scholarly journals History of the Rhesus factor and of neonatal jaundice

2021 ◽  
Vol 16 (S4) ◽  
pp. 7-10
Author(s):  
Vlad DIMA ◽  
◽  
Andreea CALOMFIRESCU-AVRAMESCU ◽  
Ana Maria Alexandra STĂNESCU ◽  
Anca A. SIMIONESCU ◽  
...  
Keyword(s):  
Blood Group ◽  
Neonatal Jaundice ◽  
Metabolic Diseases ◽  
Fetal Anemia ◽  
Hemolytic Disease ◽  
Non Invasive ◽  
Rhesus Factor ◽  
Antigen Transfer ◽  
History Of ◽  
Rh Blood Group

The history of icterus and neonatal jaundice has been recorded since the 17th century, when a French midwife first described jaundice (jaune) in twins. In 1940, Alexander Wiener and Karl Landsteiner discovered the Rh blood group, and they investigated the isoimmunization via antigen transfer across the placenta from the fetus. Other blood group systems implicated in isoimmunization were discovered between 1901 and 1965. Between 1940-1960, many studies have focused on the etiology of hemolytic disease of the newborn, on incompatibility in the Rh system, cholestasis, metabolic diseases, inhibitors of breast milk, and the association between prematurity and jaun-dice or extremely nuclear jaundice. It is the merit of AW Liley, in 1963, who described the diagram of the same name based on the level of bilirubin in the amniotic fluid and who performed the first fetal transfusions for fetal anemia. Last decades, non-invasive methods of diagnosis and treatment were described.

scholarly journals Assessment of Correlations Between Neonatal Jaundice and Phototherapy With Childhood Diabetes Type 1

2020 ◽  
Author(s):  
Mehri Ayati ◽  
Amir Hossein Movahedian ◽  
Ziba Mosayebi
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Blood Group ◽  
Neonatal Jaundice ◽  
Control Group ◽  
Case Group ◽  
History Of ◽  
Group A ◽  
Childhood Type

Previous investigations have indicated an association between modulation of developing the immune system with increased risk of autoimmune diseases such as type 1 Diabetes Mellitus (T1DM). Objectives: In the present study, we aimed to evaluate correlations between the positive history of blood group incompatibility, neonatal jaundice, and phototherapy with childhood type 1 DM. A case-control retrospective study was carried out in an Iranian Hospital in 2015. One-hundred subjects aged 1-15 years with T1DM were included as the case group. One-hundred healthy children were also considered as the control group. A questionnaire composed of demographic-clinical data was completed for each subject. Correlations between childhood type 1diabetes and some clinical risk factors were determined. One hundred cases with type 1 diabetes and 100 healthy control children entered the study. A significant association between maternal gestational diabetes mellitus and childhood T1DM was observed (P=0.05, OR=3.789). The history of neonatal jaundice in the case group was significantly higher than in the control group (P=0.02, OR=4.667). ABO incompatibilities in the case group were associated with 19 neonates with blood group A and 2 neonates with blood group B (mothers' blood group; O) (P=0.005, OR=7.397). In the case group, 29 of 38 cases with a history of jaundice had received phototherapy while in the control group, 19 participants had undergone phototherapy (P=0.126, OR=1.707). Results have indicated that neonatal Jaundice and ABO incompatibility could increase the risk of childhood T1DM. Moreover, maternal GDM should be considered as an increased subsequent risk of childhood T1D.

scholarly journals Severe hemolytic disease of the premature newborn due to RH1 incompatibility: a case report

2016 ◽  
Vol 89 (4) ◽  
pp. 565-568 ◽  
Author(s):  
Jean Uwingabiye ◽  
Hafid Zahid ◽  
Fayçal Labrini ◽  
Abdelhak El Khazraji ◽  
Anass Yahyaoui ◽  
...  
Keyword(s):  
Blood Group ◽  
Serum Bilirubin ◽  
Serum Bilirubin Level ◽  
Total Serum ◽  
Hemolytic Disease ◽  
Close Collaboration ◽  
Haemolytic Disease ◽  
Total Serum Bilirubin Level ◽  
Antiglobulin Test ◽  
History Of

We report a case of dramatic outcome of severe haemolytic disease in a newborn due to RH1 incompatibility. A newborn with A RH1 blood group was admitted in the Mohammed V Military Teaching Hospital for the problem of hydrops fetalis associated with RH1 incompatibility. The blood group of his mother, aged 31, was AB RH1-negative and that of his 37 year old father was A RH1.The mother had a history of 4 term deliveries, 3 abortions, and 1 living child. There was no prevention by anti-D immunoglobulin postpartum. The mother‘s irregular agglutinin test was positive and the pregnancy was poorly monitored. The laboratory tests of the newborn showed a high total serum bilirubin level (30 mg/L) and macrocytic regenerative anemia (Hemoglobin=4 g/dL, mean corpuscular volume = 183 fL, reticulocytes count =176600/m3). The blood smear showed 1256 erythroblasts per 100 leukocytes, Howell–Jolly bodies and many macrocytes. The direct antiglobulin test was positive. He was transfused with red blood cell concentrates and treated with conventional phototherapy. The evolution was unfavourable; he died three days after the death of his mother. The monitoring of these high-risk pregnancies requires specialized centers and a close collaboration between the gynaecologist and the blood transfusion specialist to strengthen the prevention, as well as clinico-biological monitoring in patients with a history of RH1 fetomaternal alloimunization.

scholarly journals Hemolytic disease of the fetus and newborn: managing the mother, fetus, and newborn

Hematology ◽  
2015 ◽  
Vol 2015 (1) ◽  
pp. 146-151 ◽  
Author(s):  
Meghan Delaney ◽  
Dana C. Matthews
Keyword(s):  
Heart Failure ◽  
Pregnant Women ◽  
Blood Group ◽  
Acute Phase ◽  
Maternal Blood ◽  
Fetal Anemia ◽  
Red Cell ◽  
Hemolytic Disease ◽  
Cell Destruction ◽  
Intrauterine Transfusion

AbstractHemolytic disease of the fetus and newborn (HDFN) affects 3/100 000 to 80/100 000 patients per year. It is due to maternal blood group antibodies that cause fetal red cell destruction and in some cases, marrow suppression. This process leads to fetal anemia, and in severe cases can progress to edema, ascites, heart failure, and death. Infants affected with HDFN can have hyperbilirubinemia in the acute phase and hyporegenerative anemia for weeks to months after birth. The diagnosis and management of pregnant women with HDFN is based on laboratory and radiographic monitoring. Fetuses with marked anemia may require intervention with intrauterine transfusion. HDFN due to RhD can be prevented by RhIg administration. Prevention for other causal blood group specificities is less studied.

scholarly journals Analysis of associations between genetic markers of erythrocytes of ав0, Rh, mn, P, kell blood group systems and arterial hypertension at the Altai Republic population

2012 ◽  
Vol 9 (4) ◽  
pp. 65-68
Author(s):  
M U Ogargov ◽  
T A Mulerova ◽  
S N Filimonov ◽  
F A Luzina ◽  
E G Onishchenko
Keyword(s):  
Relative Risk ◽  
Arterial Hypertension ◽  
Blood Group ◽  
Genetic Markers ◽  
Population Sample ◽  
Ethnic Origin ◽  
Altai Republic ◽  
Epidemiologic Survey ◽  
Rhesus Factor ◽  
Rh Blood Group

Objectives: the aim is to estimate the share of people with AH among the Tubalars and nonindigenous inhabitants of the Altai Republic taking into account a sex, an ethnic origin and to analyze genetic predisposition to the diseases of АВ0, Rh, MN, P, Kell blood group systems. Materials and methods. There was clinico-epidemiologic survey of the Altai Republic population (sample of 935 people, 663 people of them are Tubalars, 272 people are nonindigenous) aged from 18 till 88 years. Arterial hypertension was diagnosed according to criteria of WHO/MOAG of 1999. The study of genetic markers was carried out according to the standard methodology, blood group systems were defined: ABO, «full» Rhesus factor, MN, P, Kell. The sample size of different systems made from 301 to 425 people. The force of association between studied markers and the disease was judged according to the criterion of relative risk. Results. 38,6% Tubalars and 40,8% nonindigenous population were diagnosed with arterial hypertension. The share of people with Rh(+) blood group is larger among Tubalars (94,6%) in comparison with nonindigenous representatives (87,4%; p

Evolutionary history of the Rh blood group-related genes in vertebrates

2000 ◽  
Vol 51 (10) ◽  
pp. 856-862 ◽  
Author(s):  
Takashi Kitano ◽  
Naruya Saitou
Keyword(s):  
Blood Group ◽  
Evolutionary History ◽  
History Of ◽  
Rh Blood Group

scholarly journals Plasmapheresis for the Treatment of Anti-M Alloimmunization in Pregnancy

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Yohei Maki ◽  
Junko Ushijima ◽  
Seishi Furukawa ◽  
Hiroko Inagaki ◽  
Hiroyuki Takenouchi ◽  
...  
Keyword(s):  
Fetal Death ◽  
Intrauterine Fetal Death ◽  
Fetal Anemia ◽  
Severe Anemia ◽  
Hemolytic Disease ◽  
Intrauterine Transfusion ◽  
History Of ◽  
Intrauterine Blood Transfusion ◽  
Antenatal Treatment ◽  
In Pregnancy

Intrauterine transfusion is the standard antenatal treatment for a fetus with severe anemia. Plasmapheresis is an alternative treatment for cases with a history of severe hemolytic disease of the fetus and newborns at less than 20 weeks of gestation. There is only one previous report of plasmapheresis for the anti-M alloimmunization in pregnancy, and we report here on the successful treatment of plasmapheresis for anti-M alloimmunization. A woman with a history of intrauterine fetal death at 24 weeks of gestation due to severe fetal anemia caused by anti-M alloimmunization received plasmapheresis once or twice a week from 14 weeks of gestation onward. An intrauterine blood transfusion was conducted at 28 weeks, and a cesarean section was performed at 31 weeks. The infant had anemia and jaundice but was discharged at day 46. Plasmapheresis may delay the development of fetal anemia and reduce the risk of early and repeat intrauterine transfusion in cases of anti-M alloimmunization in pregnancy.

scholarly journals A Complete Review Article on ABC of Blood Groups

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Purna Singh A ◽  
Shivanand S Rathod ◽  
Praveen K Kodumuru ◽  
Desai JM ◽  
Vaishali Nagose
Keyword(s):  
Blood Group ◽  
Blood Groups ◽  
Hemolytic Disease ◽  
Transfusion Therapy ◽  
Abo Incompatibility ◽  
Grouping Systems ◽  
Rh Blood Group ◽  
Blood Grouping ◽  
Increased Susceptibility

ABO and Rh blood group systems are the most important blood grouping systems from clinical aspect. Determination of blood group is important for blood transfusion therapy, medico-legal purposes, organ transplantation, settlement of paternity disputes etc. Nearly 25 types of blood groups are present. ABO incompatibility between mother and fetus may produce infertility or hemolytic disease of the new born, and persons of certain blood groups have an increased susceptibility to peptic ulcer or gastric cancer. The purpose of this review is to summarize the concepts and origin of ABO and other blood groups systems and Chemistry of Blood group specificity (Glycoproteins found in body fluids).

Severe Hemolytic Disease of Newborn Due to Alloimmune Anti-E Antibodies: A Case Report

2021 ◽  
pp. 097321792110563
Author(s):  
Jarjapu Kireeti ◽  
Nalinikanta Panigrahy ◽  
Vijayanad Jamalpuri ◽  
Surekha A. Devi
Keyword(s):  
Blood Group ◽  
Intravenous Immunoglobulins ◽  
Coombs Test ◽  
Hemolytic Disease ◽  
Abo Incompatibility ◽  
Cell Antibody ◽  
Antibody Panel ◽  
Severe Jaundice ◽  
Positive Direct ◽  
Rh Blood Group

Hemolytic disease in the newborn (HDN) as a cause of early jaundice is mostly due to Rh (D), ABO incompatibility, and rarely due to other minor blood group incompatibility. We report case of Rh anti-E isoimmunization presenting as significant unconjugated jaundice within the 24 h of life. Baby presented with severe jaundice and anemia on day 1 of life. Baby was treated with intensive phototherapy, double volume exchange transfusion (DVET), and intravenous immunoglobulins. On evaluation, both mother and baby had O positive (Rh) blood group; however, the infant showed evidence of severe hemolysis. Positive direct Coombs test (DCT) and 11 cell antibody panel showed anti-E antibodies. This case highlights the importance of early identification and evaluation of HDN in the absence of Rh(D) and ABO incompatibility and possibility of severe hemolysis in Rh anti-E isoimmunization needing DVET.

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