The Establishment and Utilization of Patient Derived Xenograft Models of Central Nervous System Metastasis

10.3791/62264 ◽  
2021 ◽  
Author(s):  
Ben Yi Tew ◽  
Bodour Salhia
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Metastasis ◽  
Patient Derived Xenograft ◽  
Xenograft Models

scholarly journals Isolated central nervous system metastasis in pediatric Wilms' tumor: A case report and review of literature

2018 ◽  
Vol 21 ◽  
pp. 78-80
Author(s):  
Mehdi Borni ◽  
Brahim Kammoun ◽  
Fatma Kolsi ◽  
Anis Abdelhedi ◽  
Mohamed Zaher Boudawara
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Wilms Tumor ◽  
Review Of Literature ◽  
Central Nervous System Metastasis

Central nervous system metastasis from endometrial carcinoma: A multi-institution retrospective study

2018 ◽  
Vol 149 ◽  
pp. 196
Author(s):  
M. Kuznicki ◽  
A.V. Castaneda ◽  
S. Mostofizadeh ◽  
E.C. McClung ◽  
K. Matsuo ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Retrospective Study ◽  
Endometrial Carcinoma ◽  
Central Nervous System Metastasis

scholarly journals Central nervous system metastasis from osteosarcoma: Case report and literature review

2018 ◽  
Vol 23 (4) ◽  
pp. 266-269 ◽  
Author(s):  
María Tereza Nieto-Coronel ◽  
Allan David López-Vásquez ◽  
Diana Marroquín-Flores ◽  
Sandy Ruiz-Cruz ◽  
Jorge Luis Martínez-Tláhuel ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Literature Review ◽  
Central Nervous System Metastasis

NIMG-07. BEYOND RANDOM AND NUMERIC LESIONS: DIFFERENT IMAGING PATTERNS OF CENTRAL NERVOUS SYSTEM METASTASIS BASED ON PRIMARY TUMOR LOCATION AND MOLECULAR PROFILE

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi128-vi128
Author(s):  
Júlia Magalhães ◽  
Raquel Moreno ◽  
Jorge Takahashi ◽  
Leandro Lucato ◽  
Carlos Silva
Keyword(s):  
Lung Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Brain Metastasis ◽  
Primary Tumor ◽  
Molecular Profile ◽  
Imaging Findings ◽  
Central Nervous System Metastasis ◽  
Cns Metastasis ◽  
Imaging Characteristics

Abstract The purpose of this exhibit is to discuss different imaging patterns of central nervous system (CNS) metastasis based on their primary cancer site and to review the recent literature of the particularities of CNS metastasis distribution in the era of molecular advancement in oncology. Selected cases extracted from our institutions database will be presented. The cases will be didactically organized to illustrate the most common imaging characteristics and distribution of brain metastasis based on their organ of origin, such as lung, breast, renal, skin, testicle and gastrointestinal tract. (SCHROEDER T. et al., J Neurooncol. 2020). We will also discuss the correlation between tumor imaging findings and genetic profile. We intend to review well-known CNS metastasis imaging patterns, as preferential involvement of the posterior fossa and anatomic watershed areas in cases of lung cancer (TAKANO, K. et al. Neuro-Oncology, 2016) and the rarity of parenchyma metastasis from prostate cancer (HATZOGLOU V. et al, J Neuroimaging. 2014). We will also demonstrate newly described imaging findings in correlation with primary tumors genetic mutations, such as higher incidence of leptomeningeal involvement in triple negative breast cancer and increase in the number of brain lesions in cases of EGFR positive lung cancer. Familiarity with the most prevalent imaging characteristics of central nervous system metastasis helps oncologists and radiologists not to miss out a CNS progression in case of a known tumor, and also helps to direct systemic investigation of a primary tumor when brain metastasis is the initial presentation. The correlation between molecular profile and the most common sites of CNS involvement can help on treatment planning, including brain radiation (Yanagihara TK,et al., Tomography. 2017), and also bring to discussion the mechanisms of tumor dissemination, which can be targets for future treatments.

Encouraging Result of Tamoxifen in a Retinoblastoma Patient with Central Nervous System Metastasis

2003 ◽  
Vol 20 (6) ◽  
pp. 473-476 ◽  
Author(s):  
Nurdan Taçyildiz ◽  
Gülsan Yavuz ◽  
Emel Ünal ◽  
Kaan Gündüz ◽  
Ilhan Günalp ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Metastasis ◽  
Retinoblastoma Patient
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