Endogenous hyperthermia in normal human subjects: I. Experimental study of evoked potentials and reaction time

Evidence is presented that the phylogenetically older retin-otectal pathway contributes to reflex orienting of visual attention in normal human subjects. The study exploited a lateralized neuroanatomic arrangement of retinotectal pathways that distinguishes them from those of the geniculostriate system; namely, more direct projections to the colliculus from the temporal hemifield. Subjects were tested under monocular viewing conditions and responded to the detection of a peripheral signal by making either a saccade to it or a choice reaction time manual keypress. Attention was summoned by noninformative peripheral precues, and the benefits and costs of attention were calculated relative to a central precue condition. Both the benefits and costs of orienting attention were greater when attention was summoned by signals in the temporal hemifield. This temporal hemifield advantage was present for both saccade and manual responses. These findings converge with observations in patients with occipital and midbrain lesions to show that the phylogenetically older retinotectal pathway retains an important role in controlling visually guided behavior; and they demonstrate the usefulness of temporal-nasal hemifield asymmetries as a marker for investigating extrageniculate vision in humans.

Download Full-text

Developmental changes of brainstem auditory evoked potentials (BAEPs) in normal human subjects from infants to young adults

Brain and Development ◽

10.1016/s0387-7604(82)80006-5 ◽

1982 ◽

Vol 4 (2) ◽

pp. 127-136 ◽

Cited By ~ 41

Author(s):

Yasuhiro Mochizuki ◽

Tohshin Go ◽

Hideo Ohkubo ◽

Takako Tatara ◽

Teruyuki Motomura

Keyword(s):

Young Adults ◽

Evoked Potentials ◽

Auditory Evoked Potentials ◽

Human Subjects ◽

Developmental Changes ◽

Brainstem Auditory Evoked Potentials ◽

Normal Human

Download Full-text

Motion reversal of visual evoked potentials in normal human subjects

Electroencephalography and Clinical Neurophysiology ◽

10.1016/0013-4694(95)92425-y ◽

1995 ◽

Vol 95 (5) ◽

pp. P112

Author(s):

W. Spileers ◽

E. Mangelschots ◽

H. Maes ◽

G.A. Orban

Keyword(s):

Evoked Potentials ◽

Visual Evoked Potentials ◽

Human Subjects ◽

Normal Human ◽

Visual Evoked ◽

Motion Reversal

Download Full-text

Effect of Different High-Pass Filters on the Long-Latency Event-Related Auditory Evoked Potentials in Normal Human Subjects and Individuals Infected with the Human Immunodeficiency Virus

Journal of Clinical Neurophysiology ◽

10.1097/00004691-199201000-00011 ◽

1992 ◽

Vol 9 (1) ◽

pp. 97-104 ◽

Cited By ~ 28

Author(s):

Douglas S. Goodin ◽

Michael J. Aminoff ◽

Rosemary S. Chequer

Keyword(s):

Human Immunodeficiency Virus ◽

Evoked Potentials ◽

Auditory Evoked Potentials ◽

Human Subjects ◽

Long Latency ◽

Immunodeficiency Virus ◽

Normal Human ◽

High Pass

Download Full-text

Observations on a Relationship between Steroid Metabolism and the Concentration of Plasma Fibrinogen

Thrombosis and Haemostasis ◽

10.1055/s-0038-1654793 ◽

1963 ◽

Vol 10 (02) ◽

pp. 400-405 ◽

Cited By ~ 4

Author(s):

B. A Amundson ◽

L. O Pilgeram

Keyword(s):

Blood Coagulation ◽

Methyl Ether ◽

Broad Spectrum ◽

Human Subjects ◽

Plasma Fibrinogen ◽

Steroid Metabolism ◽

Specific Site ◽

Chain Reaction ◽

Normal Human ◽

A Chain

SummaryEnovid (5 mg norethynodrel and 0.075 mg ethynylestradiol-3-methyl ether) therapy in young normal human subjects causes an increase in plasma fibrinogen of 32.4% (P >C 0.001). Consideration of this effect together with other effects of Enovid on the activity of specific blood coagulatory factors suggests that the steroids are exerting their effect at a specific site of the blood coagulation and/or fibrinolytic system. The broad spectrum of changes which are induced by the steroids may be attributed to a combination of a chain reaction and feed-back control.

Download Full-text

Relationship Between Mepacrine-Labelled Dense Body Number, Platelet Capacity to Accumulate 14C-5-HT and Platelet Density in the Bernard-Soulier and Hermansky-Pudlak Syndromes

Thrombosis and Haemostasis ◽

10.1055/s-0038-1666908 ◽

1979 ◽

Vol 42 (02) ◽

pp. 694-704 ◽

Cited By ~ 31

Author(s):

F Rendu ◽

A T Nurden ◽

M Lebret ◽

J P Caen

Keyword(s):

Dense Body ◽

Human Subjects ◽

Human Platelets ◽

Dense Bodies ◽

Storage Organelle ◽

Hereditary Disorders ◽

Labelling Procedure ◽

Normal Human ◽

Hermansky Pudlak Syndrome ◽

Bernard Soulier Syndrome

SummaryWe have used the mepacrine-labelling procedure to measure the dense body (serotonin storage organelle) content of the platelets of 2 hereditary disorders where abnormalities in dense body number were suspected. The platelets were incubated with mepacrine and examined by fluorescence microscopy. A mean number of 5.4 ± 0.8 (SD) dense bodies per platelet was calculated from the data obtained using platelets isolated from 40 normal human subjects. In contrast the platelets of 2 patients with the Bernard-Soulier syndrome contained an average of 14 and 17 labelled granules. This increase was associated with a much greater capacity of the platelets to accumulate 14C-5-HT. The opposite result was obtained using the platelets from 2 patients with the Hermansky-Pudlak syndrome which contained few granules labelled by mepacrine and took up less 14C-5-HT than normal human platelets. Centrifugation of the patients’ platelets on discontinuous sucrose gradients showed that the platelets of the 2 Bemard-Soulier patients were much denser than normal whereas a high proportion of low density platelets was observed in the Hermansky-Pudlak syndrome. These results further define the platelet abnormalities in the two syndromes and suggest that dense body number may be one of the factors governing platelet density.

Download Full-text