Comparative Study by Analytical Multidisciplinary Methods and Oxidative Stress in Breast Cancer Diagnosis

2018 ◽  
Vol 69 (8) ◽  
pp. 2254-2259
Author(s):  
Irina Jari ◽  
Alexandru Naum ◽  
Liliana Gheorghe Moisii ◽  
Cipriana Stefanescu ◽  
Dragos Negru ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Cancer Diagnosis ◽  
Gold Standard ◽  
Breast Imaging ◽  
Diagnostic Performance ◽  
Area Under The Curve ◽  
Breast Mri ◽  
Breast Cancer Diagnosis ◽  
And Oxidative Stress

To evaluate the diagnostic performance of mammography, elastography and breast magnetic resonance imaging (MRI), as tools for breast cancer diagnosis, against pathological diagnosis as the gold standard. Other risk factors such as obesity and oxidative stress are also disccused. In this comparison study, a total of 169 female patients (mean age 51 years, range 35-77 years) were enrolled between January 2016 and June 2017. After the physical examination of the breasts, patients were further randomized into three groups to mammography, elastography, or breast MRI. Only women with detected lesions classified into breast imaging and reporting data system (BI-RADS) category or Tsukuba elasticity score from 2 to 5 were included. Histopathology was used as the gold standard for diagnosis. The diagnostic performance of each modality was calculated. Of a total of 50 pathologically confirmed cancers, 25 were detected by mammography, 11 by elastography, and 14 by breast MRI, which resulted in sensitivities of 84% (PPV = 78%), 75% (PPV = 64%) and 86% (PPV = 75%), respectively. Mammography, elastography, and breast MRI led to 6, 5, and 4 false positive findings, which resulted in specificities of 86% (NPV = 90%), 87% (NPV = 92%) and 89% (NPV = 94%), respectively. The area under the curve (AUC) values for the mammography, elastography and breast MRI were 0.849 (95% CI, 0.758-0.939), 0.809 (95% CI, 0.670-0.948) and 0.876 (95% CI, 0.769-0.983). The DOR values were 32 (95% CI, 8-125), 20 (95% CI, 4-99) and 51 (95% CI, 8-315). The breast MRI proved a slight advantage over mammography as a diagnostic tool in breast cancer diagnosis.

scholarly journals Tamoxifen and oxidative stress: an overlooked connection

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Nermin S. Ahmed ◽  
Marek Samec ◽  
Alena Liskova ◽  
Peter Kubatka ◽  
Luciano Saso
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Gold Standard ◽  
Pharmacological Activities ◽  
Standard Drug ◽  
Menopausal Women ◽  
Wide Range ◽  
Post Menopausal ◽  
Apoptotic Effects ◽  
And Oxidative Stress

AbstractTamoxifen is the gold standard drug for the treatment of breast cancer in pre and post-menopausal women. Its journey from a failing contraceptive to a blockbuster is an example of pharmaceutical innovation challenges. Tamoxifen has a wide range of pharmacological activities; a drug that was initially thought to work via a simple Estrogen receptor (ER) mechanism was proven to mediate its activity through several non-ER mechanisms. Here in we review the previous literature describing ER and non-ER targets of tamoxifen, we highlighted the overlooked connection between tamoxifen, tamoxifen apoptotic effects and oxidative stress.

Breast Cancer Diagnosis With Mammography

2021 ◽  
pp. 107-127
Author(s):  
Abir Baâzaoui ◽  
Walid Barhoumi
Keyword(s):  
Breast Cancer ◽  
Cancer Diagnosis ◽  
Gold Standard ◽  
Breast Cancer Diagnosis ◽  
Black Box ◽  
Diagnose Breast Cancer ◽  
Cad Systems ◽  
Helpful Tool ◽  
Cancerous Lesion ◽  
Aided Diagnosis

Breast cancer, which is the second-most common and leading cause of cancer death among women, has witnessed growing interest in the two last decades. Fortunately, its early detection is the most effective way to detect and diagnose breast cancer. Although mammography is the gold standard for screening, its difficult interpretation leads to an increase in missed cancers and misinterpreted non-cancerous lesion rates. Therefore, computer-aided diagnosis (CAD) systems can be a great helpful tool for assisting radiologists in mammogram interpretation. Nonetheless, these systems are limited by their black-box outputs, which decreases the radiologists' confidence. To circumvent this limit, content-based mammogram retrieval (CBMR) is used as an alternative to traditional CAD systems. Herein, authors systematically review the state-of-the-art on mammography-based breast cancer CAD methods, while focusing on recent advances in CBMR methods. In order to have a complete review, mammography imaging principles and its correlation with breast anatomy are also discussed.

scholarly journals Costs of diagnostic and preoperative workup with and without breast MRI in older women with a breast cancer diagnosis

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Tracy Onega ◽  
Anna N.A. Tosteson ◽  
Julie Weiss ◽  
Jennifer Alford-Teaster ◽  
Rebecca A. Hubbard ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Older Women ◽  
Cancer Diagnosis ◽  
Breast Mri ◽  
Breast Cancer Diagnosis ◽  
Preoperative Workup

scholarly journals Exploring the Association between Demographic Factors and Breast Cancer Diagnosis at a Holistic Breast Imaging Clinic in Cairo, Egypt

2020 ◽  
Vol 4 (1) ◽  
pp. 7-12
Author(s):  
Hanan S. Gewefel ◽  
◽  
Sophia Michelen ◽  
Bodour Salhia ◽  
Iman Ewais ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Diagnosis ◽  
Breast Imaging ◽  
Demographic Factors ◽  
Breast Cancer Diagnosis

scholarly journals Detection of TP53 and PIK3CA Mutations in Circulating Tumor DNA Using Next-Generation Sequencing in the Screening Process for Early Breast Cancer Diagnosis

2019 ◽  
Vol 8 (8) ◽  
pp. 1183 ◽  
Author(s):  
Rodriguez ◽  
Córdoba ◽  
Aranda ◽  
Álvarez ◽  
Vicioso ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Cancer Diagnosis ◽  
Breast Imaging ◽  
Breast Cancer Diagnosis ◽  
Circulating Tumor Dna ◽  
Sequencing Analysis ◽  
Pik3ca Mutations ◽  
Ctdna Analysis ◽  
Tumor Dna

Circulating tumor DNA (ctDNA) has emerged as a non-invasive “liquid biopsy” for early breast cancer diagnosis. We evaluated the suitability of ctDNA analysis in the diagnosis of early breast cancer after mammography findings, comparing PIK3CA and TP53 mutations between tumor biopsies and pre-biopsy circulating DNA. Matched plasma and frozen fresh tissue biopsies from patients with Breast Imaging-Reporting and Data System (BIRADS) 4c/5 mammography findings and subsequent diagnosis of primary breast cancer were analyzed using NGS TruSeq Custom Amplicon Low Input Panel (Illumina) and plasma SafeSEQ (Sysmex Inostics). The same plasma and tumor mutations were observed in eight of 29 patients (27.6%) with four in TP53 and five in PIK3CA mutations. Sequencing analysis also revealed four additional ctDNA mutations (three in TP53 and one in PIK3CA) previously not identified in three patients tissue biopsy. One of these patients had mutations in both genes. Age, tumor grade and size, immunohistochemical (IHC) subtype, BIRADS category, and lymph node positivity were significantly associated with the detectability of these blood tumor-derived mutations. In conclusion, ctDNA analysis could be used in early breast cancer diagnosis, providing critical clinical information to improve patient diagnosis.

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