Evaluation of Liver Chemistry Tests and Clinical Parameters in Patients with Periodontal Disease and Chronic Hepatitis C

2017 ◽  
Vol 68 (6) ◽  
pp. 1252-1254
Author(s):  
Dorin Nicolae Gheorghe ◽  
Darian Rusu ◽  
Elena Herascu ◽  
Dora Maria Popescu ◽  
Petra Surlin ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Periodontal Disease ◽  
Chronic Hepatitis C ◽  
Inflammatory Markers ◽  
Metabolic Markers ◽  
Periodontal Inflammation ◽  
Positive Correlations ◽  
Periodontal Medicine ◽  
Gingival Fluid

The concept of periodontal medicine has been created by taking into consideration the strong connection between the development of the periodontal disease and other general conditions. The presence in blood, saliva and gingival fluid of certain inflammatory markers that are common for the two conditions � periodontitis and chronic hepatitis C, that can generate the appearance of the periodontal inflammation, can be an explication for the probable interconnection of the two conditions. The purpose of this pilot study is to investigate whether chronic hepatitis C can be a worsening factor for the development of the periodontal disease, by setting correlations between the periodontal pathology and some metabolic markers of both hepatitis C and periodontitis patients in comparison to periodontitis-only ones. Positive correlations would justify the expansion of the study for a larger group of patients and the dosage of inflammatory markers for biologic fluids such as blood, saliva and gingival fluid.

scholarly journals NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Petra Surlin ◽  
Luminita Lazar ◽  
Cerasella Sincar ◽  
Dorin Nicolae Gheorghe ◽  
Dora Maria Popescu ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Periodontal Disease ◽  
Chronic Hepatitis C ◽  
Inflammatory Reaction ◽  
Nlrp3 Inflammasome ◽  
Gingival Crevicular Fluid ◽  
Periodontal Status ◽  
Local Inflammatory Reaction ◽  
Crevicular Fluid

The study is aimed at assessing the impact that periodontal disease and chronic hepatitis C could have on gingival crevicular fluid levels of the NLRP3 inflammasome, caspase-1 (CASP-1), and interleukin-18 (IL-18) and at evaluating whether the increased local inflammatory reaction with clinical periodontal consequences is correlated to their upregulation. Patients were divided into four groups, according to their periodontal status and previously diagnosed hepatitis C, as follows: (i) CHC group, chronic hepatitis C patients; (ii) P group, periodontal disease patients, systemically healthy; (iii) CHC + P group, patients suffering from both conditions; and (iv) H group, systemically and periodontally healthy controls. Gingival crevicular samples were collected for quantitative analysis of the NLRP3 inflammasome, CASP-1, and IL-18. CHC + P patients expressed the worse periodontal status and the highest NLRP3, CASP-1, and IL-18 levels, the difference being statistically significant ( p < 0.05 ). The P group patients also expressed significantly more elevated NLRP3, CASP-1, and IL-18 levels, as compared to nonperiodontal patients (CHC and H groups). Chronic hepatitis C and periodontal disease could have a significant influence on the upregulation of NLRP3 inflammasome and its components, possibly contributing to an increased local inflammatory reaction and clinical periodontal consequences.

scholarly journals Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C

2021 ◽  
Vol 10 (22) ◽  
pp. 5275
Author(s):  
Dorin Nicolae Gheorghe ◽  
Dora Maria Popescu ◽  
Alex Salan ◽  
Mihail Virgil Boldeanu ◽  
Claudiu Marinel Ionele ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Periodontal Therapy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Clinical Parameters ◽  
Periodontal Status ◽  
The Impact ◽  
Gingival Fluid ◽  
Chronic Hepatitis C Patients

Non-surgical periodontal therapy (NSPT) is the first essential step for the management of any periodontitis patient. This study aims to evaluate the impact of NSPT on pro-inflammatory mediators’ regulation and on clinical parameters in periodontitis patients who suffer from chronic hepatitis C. At baseline, selected patients were clinically evaluated for their periodontal status. A subsequent quantitative assessment of C-reactive protein and pentraxin-3 in samples of gingival fluid was performed by Enzyme-Linked Immunosorbent Assay (ELISA). Afterwards, NSPT was performed. Three months after NSPT, the clinical and ELISA assessments were repeated. The results show an improvement of the clinical parameters in periodontitis patients at the three-month recall. In chronic hepatitis C patients with periodontitis, the gingival fluid levels of pro-inflammatory markers reduced significantly. The targeted markers also expressed significant correlations with the clinical parameters used for the assessment of periodontitis’ severity. The results suggest that, while chronic hepatitis C patients exhibited a more negative periodontal status at baseline as compared to non-hepatitis ones, NSPT is effective in decreasing the local periodontal inflammatory reaction and in proving the periodontal status of this type of patients. Given the limitation of the study, periodontal screening and NSPT should be included in the integrated therapeutical approach of chronic hepatitis C patients, for its impact on the local inflammatory response.

Inflammatory markers in chronic hepatitis C

1997 ◽  
Vol 431 (3) ◽  
pp. 181-187 ◽  
Author(s):  
B. F. Banner ◽  
C. Allan ◽  
L. Savas ◽  
S. Baker ◽  
G. Barnard ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Inflammatory Markers

scholarly journals Obesity and steatosis influence serum and hepatic inflammatory markers in chronic hepatitis C

Hepatology ◽  
2008 ◽  
Vol 48 (1) ◽  
pp. 80-87 ◽  
Author(s):  
Julie R. Jonsson ◽  
Helen D. Barrie ◽  
Peter O'Rourke ◽  
Andrew D. Clouston ◽  
Elizabeth E. Powell
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Inflammatory Markers

scholarly journals Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C

2009 ◽  
Vol 13 (5) ◽  
pp. 375-382 ◽  
Author(s):  
Alexandre Sampaio Moura ◽  
Ricardo Andrade Carmo ◽  
Antonio Lucio Teixeira ◽  
Manoel Otávio da Costa Rocha
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Inflammatory Markers ◽  
Therapeutic Response ◽  
Hepatocellular Damage

Lichen myxedematosus associated with chronic hepatitis C

2000 ◽  
Vol 39 (3) ◽  
pp. 212-214 ◽  
Author(s):  
Hiroyuki Banno ◽  
Hiromichi Takama ◽  
Yukiko Nitta ◽  
Toshihiko Ikeya ◽  
Yoshifumi Hirooka
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Lichen Myxedematosus
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