EBV Positive Gastric Carcinomas and Their Clinicopathological Characteristics

BACKGROUND: The understanding of the etiopathogenesis of gastric carcinoma (GC) can be a base for development of new therapeutic methods to reduce mortality and to increase survival in patients with GC. The percentage of Epstein - Barr virus (EBV) positive gastric carcinomas is uncertain, and the etiologic importance of EBV in the pathogenesis of GC has still not been elucidated. AIM: This study aimed to determine the percentage of EBV associated GC as well as to determine their clinicopathological characteristics. MATERIAL AND METHODS: The study included 80 patients with GC who were analysed for ethnicity, local growth of a tumour (T status), the presence of nodal metastases (N), the presence of distant metastases (M), stage of the disease and degree of carcinoma differentiation. For detection of EBV, immunostainings were performed on tumour tissue and the peripheral non-tumour gastric mucosa. RESULTS: Positive immunostaining with an antibody against EBV was found in 19 (23.75%) of the 80 patients with gastric carcinomas. EBV immunostainings were significantly different in patients with or without metastasis and between patients of Macedonian and Albanian ethnicity (p < 0.0001, p < 0.009, respectively). EBV immunoexpression was significantly associated with the presence of distant metastases and with patients of Albanian ethnicity. CONCLUSION: Association of EBV immunostainings with distant metastasis in patients with GC suggests the influence of EBV infection on the progression of gastric carcinoma. Due to scarce and doubtful literature data on EBV associated GC, further studies are necessary to determine the role of EBV regarding aetiology, treatment and prognosis in patients with EBV associated gastric carcinoma.

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ROLE OF EPSTEIN BARR VIRUS AND GASTRIC CARCINOMA

Revista de la Facultad de Medicina Humana ◽

10.25176/rfmh.v18.n1.1269 ◽

2018 ◽

Vol 18 (1) ◽

Author(s):

Brady Beltrán-Gárate ◽

Jhony A. De La Cruz-Vargas

Keyword(s):

Gastric Carcinoma ◽

Epstein Barr Virus ◽

Barr Virus ◽

Epstein Barr

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Very Low Risk of Lymph Node Metastasis in Epstein-Barr Virus-associated Early Gastric Carcinoma With Lymphoid Stroma

10.21203/rs.3.rs-28289/v1 ◽

2020 ◽

Author(s):

Yuqing Cheng ◽

Xiaoli Zhou ◽

Kequn Xu ◽

Jin Huang ◽

Qin Huang

Keyword(s):

Gastric Carcinoma ◽

Epstein Barr Virus ◽

Early Gastric Carcinoma ◽

Invasion Depth ◽

Gastric Carcinomas ◽

Barr Virus ◽

Node Metastasis ◽

Lymphoid Stroma ◽

Poor Differentiation ◽

Epstein Barr

Abstract Epstein-Barr virus-associated early gastric carcinoma with lymphoid stroma (EBV-GCLS) is a rare variant of early gastric carcinomas. Clinicopathological features of this variant remain obscure, especially in Chinese patients. By a retrospective review of 595 consecutive radical gastrectomies for early gastric carcinoma from 2006 to 2018, we identified 8 (1.3%, 8/595) EBV-GCLS cases. Clinicopathologic characteristics were compared between EBV-GCLSs and 109 conventional early gastric carcinomas, which were divided into 3 subgroups, according to the invasion depth. All 8 EBV-GCLSs occurred in male patients and invaded deep submucosa (SM2) without lymph node metastasis (LNM), four (50%) of which had synchronous non-gastric malignant tumors (3 gastric gastrointestinal stromal tumors and 1 primary clear cell renal cell carcinoma), and four (50%) arose in the proximal stomach. Compared to conventional early gastric carcinomas, EBV-GCLS was more frequent with SM2 invasion, poor differentiation, and synchronous non-gastric carcinoma tumor, but not in age, gender, macroscopic type, location, size, perineural invasion, lymphovascular invasion, and pathologic stage. In invasion-depth stratified comparisons with the SM2 subgroup, the frequency of LNM in EBV-GCLS was significantly lower than that of conventional early gastric carcinomas ( p < 0.05) and the 5-year survival rate of patients with EBV-GCLS was better than that of conventional early gastric carcinomas in 3 subgroups (100% vs 91.5%, 85.7%, 83.9%, respectively), although the differences did not reach a statistically significant level due to the small sample size. In conclusion, Even with poor differentiation and SM2 invasion, EBV-GCLS showed very low risk of LNM and may be a candidate for endoscopic therapy.

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The oncogenic role of Epstein-Barr virus-encoded microRNAs in Epstein-Barr virus-associated gastric carcinoma

Journal of Cellular and Molecular Medicine ◽

10.1111/jcmm.13354 ◽

2017 ◽

Vol 22 (1) ◽

pp. 38-45 ◽

Cited By ~ 14

Author(s):

Jinglin Zhang ◽

Tingting Huang ◽

Yuhang Zhou ◽

Alfred S. L. Cheng ◽

Jun Yu ◽

...

Keyword(s):

Gastric Carcinoma ◽

Epstein Barr Virus ◽

Barr Virus ◽

Epstein Barr

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Role of p53, apoptosis, and cell proliferation in early stage Epstein-Barr virus positive and negative gastric carcinomas

Journal of Clinical Pathology ◽

10.1136/jcp.2003.015081 ◽

2004 ◽

Vol 57 (12) ◽

pp. 1306-1311 ◽

Cited By ~ 9

Author(s):

H H Ishii

Keyword(s):

Cell Proliferation ◽

Epstein Barr Virus ◽

Early Stage ◽

Gastric Carcinomas ◽

Barr Virus ◽

Epstein Barr

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Prevalence of Gastric Cancer Associated with the Epstein-Barr Virus at Brazzaville Chu

International Journal of Health Sciences and Research ◽

10.52403/ijhsr.20210921 ◽

2021 ◽

Vol 11 (9) ◽

pp. 137-141

Author(s):

Fidele Mambouene ◽

Anicet Boumba ◽

Fabien Mouamba

Keyword(s):

Gastric Cancer ◽

Gastric Carcinoma ◽

Key Words ◽

Infection Rate ◽

Epstein Barr Virus ◽

Gastric Carcinomas ◽

Barr Virus ◽

Ebv Infection ◽

Preliminary Study ◽

Epstein Barr

Introduction: Several studies have shown an association between infection with Epstein-Barr virus (EBV) and the occurrence of many cancers in humans, including certain gastric carcinomas (GC). Indeed, recent studies have reported that 10% of CGs are associated with EBV. Materials and Methods: Samples of gastric carcinomatous tissues (biopsies and surgical specimens) were analyzed by PCR for the detection of EBV. Samples were collected retrospectively between January 2008 and December 2018. Results: during this period, 52 samples were analyzed. PCR results show the EBV infection rate to be 3.8%. Conclusion: The results obtained during this preliminary study confirm the association of EBV in 3.8% of CG cases, which is consistent with the data in the literature. Key words: EBV, gastric carcinoma, PCR.

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