scholarly journals Gabapentin for phantom limb pain after amputation in pediatric oncology: a systematic review protocol

2020 ◽  
Author(s):  
Shuang Jiang ◽  
Meng-meng Zhou ◽  
Rong Xia ◽  
Jing-hui Bai ◽  
Li-hua Yan
Keyword(s):  
Systematic Review ◽  
Pediatric Oncology ◽  
Phantom Limb Pain ◽  
Phantom Limb ◽  
Systematic Review Protocol ◽  
Limb Pain ◽  
Review Protocol

scholarly journals Gabapentin for phantom limb pain after amputation in pediatric oncology: a systematic review protocol

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Shuang Jiang ◽  
Meng-meng Zhou ◽  
Rong Xia ◽  
Jing-hui Bai ◽  
Li-hui Yan
Keyword(s):  
Systematic Review ◽  
Pediatric Oncology ◽  
Phantom Limb Pain ◽  
Outcome Data ◽  
Mean Difference ◽  
Biomedical Literature ◽  
Phantom Limb ◽  
Efficacy And Safety ◽  
Limb Pain

Abstract Background Phantom limb pain (PLP) is a prevalent problem for children after amputation because of the chemotherapy treatment. Gabapentin is a potential option to manage PLP after amputation in pediatric oncology. However, no systematic review specifically investigated this topic. Thus, this study aims to appraise the efficacy and safety of gabapentin for post-amputation PLP in pediatric oncology. Methods Electronic databases (Cochrane Library, MEDLINE, EMBASE, Web of Science, CINAHL, PsychINFO, Scopus, WANGFANG, and Chinese Biomedical Literature Database) will be systematically searched from the beginning to the present without limitations to publication status and language. Primary outcome is pain intensity. Secondary outcomes are analgesic drug consumption, sleep quality, depression, anxiety, health-related quality of life, and adverse events. The treatment effect of all dichotomous outcome data will be estimated as risk ratio and 95% confidence intervals (CIs) and that of continuous outcome data will be calculated as mean difference or standardized mean difference and 95% CIs. Methodological quality of randomized controlled trials (RCTs) will be assessed using Cochrane risk of bias tool and that of case-controlled studies (CCSs) will be appraised using Newcastle-Ottawa Tool. Statistical analysis will be conducted using RevMan 5.3 software. Discussion This study will summarize up-to-date high-quality RCTs and CCSs to assess the efficacy and safety of gabapentin for PLP after amputation in pediatric oncology. The findings of this study will help to determine whether or not gabapentin is effective and safe for children with PLP after amputation. Systematic review registration INPLASY202060090

A systematic review on the treatment of phantom limb pain with spinal cord stimulation

2017 ◽  
Vol 7 (1) ◽  
pp. 59-69 ◽  
Author(s):  
Rohit Aiyer ◽  
Robert L Barkin ◽  
Anurag Bhatia ◽  
Semih Gungor
Keyword(s):  
Systematic Review ◽  
Spinal Cord ◽  
Spinal Cord Stimulation ◽  
Phantom Limb Pain ◽  
Phantom Limb ◽  
Limb Pain

Effectiveness of mirror therapy, motor imagery, and virtual feedback on phantom limb pain following amputation: A systematic review

2017 ◽  
Vol 42 (3) ◽  
pp. 288-298 ◽  
Author(s):  
Laura Herrador Colmenero ◽  
Jose Manuel Perez Marmol ◽  
Celia Martí-García ◽  
María de los Ángeles Querol Zaldivar ◽  
Rosa María Tapia Haro ◽  
...  
Keyword(s):  
Systematic Review ◽  
Motor Imagery ◽  
Visual Feedback ◽  
Methodological Quality ◽  
Internal Validity ◽  
Phantom Limb Pain ◽  
Research Quality ◽  
Phantom Limb ◽  
Mirror Therapy ◽  
Limb Pain

Background: Phantom limb pain is reported in 50%–85% of people with amputation. Clinical interventions in treating central pain, such as mirror therapy, motor imagery, or virtual visual feedback, could redound in benefits to amputee patients with phantom limb pain. Objectives: To provide an overview of the effectiveness of different techniques for treating phantom limb pain in amputee patients. Study design: Systematic review. Methods: A computerized literature search up to April 2017 was performed using the following databases: PubMed, Scopus, CINAHL, MEDLINE, ProQuest, PEDro, EBSCOhost, and Cochrane Plus. Methodological quality and internal validity score of each study were assessed using PEDro scale. For data synthesis, qualitative methods from the Cochrane Back Review Group were applied. Results: In all, 12 studies met our inclusion criteria, where 9 were rated as low methodological quality and 3 rated moderate quality. All studies showed a significant reduction in pain, but there was heterogeneity among subjects and methodologies and any high-quality clinical trial (PEDro score ≤8; internal validity score ≤5) was not found. Conclusion: Mirror therapy, motor imaginary, and virtual visual feedback reduce phantom limb pain; however, there is limited scientific evidence supporting their effectiveness. Future studies should include designs with more solid research methods, exploring short- and long-term benefits of these therapies. Clinical relevance This systematic review investigates the effectiveness of mirror therapy, motor imagery, and virtual visual feedback on phantom limb pain, summarizing the currently published trials and evaluating the research quality. Although these interventions have positive benefits in phantom limb pain, there is still a lack of evidence for supporting their effectiveness.

scholarly journals The prevalence and risk factors for phantom limb pain in people with amputations: A systematic review and meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. e0240431
Author(s):  
Katleho Limakatso ◽  
Gillian J. Bedwell ◽  
Victoria J. Madden ◽  
Romy Parker
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Meta Analysis ◽  
Phantom Limb Pain ◽  
Phantom Limb ◽  
Limb Pain

scholarly journals The prevalence and risk factors for phantom limb pain in people with amputations: a systematic review and meta-analysis

2019 ◽  
Author(s):  
K. Limakatso ◽  
G. J. Bedwell ◽  
V. J. Madden ◽  
R. Parker
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Health Care Professionals ◽  
Meta Analysis ◽  
Grey Literature ◽  
Phantom Limb Pain ◽  
Phantom Limb ◽  
Limb Pain ◽  
Amputation Stump ◽  
Proximal Site

Background and objectivePhantom limb pain (PLP) is a common complication in people with limb amputations. There are conflicting reports in the literature regarding the prevalence of PLP in people with limb amputations. Therefore, this review aimed to determine the estimated pooled prevalence of PLP, and risk factors associated with this complication.MethodsArticles published between 1980 and July 2019 were identified through a systematic search of the following electronic databases: MEDLINE/PubMed, PsycINFO, PsycArticles, Cumulative Index to Nursing and Allied Health Literature, Africa−Wide Information, Health Source: Nursing/Academic Edition, SCOPUS, Web of Science and Academic Search Premier. Grey literature was searched on databases for preprints. Two reviewers independently performed the screening of articles, data extraction and risk of bias assessment. The meta−analyses were conducted using the random−effects model. A statistically significant level for the analyses was set at p>0.05.ResultsThe pooling of all studies demonstrated a prevalence estimate of 63% [95% CI: 58.23−67.05] with high heterogeneity [I2=95.70% (95% CI: 95.10−96.20)]. The prevalence of PLP was significantly lower in developing countries compared to developed countries [53.98% vs 64.55%; p=0.04]. Persistent pre−operative pain, proximal site of amputation, lower limb amputation, stump pain and phantom sensations were identified as risk factors for PLP.ConclusionThis systematic review and meta−analysis estimates that six of every 10 people with an amputation report PLP − a high and important prevalence of PLP. Health care professionals ought to be aware of the high rates of PLP and implement strategies to reduce PLP by addressing known risk factors, specifically those identified by the current study.

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