In this paper the process of direct reduction of vanadium slag was adopted. The main factor was determined by uniform experimental design and single factor analysis, and then the optimum process condition was drawn by the test. The test results showed that the regression equation curve fitting of the experiment data was very significant, the main factors affecting the vanadium slag reduction (according to the primary and secondary order) was the content of anhydrous sodium carbonate, roasting temperature, roasting time and reduction of carbon content. The factors for the reduction of the optimum process conditions are the carbon coefficient 1.04, roasting temperature 1100°C, roasting reduction time 4h, 4% mass percent of anhydrous sodium carbonate and slag. Under the optimum conditions, the actual rate of weight loss and theory rate of weight were close to 0, the results could be reproduced, and the vanadium slag metallization rate was 75%~83%.