The 1H and 13C NMR spectra of the new compounds as well as the single crystal X-ray structure analyses of the intermediates 4-benzyl-1,7-bis(p-toluenesulfonyl)diethylenetriamine (3) and 1,4,7-tris(p-toluenesulfonyl)diethylenetriamine (7) are reported and discussed. The rare earth complexes of 17 have been characterized by 1H NMR spectroscopy and MALDI-TOF mass spectrometry.

scholarly journals Synthesis and Characterization of Some New Benzimidazole Derivatives

2016 ◽  
Vol 13 (1) ◽  
pp. 82-88
Author(s):  
Baghdad Science Journal
Keyword(s):  
Acetic Acid ◽  
Mannich Base ◽  
Condensation Reaction ◽  
Aromatic Aldehydes ◽  
Secondary Amines ◽  
Synthesis And Characterization ◽  
Benzimidazole Derivatives ◽  
Schiff Base Derivatives ◽  
New Compounds

In this paper the new starting material 2-(5-chloro-1H-benzo[d]imidazole-2-yl) aniline (1) was synthesized by the condensation reaction of 4-chloro-o-phenylenediamine and anthranilic acid .The new Mannich base derivatives were synthesized using formaldehyde and different secondary amines to synthesize a new set of benzimidazole derivatives(2-5). Also, the new Schiff-base derivatives (6-10) were synthesized from the reaction of compound (1) with various aromatic aldehydes and the closure-ring was done successfully using mercapto acetic acid to get the new thiazolidine derivatives(11-12).These new compounds were characterized using some physical techniques like:FT-IR Spectra and 1HNMR Spectra.

scholarly journals Synthesis and Characterization of Five, Sevene Heterocyclic Membered Rings

2013 ◽  
Vol 10 (3) ◽  
pp. 803-817
Author(s):  
Baghdad Science Journal
Keyword(s):  
Biological Activity ◽  
Schiff Bases ◽  
13C Nmr ◽  
Starting Material ◽  
Synthesis And Characterization ◽  
Melting Points ◽  
Vis Spectroscopy ◽  
Ft Ir ◽  
New Compounds

New compounds containing heterocyclic units have been synthesized. These compounds include 2-amino 5- phenyl-1,3,4-thiadiazole (1) as starting material to prepare the Schiff bases 2N[3-nitrobenzylidene -2 hydroxy benzylidene and 4-N,N-dimethyl aminobenzylidene] -5-phenyl-1,3,4-thiadiazole (2abc) , 2N[3-nitrophenyl, 2-hydroxyphenyl or 4-N,N-dimethylaminophenyl] 3-]2-amino-5-phenyl-1,3,4-thiadiazole]-2,3-dihydro-[1,3]oxazepine-benzo-4,7-dione] (3abc), 2N[3-nitrophenyl,2-hydroxyphenyl,4-N,N-dimethylaminophenyl]-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine-4,7-dione[(4abc), 2-N-[3-nitrophenyl, 2-hydroxyphenyl or 4-N,N-dimethylaminophenyl]-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2yl]-1,2,3-trihydro-benzo-[1,2-e][1,3] diazepine-4,7-dione (5abc) ,2N[2-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)]-4-oxo-1,3-thiazolidine-3-yl]-2-amino-5-phenyl-1,3,4-thiadiazole (6abc), 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-tetrazolo-1-yl]-2-amino-5-phenyl-1,3,4-thiadiazole (7abc) , 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine-benzo-4,7-dithione (8abc) , 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine -4,7-dithione -5-ene (9abc) and 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl] -1,2,3-trihydro-benzo-[1,2-e][1,3] diazepine -4,7-dithione - (10abc) . the structures of these compounds were characterized by FT-IR, 1H,13C-NMR,Uv/vis spectroscopy and the melting points were determined besides the evaluation of its biological activity.

Synthesis, Characterization and Biological Activity of the Manganese Complexes with alfa-ketoglutaric Acid and 1-0(o-tolyl) Biguanide

2017 ◽  
Vol 68 (10) ◽  
pp. 2209-2214
Author(s):  
Madalina Mihalache ◽  
Ovidiu Oprea ◽  
Cornelia Guran ◽  
Ioana Lavinia Ardelean
Keyword(s):  
Staphylococcus Aureus ◽  
Cytotoxic Effect ◽  
Nir Spectroscopy ◽  
Molar Conductivity ◽  
Manganese Complexes ◽  
Synthesis And Characterization ◽  
Bacterial Strains ◽  
Chemical Methods ◽  
Physico Chemical

This paper presents the synthesis and characterization of three complexes of Mn (II,III), with the a-ketoglutaric acid (H2A) and 1- (o-tolyl) biguanide (TB) as ligands. The complexes corresponding formulas are: [Mn(TB)2(H2A)]Cl2 . 0.5C2H5OH (C1), [Mn2(TB)(A)(H2A)2(H2O)2(NO3)2](NO3)2. C2H5OH (C2) and [Mn2(TB)(A)(H2A)2(H2O)2(CH3COO)2](CH3COO)2 . 3H2O (C3), where A is H2A without 2 protons. C1-C3 compounds were characterized by standard physico-chemical methods: chemical elemental analysis, IR spectroscopy, UV-Vis-NIR spectroscopy, molar conductivity and thermal analysis. For the obtained C1-C3 complexes, but also for the ligands (H2A and TB) was tested the antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853 and antitumor activity on HeLa tumour cells. It has been observed a moderate cytotoxic effect of the complexes C1-C3 on growth and metabolic activity of HeLa cells, while the ligands show a very weak effect on them. The obtained complexes inhibits the adhesion on the substrate of bacterial strains Staphylococcus aureus and Pseudomona aeruginosa, which recommends them for possible therapeutic applications.

scholarly journals Synthesis and characterization of some heterocyclic including oxazoles,Thiazoles, Pyridazines, phthalizines and Pyrazoles with evaluating of biological activity.

2013 ◽  
Vol 10 (3) ◽  
pp. 818-827
Author(s):  
Baghdad Science Journal
Keyword(s):  
Acetic Acid ◽  
Biological Activity ◽  
Nmr Spectroscopy ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Acid Hydrazide ◽  
Synthesis And Characterization ◽  
Ft Ir ◽  
New Compounds

A series of new compounds including p-bromo methyl pheno acetate [2]. N-( aminocarbonyl)–p-bromo pheno acetamide [3] , N-( aminothioyl) -p-bromo phenoacetyl amide [4], N-[4-(p-di phenyl)-1,3-oxazol-2-yl]-p-bromopheno acetamide [5],N-[4-p-di phenyl]-1,3-thiazol-2-yl-p-bromo phenoacet amide [6], p-bromopheno acetic acid hydrazide [7] , 1-N-(p-bromo pheno acetyl)-1,2-dihydro-pyridazin-3,6- dione [8], 1-N-(p-bromo pheno acetyl)-1,2-dihydro-phthalazin-3,8- dione[ 9], 1-(p-bromo pheno acetyl)-3-methylpyrazol-5-one [10] and 1-(p-bromo phenol acetyl)- 3,5-dimethyl pyrazole [11] have been synthesized. The prepared compounds were characterized by m.p.,FT-IR and 1H-NMR spectroscopy. Also ,the biological activity was evaluated .

Synthesıs and Characterızatıon of New Trıazole and Coumarın-Derived Heterocyclıc Compounds Part I

2019 ◽  
Vol 41 (6) ◽  
pp. 1097-1097
Author(s):  
Nurhan G mr k o lu Nurhan G mr k o lu ◽  
Muhammad Imran and Inam Iqbal Muhammad Imran and Inam Iqbal
Keyword(s):  
Acetic Acid ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Heterocyclic Compounds ◽  
Acid Hydrazide ◽  
Triazole Ring ◽  
Basic Medium ◽  
Synthesis And Characterization ◽  
Ethyl Bromoacetate

Synthesis of ethyl ester of acetic acid containing 5-oxo-[1,2,4] triazole ring (2) was achieved by the condensation of 3-substituted-4-amino-1H-1,2,4-triazol-5(4H)-one (1) with ethyl bromoacetate in basic medium. Compound 2, was then further reacted with hydrazine hydrate to form acid hydrazide, which is 2-(4-amino-3-substituted-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)acetohydrazide (3). Compound 3 was later treated with three different diverse coumarin aldehydes (6, 12, 18) resulted in the formation of arylidene hydrazides as cis–trans conformers (7, 8, 13, 14, 19, 20). In conclusion, we synthesized 1,2,4-triazole Schiff bases derived from the condensation of 3-substituted-4-amino-1,2,4-triazole-5-on and formylhydroxy-4-methylcoumarin derivatives, which have been characterized by, spectroscopic measurements (IR, 1H-NMR, 13C-NMR and elemental analysis).

Synthesis and Characterization of Some New Esters Containing Heterocyclic and Derived From Azo Dyes

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Zena G. Alrecabi ◽  
Zainab Amer ◽  
Naeemah Al-Lami
Keyword(s):  
Schiff Base ◽  
13C Nmr ◽  
Azo Dyes ◽  
Spectral Methods ◽  
Anthranilic Acid ◽  
Heterocyclic Compounds ◽  
Synthesis And Characterization ◽  
Cooh Group ◽  
Molecular Weights

This study including prepared new colored esters containing heterocyclic with high molecular weights. In the first part of work we synthesized azo dyes [1,2] from the reaction p-toluidine with β-naphthol and o-nitro phenol, thin we synthesized Schiff bases [3,4] by the reaction anthranilic acid with benzaldehyde and dimethyl benzaldehyde. The reaction azo dyes (contain OH group) with Schiff base (contain COOH group) these led to produce the new colored esters [A1-A4]. The second part of work was modification the (C=N-) group in esters to heterocyclic compounds by reacting with phenyl iso cyanide to produce new β-lactam [B1-B4] and with anthranilic acid to get new hydroquinazoline [C1-C4]. All these compounds were characterized by physical properties and spectral methods FTIR, 1H-NMR and 13C-NMR.

Coordination Compounds of Some 3d-Transition Metal Ions with N1-[4-(4-bromo-phenylsulfonyl)-benzoyl]-N4-(4-methoxyphenyl)- thiosemicarbazide

2008 ◽  
Vol 59 (7) ◽  
Author(s):  
Madalina Angelusiu ◽  
Maria Negoiu ◽  
Stefania-Felicia Barbuceanu ◽  
Tudor Rosu
Keyword(s):  
Coordination Compounds ◽  
Magnetic Moments ◽  
Thermo Gravimetric Analysis ◽  
Electronic Spectroscopy ◽  
Transition Metal Ions ◽  
Synthesis And Characterization ◽  
Gravimetric Analysis ◽  
Thermo Gravimetric ◽  
New Compounds

The paper presents the synthesis and characterization of Cu(II), Co(II), Ni(II), Cd(II), Zn(II) and Hg(II) complexes with N1-[4-(4-bromo-phenylsulfonyl)-benzoyl]-N4-(4-methoxyphenyl)-thiosemicarbazide. The new compounds were characterized by IR, EPR, electronic spectroscopy, magnetic moments, thermo-gravimetric analysis and elemental analysis.

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