scholarly journals Palladium-catalyzed substitution of (coumarinyl)methyl acetates with C-, N-, and S-nucleophiles

2012 ◽  
Vol 8 ◽  
pp. 1200-1207 ◽  
Author(s):  
Kalicharan Chattopadhyay ◽  
Erik Fenster ◽  
Alexander J Grenning ◽  
Jon A Tunge
Keyword(s):  
Nucleophilic Substitution ◽  
Biologically Active ◽  
New Method ◽  
Biological Screening ◽  
Different Types ◽  
Reaction Proceeds ◽  
Palladium Catalyzed

The palladium-catalyzed nucleophilic substitution of (coumarinyl)methyl acetates is described. The reaction proceeds though a palladium π-benzyl-like complex and allows for many different types of C-, N-, and S-nucleophiles to be regioselectively added to the biologically active coumarin motif. This new method was utilized to prepare a 128-membered library of aminated coumarins for biological screening.

ISOLEMENT ET QUELQUES CARACTERISTIQUES D'UNE GONADOTROPHINE URINAIRE DE MÉNOPAUSE HOMOGÈNE A L'ELECTROPHORÈSE

1960 ◽  
Vol XXXV (II) ◽  
pp. 225-234 ◽  
Author(s):  
R. Bourrillon ◽  
R. Got ◽  
R. Marcy
Keyword(s):  
Sialic Acid ◽  
Histological Study ◽  
Active Material ◽  
Biologically Active ◽  
New Method ◽  
Female Rats ◽  
Mouse Uterus ◽  
Highly Active ◽  
Zone Electrophoresis ◽  
Human Menopausal Gonadotrophin

ABSTRACT A new method for preparation of Human Menopausal Gonadotrophin involves successively alcoholic precipitation, kaolin adsorption and chromatography on ion exchangers. A highly active material is obtained which corresponds to 1 mg per litre of urine and has an activity of 1 mouse uterus unit at a dose of 0.003 mg. This gonadotrophin possesses both follicle stimulating and luteinizing activities in hypophysectomized female rats, by histological study. It contains 13 % hexose, 10% hexosamine and 8.5 % sialic acid. A further purification, by zone electrophoresis on starch, gives a final product, biologically active at 0.001 mg, which behaves as an homogenous substance in free electrophoresis with mobility −4.76 × 10−5 at pH 8.6.

Intermolecular C–H Amidation of Alkenes with Carbon Monoxide and Azides via Tandem Palladium Catalysis

Synthesis ◽  
2021 ◽  
Author(s):  
Zheng-Yang Gu ◽  
Yang Wu ◽  
Feng Jin ◽  
Bao Xiaoguang ◽  
Ji-Bao Xia
Keyword(s):  
Carbon Monoxide ◽  
Palladium Catalysis ◽  
Computational Studies ◽  
Organic Azides ◽  
Reaction Proceeds ◽  
Palladium Catalyzed ◽  
Directing Group ◽  
And Control

An atom- and step-economic intermolecular multi-component palladium-catalyzed C–H amidation of alkenes with carbon monoxide and organic azides has been developed for the synthesis of alkenyl amides. The reaction proceeds efficiently without an ortho-directing group on the alkene substrates. Nontoxic dinitrogen is generated as the sole by-product. Computational studies and control experiments have revealed that the reaction takes place via an unexpected mechanism by tandem palladium catalysis.

Palladium-Catalyzed Carbonylative Synthesis of Aryl Esters from p-Benzoquinones and Aryl Triflates

2021 ◽  
Author(s):  
Xiao-Feng Wu ◽  
jun ying ◽  
Jian-Shu Wang ◽  
Zhengjie Le ◽  
Siqi Wang
Keyword(s):  
Reaction Proceeds ◽  
Palladium Catalyzed

A palladium-catalyzed dicarbonylation of p-benzoquinones with aryl triflates has been developed. Using Cr(CO)6 as the CO source, the reaction proceeds smoothly and efficiently to give a series of aryl esters...

scholarly journals Palladium-catalyzed Tsuji–Trost-type reaction of benzofuran-2-ylmethyl acetates with nucleophiles

RSC Advances ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 909-917
Author(s):  
Antonio Arcadi ◽  
Giancarlo Fabrizi ◽  
Andrea Fochetti ◽  
Francesca Ghirga ◽  
Antonella Goggiamani ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Type Reaction ◽  
Palladium Catalyzed

The palladium-catalyzed benzylic-like nucleophilic substitution of benzofuran-2-ylmethyl acetate with N, S, O and C soft nucleophiles.

A New Method To Generate Arene-Terminated Si(111) and Ge(111) Surfaces via a Palladium-Catalyzed Arylation Reaction

2012 ◽  
Vol 134 (50) ◽  
pp. 20433-20439 ◽  
Author(s):  
Yoshinori Yamanoi ◽  
Junya Sendo ◽  
Tetsuhiro Kobayashi ◽  
Hiroaki Maeda ◽  
Yusuke Yabusaki ◽  
...  
Keyword(s):  
New Method ◽  
Palladium Catalyzed

Performance assessment of the complex repairable system with n-identical units under (k-out-of-n: G) scheme and copula linguistic repair approach

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
V. V. Singh ◽  
Abubakkar Idris Mohhammad ◽  
Kabiru Hamisu Ibrahim ◽  
Ibrahim Yusuf
Keyword(s):  
Complex System ◽  
Design Methodology ◽  
New Method ◽  
Social Implications ◽  
Repairable System ◽  
Variable Technique ◽  
Content Type ◽  
Different Types ◽  
Theoretical Assessment ◽  
Practical Implications

PurposeThis paper analyzed a complex system consisting n-identical units under a k-out-of-n: G; configuration via a new method which has not been studied by previous researchers. The computed results are more supportable for repairable system performability analysis.Design/methodology/approachIn this paper, the authors have analyzed a complex system consisting n-identical units under a k-out-of-n: G; configuration via a new method which has not been studied by previous researchers. The supplementary variable technique has employed for analyzing the performance of the system.FindingsReliability measures have been computed for different types of configuration. It generalized the results for purely series and purely parallel configurations.Research limitations/implicationsThis research may be beneficial for industrial system performances whereas a k-out-of-n-type configuration exists.Practical implicationsNot sure as it is a theoretical assessment.Social implicationsThis research may not have social implications.Originality/valueThis work is the sole work of authors that have not been communicated to any other journal before.

scholarly journals Palladium-Catalyzed Coupling Reactions on Functionalized 2-Trifluoromethyl-4-chromenone Scaffolds: Synthesis of Highly Functionalized Trifluoromethyl Heterocycles

Synthesis ◽  
2018 ◽  
Vol 51 (06) ◽  
pp. 1342-1352 ◽  
Author(s):  
Javier Izquierdo ◽  
Atul Jain ◽  
Sarki Abdulkadir ◽  
Gary Schiltz
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Biological Activities ◽  
Structural Complexity ◽  
Biologically Active ◽  
Coupling Reactions ◽  
Trifluoromethyl Group ◽  
Palladium Catalyzed ◽  
Active Natural

The chromenone core is an ubiquitous group in biologically active natural products and has been extensively used in organic synthesis. Fluorine-derived compounds, including those with a trifluoromethyl group (CF3), have shown enhanced biological activities in numerous pharmaceuticals compared with their non-fluorinated analogues. 2-Trifluoromethylchromenones can be readily functionalized at the 8- and 7-positions, providing chromenones cores of high structural complexity, which are excellent precursors for numerous trifluoromethyl heterocycles.

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