scholarly journals Tamoxifen and oxidative stress: an overlooked connection

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Nermin S. Ahmed ◽  
Marek Samec ◽  
Alena Liskova ◽  
Peter Kubatka ◽  
Luciano Saso
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Gold Standard ◽  
Pharmacological Activities ◽  
Standard Drug ◽  
Menopausal Women ◽  
Wide Range ◽  
Post Menopausal ◽  
Apoptotic Effects ◽  
And Oxidative Stress

AbstractTamoxifen is the gold standard drug for the treatment of breast cancer in pre and post-menopausal women. Its journey from a failing contraceptive to a blockbuster is an example of pharmaceutical innovation challenges. Tamoxifen has a wide range of pharmacological activities; a drug that was initially thought to work via a simple Estrogen receptor (ER) mechanism was proven to mediate its activity through several non-ER mechanisms. Here in we review the previous literature describing ER and non-ER targets of tamoxifen, we highlighted the overlooked connection between tamoxifen, tamoxifen apoptotic effects and oxidative stress.

Effect of 1-year dietary supplementation with vitaminized olive oil on markers of bone turnover and oxidative stress in healthy post-menopausal women

Endocrine ◽  
2015 ◽  
Vol 50 (2) ◽  
pp. 326-334 ◽  
Author(s):  
Laura Mazzanti ◽  
Maurizio Battino ◽  
Laura Nanetti ◽  
Francesca Raffaelli ◽  
Alessandro Alidori ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bone Turnover ◽  
Olive Oil ◽  
Dietary Supplementation ◽  
Menopausal Women ◽  
Markers Of Bone Turnover ◽  
Post Menopausal ◽  
And Oxidative Stress

Prostaglandin F2α metabolite and F2-isoprostane excretion rates in migraine

2001 ◽  
Vol 102 (1) ◽  
pp. 39-43 ◽  
Author(s):  
Johanna HELMERSSON ◽  
Peter MATTSSON ◽  
Samar BASU
Keyword(s):  
Oxidative Stress ◽  
Migraine Attack ◽  
Prostaglandin F2α ◽  
Urine Samples ◽  
Menopausal Women ◽  
The Mean ◽  
Post Menopausal ◽  
Excretion Rates ◽  
And Control ◽  
And Oxidative Stress

The pathophysiology theory of migraine postulates a local, neurogenic inflammation and the possible involvement of oxidative stress. We analysed the levels of 15-oxo-dihydro-prostaglandin F2α (a metabolite of prostaglandin F2α) and 8-iso-prostaglandin F2α (a major isoprostane), which are biomarkers for inflammation and oxidative stress respectively, in urine from 21 patients with migraine, with and without aura. Urine samples from migraine patients were collected during a migraine attack, and control samples were collected from the same subjects on a migraine-free morning. The mean basal levels of 15-oxo-dihydro-prostaglandin F2α and 8-iso-prostaglandin F2α in the morning control urine samples were 0.54±0.11 and 0.31±0.13nmol/mmol of creatinine respectively. The mean levels of 15-oxo-dihydro-prostaglandin F2α and 8-iso-prostaglandin F2α in the urine samples collected during the migraine attack in the 21 patients were 0.53±0.13 and 0.32±0.11nmol/mmol of creatinine respectively. Thus there were no differences in the 15-oxo-dihydro-prostaglandin F2α and 8-iso-prostaglandin F2α excretion rates during the migraine attack compared with on the migraine-free day. However, the basal 8-iso-prostaglandin F2α excretion levels on the migraine-free day were significantly lower in pre-menopausal women (0.24±0.08nmol/mmol of creatinine, n = 11) compared with post-menopausal women (0.39±0.14nmol/mmol of creatinine; n = 7; P = 0.009). In conclusion, in this study we found no support for the involvement of inflammation and oxidative stress in migraine pathophysiology. Our results indicate, however, a lower level of oxidative stress in pre-menopausal compared with post-menopausal women.

scholarly journals Role of inflammation and oxidative stress in post-menopausal oestrogen-dependent breast cancer

2014 ◽  
Vol 18 (12) ◽  
pp. 2519-2529 ◽  
Author(s):  
Clelia Madeddu ◽  
Giulia Gramignano ◽  
Carlo Floris ◽  
Giuseppe Murenu ◽  
Giuseppe Sollai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Post Menopausal ◽  
And Oxidative Stress

Comparative Study by Analytical Multidisciplinary Methods and Oxidative Stress in Breast Cancer Diagnosis

2018 ◽  
Vol 69 (8) ◽  
pp. 2254-2259
Author(s):  
Irina Jari ◽  
Alexandru Naum ◽  
Liliana Gheorghe Moisii ◽  
Cipriana Stefanescu ◽  
Dragos Negru ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Cancer Diagnosis ◽  
Gold Standard ◽  
Breast Imaging ◽  
Diagnostic Performance ◽  
Area Under The Curve ◽  
Breast Mri ◽  
Breast Cancer Diagnosis ◽  
And Oxidative Stress

To evaluate the diagnostic performance of mammography, elastography and breast magnetic resonance imaging (MRI), as tools for breast cancer diagnosis, against pathological diagnosis as the gold standard. Other risk factors such as obesity and oxidative stress are also disccused. In this comparison study, a total of 169 female patients (mean age 51 years, range 35-77 years) were enrolled between January 2016 and June 2017. After the physical examination of the breasts, patients were further randomized into three groups to mammography, elastography, or breast MRI. Only women with detected lesions classified into breast imaging and reporting data system (BI-RADS) category or Tsukuba elasticity score from 2 to 5 were included. Histopathology was used as the gold standard for diagnosis. The diagnostic performance of each modality was calculated. Of a total of 50 pathologically confirmed cancers, 25 were detected by mammography, 11 by elastography, and 14 by breast MRI, which resulted in sensitivities of 84% (PPV = 78%), 75% (PPV = 64%) and 86% (PPV = 75%), respectively. Mammography, elastography, and breast MRI led to 6, 5, and 4 false positive findings, which resulted in specificities of 86% (NPV = 90%), 87% (NPV = 92%) and 89% (NPV = 94%), respectively. The area under the curve (AUC) values for the mammography, elastography and breast MRI were 0.849 (95% CI, 0.758-0.939), 0.809 (95% CI, 0.670-0.948) and 0.876 (95% CI, 0.769-0.983). The DOR values were 32 (95% CI, 8-125), 20 (95% CI, 4-99) and 51 (95% CI, 8-315). The breast MRI proved a slight advantage over mammography as a diagnostic tool in breast cancer diagnosis.

scholarly journals Association of serum paraoxonase 1 activities, polymorphisms and oxidative stress in breast cancer patients with type 2 diabetes mellitus

2019 ◽  
Vol 38 (3) ◽  
pp. 368-375 ◽  
Author(s):  
Fatma Ceyla Eraldemir ◽  
Nihal Üren ◽  
Tuğba Kum ◽  
Burcu Erbay ◽  
Deniz Şahin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Paraoxonase 1 ◽  
Stress Index ◽  
Oxidative Stress Index ◽  
Number Of Patients ◽  
Wide Range ◽  
And Oxidative Stress

SummaryBackgroundThe aim of the study was to investigate the association of paraoxonase 1 (PON1) polymorphism, PON1/arylesterase (ARE) activity and oxidative stress index (OSI) in breast cancer (BC) patients with type 2 diabetes (DM).MethodsOur study group consisted of 30 healthy women (HV group) and 66 female BC patients. The BC patients were divided into two groups: those with (n=37) and without DM (n=29) (BDM and NBDM group). Genotyping of PON1 Q192R and L55M polymorphisms were done by polymerase chain reaction (PCR) – restriction fragment length polymorphism (RFLP) method. Serum PON1/ARE enzyme activities, total oxidant status (TOS) and total antioxidant status (TAS) were analysed by spectrophotometric method. The ratio of TOS to TAS was accepted as the oxidative stress index (OSI).ResultsPON1 Q192R genotype frequency distribution was significantly different in the BDM group compared to the NBDM group (p=0.021). When alleles distribution was examined, R and L alleles were significantly lower, Q and M alleles were significantly higher in the BDM group than in the NBDM group (p<0.001). TOS and OSI were statistically higher in BC patients than HV group (p<0.001).ConclusionsOur results suggest that PON1 gene Q and M alleles may be the risk factors predisposing formation of BC due to increased oxidant damage seen in DM. However, these statements require further confirmation with screening PON1 polymorphism in a greater number of patients with DM, and also wide range follow-up studies are necessary for the same purpose.

scholarly journals 82P Risk factors for breast cancer: A case-control study among post-menopausal women in Pakistan

2016 ◽  
Vol 27 ◽  
pp. ix24
Author(s):  
N.A. Jadoon ◽  
M. Hussain ◽  
F.U. Sulehri ◽  
A. Zafar ◽  
A. Ijaz
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Case Control Study ◽  
Case Control ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Control Study

scholarly journals Endogenous hormones and risk of invasive breast cancer in pre- and post-menopausal women: findings from the UK Biobank

2021 ◽  
Author(s):  
Sandar Tin Tin ◽  
Gillian K. Reeves ◽  
Timothy J. Key
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Invasive Breast Cancer ◽  
Cox Regression ◽  
Menopausal Status ◽  
Endogenous Hormones ◽  
Uk Biobank ◽  
Menopausal Women ◽  
Post Menopausal

Abstract Background Some endogenous hormones have been associated with breast cancer risk, but the nature of these relationships is not fully understood. Methods UK Biobank was used. Hormone concentrations were measured in serum collected in 2006–2010, and in a repeat subsample (N ~ 5000) in 2012–13. Incident cancers were identified through data linkage. Cox regression models were used, and hazard ratios (HRs) corrected for regression dilution bias. Results Among 30,565 pre-menopausal and 133,294 post-menopausal women, 527 and 2,997, respectively, were diagnosed with invasive breast cancer during a median follow-up of 7.1 years. Cancer risk was positively associated with testosterone in post-menopausal women (HR per 0.5 nmol/L increment: 1.18; 95% CI: 1.14, 1.23) but not in pre-menopausal women (pheterogeneity = 0.03), and with IGF-1 (insulin-like growth factor-1) (HR per 5 nmol/L increment: 1.18; 1.02, 1.35 (pre-menopausal) and 1.07; 1.01, 1.12 (post-menopausal); pheterogeneity = 0.2), and inversely associated with SHBG (sex hormone-binding globulin) (HR per 30 nmol/L increment: 0.96; 0.79, 1.15 (pre-menopausal) and 0.89; 0.84, 0.94 (post-menopausal); pheterogeneity = 0.4). Oestradiol, assessed only in pre-menopausal women, was not associated with risk, but there were study limitations for this hormone. Conclusions This study confirms associations of testosterone, IGF-1 and SHBG with breast cancer risk, with heterogeneity by menopausal status for testosterone.

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