The Role of the Leucocytosis Parameter in the Occurrence of Pregnancy Complications in Women with Periodontal Disease

For the present study, a total number of 109 pregnant patients in the second trimester of pregnancy were selected from the case studies of the Clinic of Obstetrics and Gynaecology of the Municipal Clinical Hospital Filantropia in Craiova. Among these, 56 patients had gingivitis, 26 had mild, moderate, or severe periodontitis, and 27 patients were used as a control segment. Each patient had her leukocytes values tested and they had their oral cavity examined. Leukocyte neutrophils are the primary cells of the body’s defence system as well as primary protective cells against periodontal disease. Based on the study, we can say that there is a significant difference between the average number of leukocytes found in the four groups, because the result of the ANOVA test was below the threshold p <0.001. By analyzing the involvement of the leucocytosis parameter in the occurrence or presence of pregnancy complications, we found it present in periodontal disease pregnant women who had complications, namely: premature birth, preeclampsia, or intrauterine growth restriction. Keywords: periodontitis, leukocytes, pregnant, preterm birth

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The risk of cesarean delivery after labor induction among women with prior pregnancy complications: A subgroup analysis of the AFFIRM study

10.21203/rs.2.11596/v3 ◽

2019 ◽

Author(s):

Leslie Skeith ◽

Grégoire Le Gal ◽

Johanna IP de Vries ◽

Saskia Middeldorp ◽

Mariëtte Goddijn ◽

...

Keyword(s):

Cesarean Delivery ◽

Pregnancy Complications ◽

Intrauterine Growth Restriction ◽

Primary Outcome ◽

Late Pregnancy ◽

Labor Induction ◽

Intrauterine Growth ◽

Randomized Controlled ◽

Level Data

Abstract Objective: To determine the risk of cesarean delivery after labor induction among patients with prior placenta-mediated pregnancy complications (pre-eclampsia, late pregnancy loss, placental abruption or intrauterine growth restriction). Study Design: The AFFIRM database includes patient level data from 9 randomized controlled trials that evaluated the role of LMWH versus no LMWH during pregnancy to prevent recurrent placenta-mediated pregnancy complications. The primary outcome of this sub-study was the proportion of women who had an unplanned cesarean delivery after induction of labor compared to after spontaneous labor. Results: There were 512 patients from 7 randomized trials included in our sub-study. There was no difference in the risk of cesarean delivery between women with labor induction (21/148, 14.2%) and spontaneous labor (79/364, 21.7%) (odds ratio (OR) 0.60, 95% CI, 0.35-1.01; p=0.052). Among 274 women who used LMWH prophylaxis during pregnancy, the risk of cesarean delivery was lower among those that underwent labor induction (9.8%) compared to spontaneous labor (22.4%) (OR 0.38, 95% CI, 0.17-0.84; p=0.01). Conclusions: The risk of cesarean delivery is not increased after labor induction among a higher risk patient population with prior pregnancy complications. Our results suggest that women who receive LMWH during pregnancy might benefit from labor induction.

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The risk of cesarean delivery after labor induction among women with prior pregnancy complications: a subgroup analysis of the AFFIRM study

BMC Pregnancy and Childbirth ◽

10.1186/s12884-019-2615-x ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Leslie Skeith ◽

◽

Grégoire Le Gal ◽

Johanna I. P. de Vries ◽

Saskia Middeldorp ◽

...

Keyword(s):

Cesarean Delivery ◽

Pregnancy Complications ◽

Intrauterine Growth Restriction ◽

Primary Outcome ◽

Late Pregnancy ◽

Labor Induction ◽

Intrauterine Growth ◽

Randomized Controlled ◽

Level Data

Abstract Background To determine the risk of cesarean delivery after labor induction among patients with prior placenta-mediated pregnancy complications (pre-eclampsia, late pregnancy loss, placental abruption or intrauterine growth restriction). Methods The AFFIRM database includes patient level data from 9 randomized controlled trials that evaluated the role of LMWH versus no LMWH during pregnancy to prevent recurrent placenta-mediated pregnancy complications. The primary outcome of this sub-study was the proportion of women who had an unplanned cesarean delivery after induction of labor compared to after spontaneous labor. Results There were 512 patients from 7 randomized trials included in our sub-study. There was no difference in the risk of cesarean delivery between women with labor induction (21/148, 14.2%) and spontaneous labor (79/364, 21.7%) (odds ratio (OR) 0.60, 95% CI, 0.35–1.01; p = 0.052). Among 274 women who used LMWH prophylaxis during pregnancy, the risk of cesarean delivery was lower among those that underwent labor induction (9.8%) compared to spontaneous labor (22.4%) (OR 0.38, 95% CI, 0.17–0.84; p = 0.01). Conclusions The risk of cesarean delivery is not increased after labor induction among a higher risk patient population with prior pregnancy complications. Our results suggest that women who receive LMWH during pregnancy might benefit from labor induction.

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The physiologic and therapeutic role of Heparin in implantation and placentation

10.7287/peerj.preprints.486 ◽

2014 ◽

Author(s):

Michela Quaranta ◽

Offer Erez ◽

Salvatore Andrea Mastrolia ◽

Arie Koifman ◽

Elad Leron ◽

...

Keyword(s):

Pregnancy Complications ◽

Intrauterine Growth Restriction ◽

Preterm Labor ◽

Normal Pregnancy ◽

Fetal Demise ◽

Therapeutic Role ◽

Intrauterine Growth ◽

Treatment And Prevention ◽

Normal Gestation

Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications named the great obstetrical syndromes (preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture or membranes, preterm labor, and recurrent pregnancy loss). There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review we will summarize the properties and the physiological contribute of heparins to the success of implantation and placentation and normal pregnancy.

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The role of Sirtuin1–PPARγ axis in placental development and function

Journal of Molecular Endocrinology ◽

10.1530/jme-17-0315 ◽

2018 ◽

Vol 60 (4) ◽

pp. R201-R212 ◽

Cited By ~ 8

Author(s):

Jonathan Pham ◽

Kanaga Arul Nambi Rajan ◽

Ping Li ◽

Mana M Parast

Keyword(s):

Pregnancy Complications ◽

Intrauterine Growth Restriction ◽

Multiple Pregnancy ◽

Well Being ◽

Sirtuin 1 ◽

Hypertensive Disorder ◽

Placental Development ◽

Intrauterine Growth ◽

And Function

Placental development is important for proper in utero growth and development of the fetus, as well as maternal well-being during pregnancy. Abnormal differentiation of placental epithelial cells, called trophoblast, is at the root of multiple pregnancy complications, including miscarriage, the maternal hypertensive disorder preeclampsia and intrauterine growth restriction. The ligand-activated nuclear receptor, PPARγ, and nutrient sensor, Sirtuin-1, both play a role in numerous pathways important to cell survival and differentiation, metabolism and inflammation. However, each has also been identified as a key player in trophoblast differentiation and placental development. This review details these studies, and also describes how various stressors, including hypoxia and inflammation, alter the expression or activity of PPARγ and Sirtuin-1, thereby contributing to placenta-based pregnancy complications.

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The risk of cesarean delivery after labor induction among women with prior pregnancy complications: A subgroup analysis of the AFFIRM study

10.21203/rs.2.11596/v1 ◽

2019 ◽

Author(s):

Leslie Skeith ◽

Grégoire Le Gal ◽

Johanna IP de Vries ◽

Saskia Middeldorp ◽

Mariëtte Goddijn ◽

...

Keyword(s):

Cesarean Delivery ◽

Pregnancy Complications ◽

Intrauterine Growth Restriction ◽

Primary Outcome ◽

Late Pregnancy ◽

Labor Induction ◽

Intrauterine Growth ◽

Randomized Controlled ◽

Level Data

Abstract Objective: To determine the risk of cesarean delivery after labor induction among patients with prior placenta-mediated pregnancy complications (pre-eclampsia, late pregnancy loss, placental abruption or intrauterine growth restriction). Study Design: The AFFIRM database includes patient level data from 9 randomized controlled trials that evaluated the role of LMWH versus no LMWH during pregnancy to prevent recurrent placenta-mediated pregnancy complications. The primary outcome of this sub-study was the proportion of women who had an unplanned cesarean delivery after induction of labor compared to after spontaneous labor. Results: There were 512 patients from 7 randomized trials included in our sub-study. There was no difference in the risk of cesarean delivery between women with labor induction (21/148, 14.2%) and spontaneous labor (79/364, 21.7%) (odds ratio (OR) 0.60, 95% CI, 0.35-1.01; p=0.052). Among 274 women who used LMWH prophylaxis during pregnancy, the risk of cesarean delivery was lower among those that underwent labor induction (9.8%) compared to spontaneous labor (22.4%) (OR 0.38, 95% CI, 0.17-0.84; p=0.01). Conclusions: The risk of cesarean delivery is not increased after labor induction among a higher risk patient population with prior pregnancy complications. Our results suggest that women who receive LMWH during pregnancy might benefit from labor induction.

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The risk of cesarean delivery after labor induction among women with prior pregnancy complications: A subgroup analysis of the AFFIRM study

10.21203/rs.2.11596/v2 ◽

2019 ◽

Author(s):

Leslie Skeith ◽

Grégoire Le Gal ◽

Johanna IP de Vries ◽

Saskia Middeldorp ◽

Mariëtte Goddijn ◽

...

Keyword(s):

Cesarean Delivery ◽

Pregnancy Complications ◽

Intrauterine Growth Restriction ◽

Primary Outcome ◽

Late Pregnancy ◽

Labor Induction ◽

Intrauterine Growth ◽

Randomized Controlled ◽

Level Data

Abstract Objective: To determine the risk of cesarean delivery after labor induction among patients with prior placenta-mediated pregnancy complications (pre-eclampsia, late pregnancy loss, placental abruption or intrauterine growth restriction). Study Design: The AFFIRM database includes patient level data from 9 randomized controlled trials that evaluated the role of LMWH versus no LMWH during pregnancy to prevent recurrent placenta-mediated pregnancy complications. The primary outcome of this sub-study was the proportion of women who had an unplanned cesarean delivery after induction of labor compared to after spontaneous labor. Results: There were 512 patients from 7 randomized trials included in our sub-study. There was no difference in the risk of cesarean delivery between women with labor induction (21/148, 14.2%) and spontaneous labor (79/364, 21.7%) (odds ratio (OR) 0.60, 95% CI, 0.35-1.01; p=0.052). Among 274 women who used LMWH prophylaxis during pregnancy, the risk of cesarean delivery was lower among those that underwent labor induction (9.8%) compared to spontaneous labor (22.4%) (OR 0.38, 95% CI, 0.17-0.84; p=0.01). Conclusions: The risk of cesarean delivery is not increased after labor induction among a higher risk patient population with prior pregnancy complications. Our results suggest that women who receive LMWH during pregnancy might benefit from labor induction.

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The physiologic and therapeutic role of Heparin in implantation and placentation

10.7287/peerj.preprints.486v1 ◽

2014 ◽

Author(s):

Michela Quaranta ◽

Offer Erez ◽

Salvatore Andrea Mastrolia ◽

Arie Koifman ◽

Elad Leron ◽

...

Keyword(s):

Pregnancy Complications ◽

Intrauterine Growth Restriction ◽

Preterm Labor ◽

Normal Pregnancy ◽

Fetal Demise ◽

Therapeutic Role ◽

Intrauterine Growth ◽

Treatment And Prevention ◽

Normal Gestation

Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications named the great obstetrical syndromes (preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture or membranes, preterm labor, and recurrent pregnancy loss). There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review we will summarize the properties and the physiological contribute of heparins to the success of implantation and placentation and normal pregnancy.

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Effectiveness Of Toilet Training Education On Mother's Behavior And Toddler Age Toilet Training Ability (18-36 Months)

Jurnal Kesehatan Komunitas ◽

10.25311/keskom.vol5.iss2.288 ◽

2020 ◽

Vol 5 (2) ◽

pp. 49-55

Author(s):

Hafiko Andresni ◽

Zahtamal Zahtamal ◽

Winda Septiani ◽

Mitra Mitra ◽

Lita Lita

Keyword(s):

Sampling Technique ◽

T Test ◽

The Body ◽

Toilet Training ◽

Wilcoxon Test ◽

Control Group ◽

Maternal Knowledge ◽

Control Group Design ◽

Significant Difference

ABSTRACT Toilet training is an effort to train children to be able to control and urinate (BAK) and defecate (BAB). Toilet training is one of the main tasks of children at toddler age. Toilet training is one of the main tasks of children in toddler age which is very important to be done to create independence in children in controlling BAK and BAB and children know the parts of the body and their functions. Data in 2012 shows that ± 60% of parents do not teach toilet training to children from an early age. The aim of the study was to find out the effectiveness of toilet training education on maternal behavior and toilet skills in toddler age training (18-36 months). The study was conducted in July-August 2018. This type of quantitative research used the design of the Quasy pretest and posttest experiment with non-equivalent control group design. Samples were 36 mothers and 36 children with purposive sampling technique. Data analysis used Paired t test, Wilcoxon test, Man-Whitney test an Independent t test. The results showed that toilet training education through lecture methods, modules and maze games was more effective than toilet training education through lecture and leaflet methods on children's knowledge and abilities. Conversely, for the role of mothers in supervision there is no significant difference in effectiveness. Health education is recommended in health promotion programs to increase maternal knowledge, the role of mothers and the ability of toilet training children independently. Keywords: Toilet training, Lecture method, Module, Maze game, Leaflet, Knowledge, Role of mother, Children's ability.

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Hypoxia and Mitochondrial Dysfunction in Pregnancy Complications

Antioxidants ◽

10.3390/antiox10030405 ◽

2021 ◽

Vol 10 (3) ◽

pp. 405 ◽

Cited By ~ 1

Author(s):

Xiang-Qun Hu ◽

Lubo Zhang

Keyword(s):

Pregnancy Complications ◽

Intrauterine Growth Restriction ◽

Animal Studies ◽

Major Effect ◽

Causative Role ◽

Therapeutic Approaches ◽

Maternal Complications ◽

Mitochondrial Ros ◽

Subsequent Risk

Hypoxia is a common and severe stress to an organism’s homeostatic mechanisms, and hypoxia during gestation is associated with significantly increased incidence of maternal complications of preeclampsia, adversely impacting on the fetal development and subsequent risk for cardiovascular and metabolic disease. Human and animal studies have revealed a causative role of increased uterine vascular resistance and placental hypoxia in preeclampsia and fetal/intrauterine growth restriction (FGR/IUGR) associated with gestational hypoxia. Gestational hypoxia has a major effect on mitochondria of uteroplacental cells to overproduce reactive oxygen species (ROS), leading to oxidative stress. Excess mitochondrial ROS in turn cause uteroplacental dysfunction by damaging cellular macromolecules, which underlies the pathogenesis of preeclampsia and FGR. In this article, we review the current understanding of hypoxia-induced mitochondrial ROS and their role in placental dysfunction and the pathogenesis of pregnancy complications. In addition, therapeutic approaches selectively targeting mitochondrial ROS in the placental cells are discussed.

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