Anti-Osteoarthritis and Anti-Arthrodynia Effects of a Mixture of Fermented Achyranthes japonica Nakai, Angelica gigas Nakai, and Eucommia ulmoides Oliver Extracts on Monosodium Iodoacetate-Induced Arthritis in Rats

2019 ◽  
Vol 48 (11) ◽  
pp. 1179-1185 ◽  
Author(s):  
Dong-Hwan Choi ◽  
Sung-Jin Lee ◽  
Hyun Cheol Jeong ◽  
Kyung Min Kim ◽  
Min-Young Kwon ◽  
...  
Keyword(s):  
Eucommia Ulmoides ◽  
Angelica Gigas ◽  
Angelica Gigas Nakai ◽  
Eucommia Ulmoides Oliver ◽  
Achyranthes Japonica ◽  
Monosodium Iodoacetate

Anti-Proliferation Effects of Decursin from Angelica gigas Nakai in the MCF-7 Cells Treated with Environmental Hormones

2007 ◽  
Vol 36 (7) ◽  
pp. 825-831 ◽  
Author(s):  
Kyung-Wuk Park ◽  
Sa-Ra Choi ◽  
Hee-Sun Yang ◽  
Hyun-Wook Cho ◽  
Kap-Suk Kang ◽  
...  
Keyword(s):  
Angelica Gigas ◽  
Angelica Gigas Nakai ◽  
Mcf 7

scholarly journals Antithrombotic Effect of the Ethanol Extract of Angelica gigas Nakai (AGE 232)

Life ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 939
Author(s):  
Pia Loreto Werlinger Bravo ◽  
Hui Jin ◽  
Hyunwoo Park ◽  
Min Sang Kim ◽  
Hirofumi Matsui ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Thrombus Formation ◽  
Umbilical Vein ◽  
Ethanol Extract ◽  
Developed Countries ◽  
Severe Bleeding ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Angelica Gigas ◽  
Angelica Gigas Nakai

Cardiovascular diseases, such as stroke, are the most common causes of death in developed countries. Ischemic stroke accounts for 85% of the total cases and is caused by abnormal thrombus formation in the vessels, causing deficient blood and oxygen supply to the brain. Prophylactic treatments include the prevention of thrombus formation, of which the most used is acetylsalicylic acid (ASA); however, it is associated with a high incidence of side effects. Angelica gigas Nakai (AG) is a natural herb used to improve blood circulation via anti-platelet aggregation, one of the key processes involved in thrombus formation. We examined the antithrombotic effects of AGE 232, the ethanol extract of A. gigas Nakai. AGE 232 showed a significant reduction in death or paralysis in mice caused by collagen/epinephrine-induced thromboembolism in a dose-dependent manner and inhibition of collagen-induced human platelet aggregation in a concentration-dependent manner. Additionally, AGE 232-treated mice did not show severe bleeding in the gut compared to ASA-treated mice. AGE 232 resulted in a decrease in the number of neutrophils attached to the human umbilical vein endothelial cells (HUVECs) and lower inhibition of COX-1 in response to bleeding and damage to blood vessels, a major side effect of ASA. Therefore, AGE 232 can prevent thrombus formation and stroke.

Sign in / Sign up

Export Citation Format

Share Document