Cinnarizine - Potential Trigger of the Dopamine Supersensitivity Psychosis in Patients with Paranoid Schizophrenia Particular neurobiochemical model

2019 ◽  
Vol 70 (8) ◽  
pp. 3003-3007
Author(s):  
Ileana Marinescu ◽  
Puiu Olivian Stovicek ◽  
Dragos Marinescu ◽  
Marius Toma Papacocea ◽  
Mihnea Costin Manea ◽  
...  
Keyword(s):  
Sensory Integration ◽  
Paranoid Schizophrenia ◽  
D2 Receptor ◽  
Point Of View ◽  
Cognitive Symptoms ◽  
Receptor Blocking ◽  
Clinical Reality ◽  
Potential Trigger ◽  
Dopamine Supersensitivity ◽  
Blocking Capacity

Supersensitivity psychosis is a subdiagnosed clinical reality. This entity, however, is insufficiently elucidated from the point of view of the neurobiochemical mechanisms involved in the pathogenesis. The combination of an antipsychotic with a high D2 receptor blocking capacity and a neuroleptic-like substance such as cinnarizine trigger the dopaminergic hypersensitivity mechanisms. This stimulates the sensitivity for dopamine in the prefrontal cortex, ameliorating the negative and cognitive symptoms at the thalamic level, remodeling sensory integration and decreasing tinnitus, as well as in the cerebral tonsil, consequently decreasing the risk of antisocial behavior.

Treatment of Psychogenic Polydipsia: Comparison of Risperidone and Olanzapine, and the Effects of an Adjunctive Angiotensin-II Receptor Blocking Drug (Irbesartan)

2001 ◽  
Vol 35 (1) ◽  
pp. 65-68 ◽  
Author(s):  
David Kruse ◽  
Christos Pantelis ◽  
Ray Rudd ◽  
Joy Quek ◽  
Penny Herbert ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Weight Change ◽  
Paranoid Schizophrenia ◽  
Antipsychotic Agents ◽  
Psychotic Symptoms ◽  
Behavioural Intervention ◽  
Drinking Behaviour ◽  
Blocking Drug ◽  
Angiotensin Ii Receptor ◽  
Receptor Blocking

Objective: Our objective was to determine the outcome of novel strategies in managing a case of severe polydipsia. Clinical picture: The patient was a 39-year-old male with a 20-year history of paranoid schizophrenia who, despite only mild residual psychotic symptoms, had been hospitalized for the previous 10 years because of severe polydipsic behaviour complicated by water intoxication. Treatment: Novel antipsychotic agents, risperidone and olanzapine, as well as the specific angiotensin-II receptor blocking drug, irbesartan were employed at selected intervals in a study lasting nearly 3 years. A strict behavioural management programme was ongoing, in which diurnal weight change and the number of breaches of weight limits, requiring management in a low-stimulus environment, were documented on a daily basis. Summary measures of diurnal weight change and behavioural intervention were charted against changes in treatment. Outcome: Polydipsic behaviour improved on risperidone up to 4 mg daily, but was not sustained. Olanzapine was similarly successful in stabilizing polydipsia, and improvement was achieved with the addition of irbesartan. Conclusion: We suggest that the D2-sparing profiles of receptor binding achieved with low-dose risperidone and olanzapine may account for this beneficial effect. The benefit derived with irbesartan implicates the involvement of brain angiotensin systems centrally in helping to regulate drinking behaviour.

The impacts of dopamine D2 receptor polymorphism and antipsychotic dosage on dopamine supersensitivity psychosis in schizophrenia

2017 ◽  
Vol 190 ◽  
pp. 182-183 ◽  
Author(s):  
Masayuki Takase ◽  
Nobuhisa Kanahara ◽  
Yasunori Oda ◽  
Tomihisa Niitsu ◽  
Hiroyuki Watanabe ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Dopamine Supersensitivity ◽  
Receptor Polymorphism

Valutazione del carico familiare in un campione di parenti di pazienti con diagnosi di schizofrenia paranoide: risultati preliminari

1993 ◽  
Vol 2 (1) ◽  
pp. 35-45 ◽  
Author(s):  
Franco Veltro ◽  
Lorenza Magliano ◽  
Silvana Lobrace ◽  
Pierluigi Morosini ◽  
Mario Maj
Keyword(s):  
Negative Symptoms ◽  
Paranoid Schizophrenia ◽  
Clinical Status ◽  
Leisure Activities ◽  
Great Majority ◽  
Point Of View ◽  
Perceived Burden ◽  
The Family ◽  
Psychiatric Units ◽  
Schizophrenic Patients

SummaryObjective - assessment of the burden perceived by a sample of key-relatives of schizophrenic patients. Design - Observational study of key-relatives of patients with a PSE-CATEGO diagnosis of active paranoid schizophrenia. Assessment of possible correlations between the family burden, the patients' symptoms and disabilities, as well as the relatives attitude of overinvolvement and criticism. Setting - Inpatient and outpatient psychiatric units of the Department of Psychiatry of the First Medical School, University of Naples. Subjects - 25 patients, with a diagnosis of active paranoid schizophrenia, according to ICD-9 diagnostic criteria, minimun illness history 1 year, at least one previous admission, living with at least one adult relative. Main outcome measures - Standardized assessment of patients clinical status and social disability and of relatives clinical status attitude and perceived burden. Results - The burden, both objective and subjective, was found to be present to a marked or very marked degree in more than 50% of the inteviewed relatives. A marked effect of the patients illness was observed especially on relatives social contacts and leisure activities. Also the attitudes of criticism and overinvolvement were detected in the great majority of the relatives. 52% of the relatives, when assessed by the PSE-9, received a psychiatric diagnosis. The objective burden was found to be associated with some «negative» symptoms and deficits of social functioning in the patients. Finally, significant correlations were observed between the objective and subjective dimensions of the burden and the relatives attitudes of hypercriticism toward the patients. Conclusions - The present study seems to be relevant both from the epidemiological point of view and for psychiatric care planning.

Dopamine D2 Receptor Dimers and Receptor-Blocking Peptides

1996 ◽  
Vol 227 (1) ◽  
pp. 200-204 ◽  
Author(s):  
Gordon Y.K. Ng ◽  
Brian F. O'Dowd ◽  
Samuel P. Lee ◽  
Hans T. Chung ◽  
Mark R. Brann ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Blocking ◽  
Dopamine D2 ◽  
Receptor Dimers

scholarly journals PARANOID SCHIZOPHRENIA -BETWEEN HYPERSEXUALITY AND SADOMASOCHISM

2021 ◽  
Vol 9 (3) ◽  
pp. 195-203
Author(s):  
Simona Trifu ◽  
Beligeanu Mihaela ◽  
Iacob Beatrice Ștefana ◽  
Larimian Ștefania Parisa
Keyword(s):  
Personality Disorder ◽  
Personality Disorders ◽  
Defense Mechanisms ◽  
Paranoid Schizophrenia ◽  
Point Of View ◽  
Obsessive Compulsive ◽  
Schizotypal Personality ◽  
Paternal Line ◽  
Axis I ◽  
Obsessive Compulsive Personality Disorder

Motivation/Background: In this paper we aimed at clinically analyzing a patient diagnosed with paranoid schizophrenia, who also displays features specific to multiple personality disorders, in the context of a presentation whose key topic is sexuality. Given the global prevalence and the severity of schizophrenia, it is increasingly important to appropriately adapt and identify the patients' clinical and non-clinical personality profile. This paper also aims at making the profile of a patient diagnosed with axis I disorder ever since the age of 19, who also has got traits specific to certain personality disorders. At the same time, the work provides an interpretation of the behaviour from the psycho-dynamic point of view. Method: The following instruments were used for performing the analysis: a clinical interview, heteroanamnesis, psychological tests, clinical course monitoring, psychodynamic interpretations, defence mechanisms identification, psychiatric observation and treatment. Results: Based on the materials aforementioned, it has been established a possible diagnosis which includes multiple disorders: Antisocial Personality Disorder, Histrionic Personality Disorder, Schizotypal Personality Disorder, Obsessive Compulsive Personality Disorder, Cotard Syndrome, Kandinsky-Clérambault Syndrome. and there were identified defense mechanisms and coping strategies, under the influence of sexuality and sadomasochistic impulses. Conclusions: It is highlighted the clinical picture of a patient with paranoid schizophrenia, who presents symptoms for differential diagnoses, with disorganized discourse focused on sexuality, with delusional ideation, psychotic manifestation, but also with high suggestibility, especially on the paternal line

scholarly journals Clonazepam improves dopamine supersensitivity in a schizophrenia patient: a case report

2016 ◽  
Vol 7 (3) ◽  
pp. 113-117 ◽  
Author(s):  
Mina Fukai ◽  
Tetsu Hirosawa ◽  
Tetsuya Takahashi ◽  
Reizo Kaneda ◽  
Mitsuru Kikuchi ◽  
...  
Keyword(s):  
Schizophrenia Patient ◽  
Clinical Symptoms ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Psychotic Symptoms ◽  
Treatment Resistant ◽  
Effective Option ◽  
History Of ◽  
Dopamine Supersensitivity ◽  
Malignant Catatonia

Dopamine supersensitivity is an important consideration for assessing treatment-resistant schizophrenia. The emergence of dopamine supersensitivity might be related to upregulation of dopamine D2 receptor, which engenders tolerance to antipsychotics, rebound psychosis, and tardive dyskinesia (TD). A 24-year-old man with a history of treatment-resistant schizophrenia was hospitalized for treatment of bone fracture sustained during a suicide attempt. After the operation, his clinical symptoms implied malignant catatonia. The patient discontinued antipsychotics without rebound psychosis under clonazepam treatment. His psychotic symptoms were controlled further with 24 mg/day aripiprazole without relapse or worsening. Clonazepam might be an effective option for the management of dopamine supersensitivity psychosis (DSP).

scholarly journals Repeated aripiprazole treatment causes dopamine D2 receptor up-regulation and dopamine supersensitivity in young rats

2013 ◽  
Vol 28 (4) ◽  
pp. 376-386 ◽  
Author(s):  
Fausto A Varela ◽  
Taleen Der-Ghazarian ◽  
Ryan J Lee ◽  
Sergios Charntikov ◽  
Cynthia A Crawford ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Young Rats ◽  
Dopamine D2 ◽  
Dopamine Supersensitivity

scholarly journals Nardosinone Alleviates Parkinson’s Disease Symptoms in Mice by Regulating Dopamine D2 Receptor

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Li-hua Bian ◽  
Zi-wei Yao ◽  
Cheng-bowen Zhao ◽  
Qiu-yu Li ◽  
Jin-li Shi ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Interaction Network ◽  
Network Pharmacology ◽  
Cognitive Symptoms ◽  
Behavioral Tests ◽  
Disease Symptoms ◽  
Nardostachys Jatamansi ◽  
The Brain ◽  
Orbitrap Ms

Nardostachyos Radix et Rhizoma (nardostachys) is the root and rhizome of Nardostachys jatamansi DC. Recent studies have shown that nardostachys may exert an anti-PD effect. In this study, the UHPLC-LTQ-Orbitrap-MS method was used to analyze the brain components of nardostachys in rats. Based on the results of UHPLC-LTQ-Orbitrap-MS analysis, nardosinone was identified to be the most effective anti-PD compound in nardostachys. To further verify this inference, a mouse PD model was established and the effect of nardosinone on PD mice was determined using classic behavioral tests. The results showed that nardosinone was indeed effective for relieving PD symptoms in mice. Moreover, network pharmacology analysis was used to elucidate the mechanism underlying the anti-PD effect of nardosinone. Dopamine receptor D2 (DRD2) was identified as the key target of nardosinone-PD interaction network, which was further verified by molecular docking and Western blotting. The results demonstrated that nardosinone and DRD2 could interact with each other. Furthermore, the expression level of DRD2 was decreased in the brain tissue of PD mice, and nardosinone could restore its expression to a certain extent. In conclusion, our findings suggest that nardosinone may reduce the motor and cognitive symptoms in the animal PD model by regulating DRD2 expression.

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