scholarly journals RARE FINDING IN A PATIENT WITH MYCOSIS FUNGOIDES – SENSORIMOTOR AXONAL POLYNEUROPATHY

2017 ◽  
Vol 16 (1) ◽  
pp. 29-33
Author(s):  
Oana Obrisca ◽  
◽  
Alexandru Bardas ◽  
Oana Morari ◽  
Ayghiul Elmi-Mujdaba ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
Peripheral Nerves ◽  
Cell Lymphoma ◽  
Case Reports ◽  
Axonal Neuropathy ◽  
Central Nervous System Involvement ◽  
Cutaneous T Cell Lymphoma ◽  
Rare Finding ◽  
Rare Association ◽  
Axonal Polyneuropathy

We report the case of a 62-year old patient who presented a rare association of Mycosis fungoides, a subtype of cutaneous T-cell lymphoma and sensorimotor axonal neuropathy. Usually, leptomeningeal dissemination and central nervous system involvement are much more frequently encountered in cases of Mycosis fungoides with extracutaneous spread and only few case reports describe the involvement of peripheral nerves. The challenge in our case was to correlate a possible etiopathogenic factor with the polyneuropathy. Although, it was most probably a paraneoplastic manifestation, the associated neuropathy could have had other possible pathogenic mechanisms.

scholarly journals PRO25 Healthcare Resource Use in Mycosis Fungoides-Type Cutaneous T-Cell Lymphoma: Results from a UK-Based Clinician Questionnaire

2020 ◽  
Vol 23 ◽  
pp. S693-S694
Author(s):  
J. Scarisbrick ◽  
F. Schmidt ◽  
M.M. Turini ◽  
P. D'agostino ◽  
D. Summers ◽  
...  
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Resource Use ◽  
Healthcare Resource ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Healthcare Resource Use

Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome

2019 ◽  
pp. 221-246
Author(s):  
Timothy J. Voorhees ◽  
Edith V. Bowers ◽  
Christopher R. Kelsey ◽  
Yara Park ◽  
Anne W. Beaven
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Cutaneous T Cell Lymphoma

scholarly journals Psoriasiform Mycosis Fungoides Involving the Face- A Rare Case Report

2021 ◽  
pp. 94-99
Author(s):  
N. R. Vignesh ◽  
Shreya Srinivasan ◽  
G. Sukanya ◽  
S. Arun Karthikeyan
Keyword(s):  
Case Report ◽  
Mycosis Fungoides ◽  
Rare Case ◽  
Cell Lymphoma ◽  
Punch Biopsy ◽  
Cutaneous T Cell Lymphoma ◽  
Rare Presentation ◽  
Rare Case Report ◽  
Atypical Cells ◽  
The Face

Mycosis fungoides is represented as the most common epidermotropic cutaneous T-cell lymphoma, which is mainly characterized by the proliferation of atypical cells within the epidermis. We report a rare presentation of mycosis fungoides in a 60-year-old male presenting with chronic psoriasiform plaque involving the face. Punch biopsy of the lesion from the forehead was taken for routine histological examination and immunohistochemical stains. Results of biopsy and immunohistochemical findings were consistent with mycosis fungoides and diagnosed as psoriasiform presentation of mycosis fungoides involving the face.

scholarly journals Demonstration of antibodies to human T-cell lymphotropic virus-I tax in patients with the cutaneous T-cell lymphoma, mycosis fungoides, who are seronegative for antibodies to the structural proteins of the virus

Blood ◽  
1996 ◽  
Vol 88 (8) ◽  
pp. 3004-3009 ◽  
Author(s):  
BA Pancake ◽  
EH Wassef ◽  
D Zucker-Franklin
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Mononuclear Cells ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Structural Proteins ◽  
Infected Cell Line ◽  
Cutaneous T Cell Lymphoma ◽  
Serologic Tests ◽  
Human T Cell

Although most patients with the cutaneous T-cell lymphoma, mycosis fungoides (MF), are seronegative for human T-cell lymphotropic virus-I or -II (HTLV-I/II) when tested by assays that measure only antibodies to the viral structural proteins, the majority of such patients harbor HTLV-I-related pol and tax proviral sequences that encode proteins not included in routinely used serologic tests. Tax mRNA has also been detected in their peripheral blood mononuclear cells (PBMC). Therefore, it seemed possible that these patients have antibodies to the tax protein. To investigate this, enzyme-linked immunosorbent assays (ELI-SAs) and Western blot assays were set up, using as antigens the full-length HTLV-I tax cloned from the prototypic HTLV-I-infected cell line, C91PL, and from PBMC of a MF patient, as well as a synthetic peptide made to the carboxy-terminal 20 amino acids of tax-I. Of 60 MF patients whose PBMC were shown to be positive for tax proviral DNA and mRNA, 50 (83%) were shown to have tax antibodies. The antigen derived from the MF patient was most useful in detecting such antibodies. These results demonstrate the need for including other HTLV-related antigens in addition to gag and env in serologic tests used to identify HTLV-infected individuals. The findings underscore the fact that individuals considered seronegative on the basis of currently used tests can be infected with HTLV.

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