Generalized Methodology Application for System Design

2022 ◽  
Vol 21 ◽  
pp. 10-17
Author(s):  
Alexander Zemliak

The design process for analogue circuit design is formulated on the basis of the optimum control theory. The artificially introduced special control vector is defined for the redistribution of computational costs between network analysis and parametric optimization. This redistribution minimizes computer time. The problem of the minimal-time network design can be formulated in this case as a classical problem of the optimal control for some functional minimization. There is a principal difference between the new approach and before elaborated methodology. This difference is based on a higher level of the problem generalization. In this case the structural basis of design strategies is more complete and this circumstance gives possibility to obtain a great value of computer time gain. Numerical results demonstrate the effectiveness and prospects of a more generalized approach to circuit optimization. This approach generalizes the design process and generates an infinite number of the different design strategies that will serve as the structural basis for the minimal time algorithm construction. This paper is advocated to electronic systems built with transistors. The main equations for the system design process were elaborated.

The design process for analog network design is formulated on the basis of the optimum control theory. The artificially introduced special control vector is defined for the redistribution of computational costs between network analysis and parametric optimization. This redistribution minimizes computer time. The problem of the minimal-time network design can be formulated in this case as a classical problem of the optimal control for some functional minimization. There is a principal difference between the new approach and before elaborated methodology. This difference is based on a higher level of the problem generalization. In this case the structural basis of design strategies is more complete and this circumstance gives possibility to obtain a great value of computer time gain. Numerical results demonstrate the effectiveness and prospects of a more generalized approach to circuit optimization.


Author(s):  
A. Zemliak ◽  
E. Rios ◽  
P. Miranda ◽  
K. Zemliak

The process of any analog system design has been formulated on the basis of the control theory application. This approach produces many different design strategies inside the same optimization procedure and allows determining the problem of the optimal design strategy existence from the computer time point of view. Different kinds of system design strategies have been evaluated from the operations number. The general methodology for the analog system design was formulated by means of the optimum control theory. The main equations for this design methodology were elaborated. These equations include the special control functions that are introduced artificially. This approach generalizes the design process and generates an infinite number of the different design strategies. The problem of the optimum design algorithm construction is defined as the minimum-time problem of the control theory. Numerical results of some electronic circuit design demonstrate the efficiency and perspective of the proposed methodology. These examples show that the computer time gain of the optimal design strategy with respect to the traditional design strategy increases when the size and complexity of the system increase. An additional acceleration effect of the design process has been discovered by the analysis of various design strategies with the different initial points. This effect is displayed for all analyzed circuits and it reduces additionally the total computer time for the system design.


2013 ◽  
Vol 1 (1) ◽  
pp. 158-178
Author(s):  
Urcun John Tanik

Cyberphysical system design automation utilizing knowledge based engineering techniques with globally networked knowledge bases can tremendously improve the design process for emerging systems. Our goal is to develop a comprehensive architectural framework to improve the design process for cyberphysical systems (CPS) and implement a case study with Axiomatic Design Solutions Inc. to develop next generation toolsets utilizing knowledge-based engineering (KBE) systems adapted to multiple domains in the field of CPS design automation. The Cyberphysical System Design Automation Framework (CPSDAF) will be based on advances in CPS design theory based on current research and knowledge collected from global sources automatically via Semantic Web Services. A case study utilizing STEM students is discussed.


2019 ◽  
Vol 25 (42) ◽  
pp. 5803-5821 ◽  
Author(s):  
Mona N. Rahman ◽  
Dragic Vukomanovic ◽  
Jason Z. Vlahakis ◽  
Walter A. Szarek ◽  
Kanji Nakatsu ◽  
...  

The development of isozyme-selective heme oxygenase (HO) inhibitors promises powerful pharmacological tools to elucidate the regulatory characteristics of the HO system. It is already known that HO has cytoprotective properties with a role in several disease states; thus, it is an enticing therapeutic target. Historically, the metalloporphyrins have been used as competitive HO inhibitors based on their structural similarity to the substrate, heme. However, heme’s important role in several other proteins (e.g. cytochromes P450, nitric oxide synthase), results in non-selectivity being an unfortunate side effect. Reports that azalanstat and other non-porphyrin molecules inhibited HO led to a multi-faceted effort over a decade ago to develop novel compounds as potent, selective inhibitors of HO. The result was the creation of the first generation of non-porphyrin based, non-competitive inhibitors with selectivity for HO, including a subset with isozyme selectivity for HO-1. Using X-ray crystallography, the structures of several complexes of HO-1 with novel inhibitors have been elucidated and provided insightful information regarding the salient features required for inhibitor binding. This included the structural basis for non-competitive inhibition, flexibility and adaptability of the inhibitor binding pocket, and multiple, potential interaction subsites, all of which can be exploited in future drug-design strategies. Notably, HO-1 inhibitors are of particular interest for the treatment of hyperbilirubinemia and certain types of cancer. Key features based on this initial study have already been used by others to discover additional potential HO-1 inhibitors. Moreover, studies have begun to use selected compounds and determine their effects in some disease models.


1972 ◽  
Vol 3 (1) ◽  
pp. 83-109 ◽  
Author(s):  
CHRISTOPHER E. NUGENT ◽  
THOMAS E. VOLLMANN
Keyword(s):  

2021 ◽  
Vol 13 (8) ◽  
pp. 4492
Author(s):  
Janka Saderova ◽  
Andrea Rosova ◽  
Marian Sofranko ◽  
Peter Kacmary

The warehouse process, as one of many logistics processes, currently holds an irreplaceable position in logistics systems in companies and in the supply chain. The proper function of warehouse operations depends on, among other things, the type of the used technology and their utilization. The research in this article is focused on the design of a warehouse system. The selection of a suitable warehouse system is a current research topic as the warehouse system has an impact on warehouse capacity and utilization and on the speed of storage activities. The paper presents warehouse system design methodology that was designed applying the logistics principle-systematic (system) approach. The starting point for designing a warehouse system represents of the process of design logistics systems. The design process consists of several phases: project identification, design process paradigm selection, system analysis, synthesis, and project evaluation. This article’s contribution is the proposed methodology and design of the warehouse system for the specified conditions. The methodology was implemented for the design of a warehouse system in a cold box, which is a part of a distribution warehouse. The technology of pallet racking was chosen in the warehouse to store pallets. Pallets will be stored and removed by forklifts. For the specified conditions, the warehouse system was designed for two alternatives of racking assemblies, which are served by forklifts. Alternative 1—Standard pallet rack with wide aisles and Alternative 2—Pallet dynamic flow rack. The proposed systems were compared on the basis of selected indicators: Capacity—the number of pallet places in the system, Percentage ratio of storage area from the box area, Percentage ratio of handling aisles from the box area, Access to individual pallets by forklift, Investment costs for 1 pallet space in EUR. Based on the multicriteria evaluation, the Alternative 2 was chosen as the acceptable design of the warehouse system with storage capacity 720 pallet units. The system needs only two handling aisles. Loading and unloading processes are separate from each other, which means that there are no collisions with forklifts. The pallets with the goods are operated on the principle of FIFO (first in, first out), which will facilitate the control of the shelf life of batches or series of products. The methodology is a suitable tool for decision-making in selecting and designing a warehouse system.


2013 ◽  
Vol 416-417 ◽  
pp. 1489-1494
Author(s):  
Long Cheng ◽  
Wei Ge ◽  
Bin Xue

As the main means of transport, Railcar performs main task of railway equipment repairing department. For managing railcar information better, upgrading the version of the DMI program version, basic data version, revealing data version of GYK on railcar, the paper develops railcar management system which is based on the B/S mode of J2EE lightweight development framework Struts-Spring-Hibernate (SSH) . This paper introduces the system design process and every function module in detail. Result proves that railcar management system improves the management efficiency of railcar, consists with the characteristics of the railcar and plays a positive role in the safety of railcar.


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