scholarly journals The Role of the Leucocytosis Parameter in the Occurrence of Pregnancy Complications in Women with Periodontal Disease

2019 ◽  
Vol 70 (11) ◽  
pp. 3967-3970
Keyword(s):  
Periodontal Disease ◽  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Second Trimester ◽  
Intrauterine Growth ◽  
Obstetrics And Gynaecology ◽  
Severe Periodontitis ◽  
Significant Difference ◽  
Control Segment

For the present study, a total number of 109 pregnant patients in the second trimester of pregnancy were selected from the case studies of the Clinic of Obstetrics and Gynaecology of the Municipal Clinical Hospital Filantropia in Craiova. Among these, 56 patients had gingivitis, 26 had mild, moderate, or severe periodontitis, and 27 patients were used as a control segment. Each patient had her leukocytes values tested and they had their oral cavity examined. Leukocyte neutrophils are the primary cells of the body’s defence system as well as primary protective cells against periodontal disease. Based on the study, we can say that there is a significant difference between the average number of leukocytes found in the four groups, because the result of the ANOVA test was below the threshold p <0.001. By analyzing the involvement of the leucocytosis parameter in the occurrence or presence of pregnancy complications, we found it present in periodontal disease pregnant women who had complications, namely: premature birth, preeclampsia, or intrauterine growth restriction. Keywords: periodontitis, leukocytes, pregnant, preterm birth

scholarly journals The Role of the Leucocytosis Parameter in the Occurrence of Pregnancy Complications in Women with Periodontal Disease

2019 ◽  
Vol 70 (11) ◽  
pp. 3967-3970
Author(s):  
Camelia Fiera Maglaviceanu ◽  
Edwin Sever Bechir ◽  
Mihaela Jana Tuculina ◽  
Constantin Daguci ◽  
Ionela Teodora Dascalu ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
The Body ◽  
Intrauterine Growth ◽  
Obstetrics And Gynaecology ◽  
Severe Periodontitis ◽  
Significant Difference ◽  
Control Segment

For the present study, a total number of 109 pregnant patients in the second trimester of pregnancy were selected from the case studies of the Clinic of Obstetrics and Gynaecology of the Municipal Clinical Hospital Filantropia in Craiova. Among these, 56 patients had gingivitis, 26 had mild, moderate, or severe periodontitis, and 27 patients were used as a control segment. Each patient had her leukocytes values tested and they had their oral cavity examined. Leukocyte neutrophils are the primary cells of the body�s defence system as well as primary protective cells against periodontal disease. Based on the study, we can say that there is a significant difference between the average number of leukocytes found in the four groups, because the result of the ANOVA test was below the threshold p [0.001. By analyzing the involvement of the leucocytosis parameter in the occurrence or presence of pregnancy complications, we found it present in periodontal disease pregnant women who had complications, namely: premature birth, preeclampsia, or intrauterine growth restriction.

scholarly journals Assessing the Outcome of Management of Thyroid Dysfunction in Pregnancy With Second Affiliated Hospital of Chongqing Medical University Guideline.

2021 ◽  
Author(s):  
Samuel Chigbo Obiegbusi ◽  
Xiao Jing Dong ◽  
Ming yu Deng ◽  
Chidera Nneji Obiegbusi ◽  
Yin Yang ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Thyroid Disease ◽  
Intrauterine Growth Restriction ◽  
Thyroid Dysfunction ◽  
Second Trimester ◽  
Intrauterine Growth ◽  
Chinese Medical Association ◽  
Significant Difference ◽  
Medical University ◽  
In Pregnancy

Abstract Introduction – Pregnancy comes with hormonal changes which, when not properly managed, could lead to complications. Thyroid hormone is one of the hormones that are affected during pregnancy, and it plays a significant role in pregnancy, from conception to delivery. In a bid to identify intended pregnant women and pregnant women with thyroid dysfunction, the Endocrinology Branch of Chinese Medical Association and Perinatal medicine branch of Chinese Medical Association set guidelines for diagnosis and treatment of thyroid diseases in pregnancy and postpartum women. The guideline recommends screening for all women who desire getting pregnant soon and pregnant women, which Second Affiliated Hospital of Chongqing Medical University is implementing.Purpose - To Identify the common thyroid disease found among pregnant women in Chongqing. Evaluate the effectiveness of the management guideline toward improving pregnancy outcome among women diagnosed with thyroid disease during their pregestational and gestational period, and ascertain the need for additional measures to be taken towards thyroid disease management during pregnancy in certain areas with unfavourable outcome.Method – A retrospective cohort study of 774 pregnant women diagnosed with thyroid dysfunction in the Second Affiliated Hospital of Chongqing Medical University from 2016 -2018 was extracted from the hospital computer patient’s record. Only 724 patients that met the inclusive criteria were analysed. Participants were grouped into four, according to the time they were diagnosed and managed. The Multiple logistic regression and binary logistic regression statistical analysis were done with SPSS, and we adjusted for potential confounders, including maternal age, parity, and gravida.Result – There is an association between maternal age and abortion among pregnant women diagnosed with subclinical hypothyroidism, P-0.018(OR 1.459, 95%CI 1.067-1.997) and significant difference in pregnant women who developed intrauterine growth restriction after being diagnosed with hypothyroidism in the second trimester, P-0.048(OR-0.152, 95%CI 0.024-0.981). There was also a significant difference in gravida, P-0.032(OR 1.368, 95%CI 1.028 1.821) and normal delivery mode, P-0.010(OR 2.521, 95%CI 1.246-5.100).Conclusion – The study shows a promising result as less complication is observed. However, more attention is needed toward managing subclinical hypothyroidism in pregnancy to curb abortion/miscarriage incidence. Hypothyroidism in second trimester could lead to intrauterine growth restriction. Multigravida increases the risk of complication among pregnant women with thyroid dysfunction.

scholarly journals The risk of cesarean delivery after labor induction among women with prior pregnancy complications: A subgroup analysis of the AFFIRM study

2019 ◽  
Author(s):  
Leslie Skeith ◽  
Grégoire Le Gal ◽  
Johanna IP de Vries ◽  
Saskia Middeldorp ◽  
Mariëtte Goddijn ◽  
...  
Keyword(s):  
Cesarean Delivery ◽  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Primary Outcome ◽  
Late Pregnancy ◽  
Labor Induction ◽  
Intrauterine Growth ◽  
Randomized Controlled ◽  
Level Data

Abstract Objective: To determine the risk of cesarean delivery after labor induction among patients with prior placenta-mediated pregnancy complications (pre-eclampsia, late pregnancy loss, placental abruption or intrauterine growth restriction). Study Design: The AFFIRM database includes patient level data from 9 randomized controlled trials that evaluated the role of LMWH versus no LMWH during pregnancy to prevent recurrent placenta-mediated pregnancy complications. The primary outcome of this sub-study was the proportion of women who had an unplanned cesarean delivery after induction of labor compared to after spontaneous labor. Results: There were 512 patients from 7 randomized trials included in our sub-study. There was no difference in the risk of cesarean delivery between women with labor induction (21/148, 14.2%) and spontaneous labor (79/364, 21.7%) (odds ratio (OR) 0.60, 95% CI, 0.35-1.01; p=0.052). Among 274 women who used LMWH prophylaxis during pregnancy, the risk of cesarean delivery was lower among those that underwent labor induction (9.8%) compared to spontaneous labor (22.4%) (OR 0.38, 95% CI, 0.17-0.84; p=0.01). Conclusions: The risk of cesarean delivery is not increased after labor induction among a higher risk patient population with prior pregnancy complications. Our results suggest that women who receive LMWH during pregnancy might benefit from labor induction.

Thrombophilia and pregnancy complications

2004 ◽  
Vol 92 (10) ◽  
pp. 678-681 ◽  
Author(s):  
Eric Grabowski ◽  
Margaretta Hellgren ◽  
Gili Kenet ◽  
Patricia Massicotte ◽  
Marilyn Manco-Johnson ◽  
...  
Keyword(s):  
International Society ◽  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Fetal Loss ◽  
Vascular Complications ◽  
First Trimester ◽  
Second Trimester ◽  
Health Issues ◽  
Intrauterine Growth ◽  
Consensus Report

SummaryThe implications of currently available data on the association of gestational vascular complications with thrombophilia are presented in this consensus report. Screening is recommended for women with the following previous complications: fetal loss including three or more first trimester loss, two or more second trimester loss, or any stillbirth; early, severe or recurrent preeclampsia and severe intrauterine growth restriction. Maternal antithrombotic therapy is currently evaluated in women with thrombophilia and previous complications.On behalf of the Scientific Subcommittee on Perinatal and Pediatric Hemostasis and Working Group on Women’s health Issues and Standardization Committee of the International Society of Thrombosis and Hemostasis.

scholarly journals The risk of cesarean delivery after labor induction among women with prior pregnancy complications: a subgroup analysis of the AFFIRM study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Leslie Skeith ◽  
◽  
Grégoire Le Gal ◽  
Johanna I. P. de Vries ◽  
Saskia Middeldorp ◽  
...  
Keyword(s):  
Cesarean Delivery ◽  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Primary Outcome ◽  
Late Pregnancy ◽  
Labor Induction ◽  
Intrauterine Growth ◽  
Randomized Controlled ◽  
Level Data

Abstract Background To determine the risk of cesarean delivery after labor induction among patients with prior placenta-mediated pregnancy complications (pre-eclampsia, late pregnancy loss, placental abruption or intrauterine growth restriction). Methods The AFFIRM database includes patient level data from 9 randomized controlled trials that evaluated the role of LMWH versus no LMWH during pregnancy to prevent recurrent placenta-mediated pregnancy complications. The primary outcome of this sub-study was the proportion of women who had an unplanned cesarean delivery after induction of labor compared to after spontaneous labor. Results There were 512 patients from 7 randomized trials included in our sub-study. There was no difference in the risk of cesarean delivery between women with labor induction (21/148, 14.2%) and spontaneous labor (79/364, 21.7%) (odds ratio (OR) 0.60, 95% CI, 0.35–1.01; p = 0.052). Among 274 women who used LMWH prophylaxis during pregnancy, the risk of cesarean delivery was lower among those that underwent labor induction (9.8%) compared to spontaneous labor (22.4%) (OR 0.38, 95% CI, 0.17–0.84; p = 0.01). Conclusions The risk of cesarean delivery is not increased after labor induction among a higher risk patient population with prior pregnancy complications. Our results suggest that women who receive LMWH during pregnancy might benefit from labor induction.

scholarly journals The physiologic and therapeutic role of Heparin in implantation and placentation

2014 ◽  
Author(s):  
Michela Quaranta ◽  
Offer Erez ◽  
Salvatore Andrea Mastrolia ◽  
Arie Koifman ◽  
Elad Leron ◽  
...  
Keyword(s):  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Preterm Labor ◽  
Normal Pregnancy ◽  
Fetal Demise ◽  
Therapeutic Role ◽  
Intrauterine Growth ◽  
Treatment And Prevention ◽  
Normal Gestation

Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications named the great obstetrical syndromes (preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture or membranes, preterm labor, and recurrent pregnancy loss). There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review we will summarize the properties and the physiological contribute of heparins to the success of implantation and placentation and normal pregnancy.

scholarly journals The role of Sirtuin1–PPARγ axis in placental development and function

2018 ◽  
Vol 60 (4) ◽  
pp. R201-R212 ◽  
Author(s):  
Jonathan Pham ◽  
Kanaga Arul Nambi Rajan ◽  
Ping Li ◽  
Mana M Parast
Keyword(s):  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Multiple Pregnancy ◽  
Well Being ◽  
Sirtuin 1 ◽  
Hypertensive Disorder ◽  
Placental Development ◽  
Intrauterine Growth ◽  
And Function

Placental development is important for proper in utero growth and development of the fetus, as well as maternal well-being during pregnancy. Abnormal differentiation of placental epithelial cells, called trophoblast, is at the root of multiple pregnancy complications, including miscarriage, the maternal hypertensive disorder preeclampsia and intrauterine growth restriction. The ligand-activated nuclear receptor, PPARγ, and nutrient sensor, Sirtuin-1, both play a role in numerous pathways important to cell survival and differentiation, metabolism and inflammation. However, each has also been identified as a key player in trophoblast differentiation and placental development. This review details these studies, and also describes how various stressors, including hypoxia and inflammation, alter the expression or activity of PPARγ and Sirtuin-1, thereby contributing to placenta-based pregnancy complications.

scholarly journals The risk of cesarean delivery after labor induction among women with prior pregnancy complications: A subgroup analysis of the AFFIRM study

2019 ◽  
Author(s):  
Leslie Skeith ◽  
Grégoire Le Gal ◽  
Johanna IP de Vries ◽  
Saskia Middeldorp ◽  
Mariëtte Goddijn ◽  
...  
Keyword(s):  
Cesarean Delivery ◽  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Primary Outcome ◽  
Late Pregnancy ◽  
Labor Induction ◽  
Intrauterine Growth ◽  
Randomized Controlled ◽  
Level Data

Abstract Objective: To determine the risk of cesarean delivery after labor induction among patients with prior placenta-mediated pregnancy complications (pre-eclampsia, late pregnancy loss, placental abruption or intrauterine growth restriction). Study Design: The AFFIRM database includes patient level data from 9 randomized controlled trials that evaluated the role of LMWH versus no LMWH during pregnancy to prevent recurrent placenta-mediated pregnancy complications. The primary outcome of this sub-study was the proportion of women who had an unplanned cesarean delivery after induction of labor compared to after spontaneous labor. Results: There were 512 patients from 7 randomized trials included in our sub-study. There was no difference in the risk of cesarean delivery between women with labor induction (21/148, 14.2%) and spontaneous labor (79/364, 21.7%) (odds ratio (OR) 0.60, 95% CI, 0.35-1.01; p=0.052). Among 274 women who used LMWH prophylaxis during pregnancy, the risk of cesarean delivery was lower among those that underwent labor induction (9.8%) compared to spontaneous labor (22.4%) (OR 0.38, 95% CI, 0.17-0.84; p=0.01). Conclusions: The risk of cesarean delivery is not increased after labor induction among a higher risk patient population with prior pregnancy complications. Our results suggest that women who receive LMWH during pregnancy might benefit from labor induction.

scholarly journals Assessing the outcome of management of thyroid dysfunction in pregnancy with second affiliated hospital of Chongqing Medical University guideline.

2021 ◽  
Author(s):  
Samuel Obiegbusi ◽  
Xiao Dong ◽  
Mingyu Deng ◽  
Chidera Obiegbusi ◽  
Yin Yang ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Thyroid Disease ◽  
Intrauterine Growth Restriction ◽  
Thyroid Dysfunction ◽  
Second Trimester ◽  
Intrauterine Growth ◽  
Chinese Medical Association ◽  
Significant Difference ◽  
Medical University ◽  
In Pregnancy

Abstract Pregnancy comes with hormonal changes which, when not properly managed, could lead to complications. Thyroid hormone is one of the hormones that are affected during pregnancy, and it plays a significant role in pregnancy, from conception to delivery. In a bid to identify intended pregnant women and pregnant women with thyroid dysfunction, the Endocrinology Branch of Chinese Medical Association and Perinatal medicine branch of Chinese Medical Association set guidelines for diagnosis and treatment of thyroid diseases in pregnancy and postpartum women. The guideline recommends screening for all women who desire getting pregnant soon and pregnant women, which Second Affiliated Hospital of Chongqing Medical University is implementing. This study was carried out to Identify the common thyroid disease found among pregnant women in Chongqing, evaluate the effectiveness of the management guideline toward improving pregnancy outcome among women diagnosed with thyroid disease during their pregestational and gestational period, and ascertain the need for additional measures to be taken towards thyroid disease management during pregnancy in certain areas with unfavourable outcome. Our findings showed an association between maternal age and abortion among pregnant women diagnosed with subclinical hypothyroidism, P-0.018(OR 1.459, 95%CI 1.067–1.997) and significant difference in pregnant women who developed intrauterine growth restriction after being diagnosed with hypothyroidism in the second trimester, P-0.048(OR-0.152, 95%CI 0.024–0.981). There was also a significant difference in gravida, P-0.032(OR 1.368, 95%CI 1.028 1.821) and normal delivery mode, P-0.010(OR 2.521, 95%CI 1.246-5.100). The study shows a promising result as less complication is observed. However, more attention is needed toward managing subclinical hypothyroidism in pregnancy to curb abortion/miscarriage incidence. Hypothyroidism in second trimester could lead to intrauterine growth restriction. Multigravida increases the risk of complication among pregnant women with thyroid dysfunction.

scholarly journals The risk of cesarean delivery after labor induction among women with prior pregnancy complications: A subgroup analysis of the AFFIRM study

2019 ◽  
Author(s):  
Leslie Skeith ◽  
Grégoire Le Gal ◽  
Johanna IP de Vries ◽  
Saskia Middeldorp ◽  
Mariëtte Goddijn ◽  
...  
Keyword(s):  
Cesarean Delivery ◽  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Primary Outcome ◽  
Late Pregnancy ◽  
Labor Induction ◽  
Intrauterine Growth ◽  
Randomized Controlled ◽  
Level Data

Abstract Objective: To determine the risk of cesarean delivery after labor induction among patients with prior placenta-mediated pregnancy complications (pre-eclampsia, late pregnancy loss, placental abruption or intrauterine growth restriction). Study Design: The AFFIRM database includes patient level data from 9 randomized controlled trials that evaluated the role of LMWH versus no LMWH during pregnancy to prevent recurrent placenta-mediated pregnancy complications. The primary outcome of this sub-study was the proportion of women who had an unplanned cesarean delivery after induction of labor compared to after spontaneous labor. Results: There were 512 patients from 7 randomized trials included in our sub-study. There was no difference in the risk of cesarean delivery between women with labor induction (21/148, 14.2%) and spontaneous labor (79/364, 21.7%) (odds ratio (OR) 0.60, 95% CI, 0.35-1.01; p=0.052). Among 274 women who used LMWH prophylaxis during pregnancy, the risk of cesarean delivery was lower among those that underwent labor induction (9.8%) compared to spontaneous labor (22.4%) (OR 0.38, 95% CI, 0.17-0.84; p=0.01). Conclusions: The risk of cesarean delivery is not increased after labor induction among a higher risk patient population with prior pregnancy complications. Our results suggest that women who receive LMWH during pregnancy might benefit from labor induction.

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