Dibenzocyclooctadiene Lignans from Artemisia sieversiana and Their Nitric Oxide Inhibitory Effects

Two previously undescribed dibenzocyclooctadiene lignans, named sieverlignans D–E (1-2), as well as eight known ones (3-10), were isolated from the aerial parts of Artemisia sieversiana. Their structures were elucidated from extensive spectroscopic analysis, including HRMS, NMR and circular dichroism experiments. This study is the first to report dibenzocyclooctadiene lignans in the genus Artemisia and this plant. All the compounds were evaluated for their anti-neuroinflammatory effects on the lipopolysaccharides (LPS)-induced nitric oxide production in BV-2 murine microglial cells. Compounds 1 and 6 exhibited the moderate activity with their IC50 values of 47.7 and 21.9 μM, compared to a positive control quercetin with the IC50 value of 16.0 μM.

Download Full-text

Anti-inflammatory Flavanones and Flavanols from the Roots of Pongamia pinnata

Planta Medica ◽

10.1055/a-0626-7356 ◽

2018 ◽

Vol 84 (16) ◽

pp. 1174-1182 ◽

Cited By ~ 1

Author(s):

Ran Wen ◽

Haining Lv ◽

Yong Jiang ◽

Pengfei Tu

Keyword(s):

Nitric Oxide ◽

Circular Dichroism ◽

Pongamia Pinnata ◽

Nitric Oxide Production ◽

Inhibitory Effects ◽

Circular Dichroism Spectra ◽

Electronic Circular Dichroism ◽

Oxide Production ◽

Anti Inflammatory ◽

Circular Dichroïsm

AbstractA phytochemical study of the roots of Pongamia pinnata afforded 29 flavanones and flavanols, including 7 previously undescribed compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and mass spectroscopy data. The absolute configurations of the compounds were assigned via analysis of the specific rotations and electronic circular dichroism spectra, application of Mosherʼs method, and by comparing the calculated and experimental electronic circular dichroism spectra. The isolates were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells. All of the isolated compounds exhibited inhibitory effects against nitric oxide production, and most of them showed obvious anti-inflammatory activities (IC50 < 20 µM), among which 26 was the most active compound with an IC50 of 9.6 µM.

Download Full-text

Reactive Oxygen Species-Dependent Nitric Oxide Production in Reciprocal Interactions of Glioma and Microglial Cells

Journal of Cellular Physiology ◽

10.1002/jcp.24659 ◽

2014 ◽

Vol 229 (12) ◽

pp. 2015-2026 ◽

Cited By ~ 21

Author(s):

Shing-Chuan Shen ◽

Ming-Shun Wu ◽

Hui-Yi Lin ◽

Liang-Yo Yang ◽

Yi-Hsuan Chen ◽

...

Keyword(s):

Nitric Oxide ◽

Reactive Oxygen Species ◽

Reactive Oxygen ◽

Microglial Cells ◽

Nitric Oxide Production ◽

Oxygen Species ◽

Reciprocal Interactions ◽

Oxide Production

Download Full-text

Two dimeric lignans with an unusual α,β-unsaturated ketone motif from Zanthoxylum podocarpum and their inhibitory effects on nitric oxide production

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.10.135 ◽

2011 ◽

Vol 21 (1) ◽

pp. 373-376 ◽

Cited By ~ 22

Author(s):

Xiao-Jiang Zhou ◽

Xiao-Liang Chen ◽

Xue-Song Li ◽

Jia Su ◽

Jiang-Bo He ◽

...

Keyword(s):

Nitric Oxide ◽

Unsaturated Ketone ◽

Nitric Oxide Production ◽

Inhibitory Effects ◽

Oxide Production

Download Full-text

Diterpenoids and Diacetylenes from the Roots of Aralia cordata with Inhibitory Effects on Nitric Oxide Production

Journal of Natural Products ◽

10.1021/acs.jnatprod.0c00842 ◽

2021 ◽

Vol 84 (2) ◽

pp. 230-238

Author(s):

Jun Gu Kim ◽

Jin Woo Lee ◽

Thi Phuong Linh Le ◽

Jae Sang Han ◽

Haeun Kwon ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Production ◽

Inhibitory Effects ◽

Aralia Cordata ◽

Oxide Production

Download Full-text

Polyphenols from Sophora yunnanensis, and Their Inhibitory Effects on Nitric Oxide Production

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.59.1567 ◽

2011 ◽

Vol 59 (12) ◽

pp. 1567-1569 ◽

Cited By ~ 8

Author(s):

Akihiro Daikonya ◽

Susumu Kitanaka

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Production ◽

Inhibitory Effects ◽

Oxide Production

Download Full-text

Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata

Planta Medica ◽

10.1055/s-0043-114736 ◽

2017 ◽

Vol 83 (17) ◽

pp. 1368-1373 ◽

Cited By ~ 10

Author(s):

Miao Dong ◽

Li-Qiu Quan ◽

Wei-Feng Dai ◽

Shi-Li Yan ◽

Chin-Ho Chen ◽

...

Keyword(s):

Nitric Oxide ◽

Ethanol Extract ◽

Moderate Activity ◽

Nitric Oxide Production ◽

X Ray Diffraction ◽

Oxide Production ◽

New Compounds ◽

Anti Hiv ◽

Hiv 1

AbstractThree new compounds (1 – 3), including a sesterterpenoid, aspterpenacid C (1), with an unusual 5/3/7/6/5 pentacyclic skeleton, together with seven known ones (4 – 10), were isolated from the ethanol extract of the traditional Chinese medicinal plant Swertia bimaculata. Their structures were elucidated on the basis of the methods of spectroscopic NMR, MS, and computational chemistry. The structure of 1 was further confirmed by single-crystal X-ray diffraction analysis. Compounds 1 – 10 were tested for activities on the inhibition of nitric oxide production and HIV-1 replication in vitro. Compound 1 exhibited moderate activity in inhibiting nitric oxide production (IC50 = 16.1 µM) and HIV-1 replication (EC50 = 1.35 µM).

Download Full-text

Fluoxetine increases the nitric oxide production via nuclear factor kappa B-mediated pathway in BV2 murine microglial cells

Neuroscience Letters ◽

10.1016/j.neulet.2005.12.022 ◽

2006 ◽

Vol 397 (3) ◽

pp. 185-189 ◽

Cited By ~ 37

Author(s):

Eunyoung Ha ◽

Kyung Hee Jung ◽

Bong-Keun Choe ◽

Jae-Hoon Bae ◽

Dong-Hoon Shin ◽

...

Keyword(s):

Nitric Oxide ◽

Nuclear Factor Kappa B ◽

Microglial Cells ◽

Nitric Oxide Production ◽

Nuclear Factor ◽

Nuclear Factor Kappa ◽

Oxide Production

Download Full-text

Diarylheptanoids of Curcuma comosa with Inhibitory Effects on Nitric Oxide Production in Macrophage RAW 264.7 Cells

Natural Product Communications ◽

10.1177/1934578x1501000123 ◽

2015 ◽

Vol 10 (1) ◽

pp. 1934578X1501000 ◽

Cited By ~ 1

Author(s):

Nilubon Sornkaew ◽

Yuan Lin ◽

Fei Wang ◽

Guolin Zhang ◽

Ratchanaporn Chokchaisiri ◽

...

Keyword(s):

Nitric Oxide ◽

Inhibitory Activity ◽

Raw 264.7 Cells ◽

Racemic Mixture ◽

Raw 264.7 ◽

Nitric Oxide Production ◽

Inhibitory Effects ◽

Curcuma Comosa ◽

Oxide Production ◽

Potent Inhibitory Activity

Eight new diarylheptanoids, a 1.2:1 mixture of (3S)- and (3 R)-1-(4-hydroxyphenyl)-7-phenyl-(4 E,6 E)-4,6-heptadien-3-ol (1a and 1b), a racemic mixture of (3S)- and (3 R)-1-(4-hydroxyphenyl)-3-methoxy-7-phenyl-(4 E,6 E)-4,6-heptadiene (2a and 2b), a ca. 1:1 mixture of (3S)- and (3 R)-1-(4-hydroxy-3-methoxyphenyl)-3-methoxy-7-phenyl)-(4 E,6 E)-4,6-heptadiene (3a and 3b), 3-acetoxy-1-(3,4-dihydroxyphenyl)-7-phenylheptan-5-ol (4), (3 R)-1-(4,5-dihydroxyphenyl)-7-phenyl-(6 E)-6-hepten-3,2′-epoxide (5), and thirteen known diarylheptanoids, 6-12, a 3:1 mixture of 13a and 13b, and 14-17, were isolated from the rhizomes of Curcuma comosa from Sakon Nakhon, northeastern part of Thailand. The isolated compounds were evaluated for their antiinflammatory activities on the inhibition of lipopolysaccharide-induced nitric oxide production in macrophage RAW 264.7 cells and the diarylheptanoids 1a and 1b mixture and 14 exhibited potent inhibitory activity.

Download Full-text