scholarly journals The Cytotoxic Effect of Rtks Inhibitors on Glioblastoma Cells. A Mathematical Model for Treatment Protocols Optimization

2020 ◽  
Vol 71 (2) ◽  
pp. 115-120
Author(s):  
Corina Brandusa ◽  
Bogdan-Ionel Vatu ◽  
Stefana Oana Purcaru ◽  
Stefan-Alexandru Artene ◽  
Sandra Alice Buteica ◽  
...  

Medical oncology has seen an exponential growth in the last 20 years with the vast majority of malignancies receiving new therapeutic options with substantial benefits to patients� survival and quality of life. Glioblastomas (GBMs), however, have remained largely incurable, with over 90% of patients dying within 5 years of diagnosis. The estimation of a dose�effect type ratio, regarding the action of an oncological drug on tumor cells, leads to relevant conclusions in establishing the optimal medication, specific to the chemotherapeutic act. The identification of the optimal dose of agent is very important, based on experiments on cell lines with regards to cellular kinetics. In this study, we developed a mathematical model based on the specific transfer function of a dose�response action type of a drug on tumor cells in vitro.

2017 ◽  
Vol 44 (3) ◽  
pp. 0307001
Author(s):  
杨 曼 Yang Man ◽  
邢力允 Xing Liyun ◽  
高卫栋 Gao Weidong ◽  
顾月清 Gu Yueqing

2019 ◽  
Vol 2 (4) ◽  
pp. 83-98 ◽  
Author(s):  
André De Lima Mota ◽  
Bruna Vitorasso Jardim-Perassi ◽  
Tialfi Bergamin De Castro ◽  
Jucimara Colombo ◽  
Nathália Martins Sonehara ◽  
...  

Breast cancer is the most common cancer among women and has a high mortality rate. Adverse conditions in the tumor microenvironment, such as hypoxia and acidosis, may exert selective pressure on the tumor, selecting subpopulations of tumor cells with advantages for survival in this environment. In this context, therapeutic agents that can modify these conditions, and consequently the intratumoral heterogeneity need to be explored. Melatonin, in addition to its physiological effects, exhibits important anti-tumor actions which may associate with modification of hypoxia and Warburg effect. In this study, we have evaluated the action of melatonin on tumor growth and tumor metabolism by different markers of hypoxia and glucose metabolism (HIF-1α, glucose transporters GLUT1 and GLUT3 and carbonic anhydrases CA-IX and CA-XII) in triple negative breast cancer model. In an in vitro study, gene and protein expressions of these markers were evaluated by quantitative real-time PCR and immunocytochemistry, respectively. The effects of melatonin were also tested in a MDA-MB-231 xenograft animal model. Results showed that melatonin treatment reduced the viability of MDA-MB-231 cells and tumor growth in Balb/c nude mice (p <0.05). The treatment significantly decreased HIF-1α gene and protein expression concomitantly with the expression of GLUT1, GLUT3, CA-IX and CA-XII (p <0.05). These results strongly suggest that melatonin down-regulates HIF-1α expression and regulates glucose metabolism in breast tumor cells, therefore, controlling hypoxia and tumor progression. 


1984 ◽  
Vol 104 (4_Supplb) ◽  
pp. S55-S56 ◽  
Author(s):  
W. LUSTER ◽  
C. GROPP ◽  
H. F. KERN ◽  
K. HAVEMANN

Author(s):  
S. Nikolaev ◽  
L. Andreenko

In modern poultry farming the most urgent tasks are to search for and test new environmentally safe feed and economically justifi ed additives that stimulate productivity, positively aff ect the health of poultry, and consequently increase the livability of livestock and other important zootechnical traits. In order to maintain physiologically normal processes of life, metabolism and increase the level of productivity of poultry it needs mineral components and their chelated compounds. The purpose of this work was to increase the egg productivity of poultry by using the silicon-containing poly additive Nabicat in feeding young hens and laying hens. The researches have been carried out on the poultry cross Highsex Brown under the environments in CJSC “Poultry Farm “Volzhskaya” in the Sredneakhtubinsky area in the Volgograd region. In this paper, The optimal dose of the introduction of the silicon-containing poly additive Nabicat in the diets of young and laying hens of the cross Highsex Brown has been scientifi cally justifi ed and the biological value of using an organic form of silicon has been determined. The positive infl uence of the optimal dose of poly additive on growth, consumption, and digestibility, nutrient metabolism in the poultry body, as well as egg productivity and quality of the resulting egg has been revealed. Thus, the average egg productivity per 1 hen in the control group during the experiment period was 321,3 pcs., and in the 1st, 2nd and 3rd experimental groups it was 322,6 pcs., 325,8 and 325,7 pcs., which was higher than in the control group by 0,40 %, 1,40 and 1,37 %, respectively. The average egg weight in the 1st experimental group exceeded the control by 0,43 g or 0,68 %, in the 2nd experimental group by 1,16 g or 1,84 %, in the 3rd experimental group by 0,81 g or 1,28 %. The economic eff ectiveness of using the organic silicon additive in the composition of Nabicat poly additive in the feeding of laying hens has been proved. The economic eff ect due to the use of diff erent doses of the introduction of silicon-containing poly additive Nabicat in compound feed for laying hens of the 1st experimental group was 141,66 rubles, the 2nd experimental group 962,76 rubles, and the 3rd experimental group 821,89 rubles.


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