scholarly journals Association between common genetic variants in pre-microRNAs and the clinicopathological characteristics and survival of gastric cancer patients

2010 ◽  
Vol 1 (6) ◽  
pp. 1035-1040 ◽  
Author(s):  
MASAAKI OKUBO ◽  
TOMOMITSU TAHARA ◽  
TOMOYUKI SHIBATA ◽  
HIROMI YAMASHITA ◽  
MASAKATSU NAKAMURA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Genetic Variants ◽  
Clinicopathological Characteristics ◽  
Common Genetic Variants ◽  
Gastric Cancer Patients

Genetic variants in miRNA machinery genes associated with clinicopathological characteristics and outcomes of gastric cancer patients

2018 ◽  
Vol 33 (3) ◽  
pp. 301-307 ◽  
Author(s):  
Yuqian Liao ◽  
Yulu Liao ◽  
Jun Li ◽  
Liyan Liu ◽  
Junyu Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Genetic Variants ◽  
Sex Differentiation ◽  
Disease Free Survival ◽  
Clinicopathological Characteristics ◽  
Lymph Node Status ◽  
T Stage ◽  
Poorly Differentiated ◽  
Gastric Cancer Patients

Background: Polymorphisms in miRNA machinery genes have been proved to be related to risk or survival of several kinds of cancers, but the results are controversial and the role of these polymorphisms in gastric cancer remains uncertain. In our study, we investigated the association between five genetic variants in miRNA machinery genes ( DICER, RAN, XPO5 [name of the gene]) and clinical outcomes in Chinese gastric cancer patients. Methods: A total of 96 patients with stage IB-III gastric cancer treated with radical gastrectomy and adjuvant chemotherapy of oxaliplatin and fluorouracils were analyzed. The MassARRAY MALDI-TOF system was used to determine the genotypes. Results: DICER rs3742330 AG+GG genotype was associated with more advanced T stage compared to AA genotype ( P=0.009). More patients with XPO5 rs2257082 CC genotype had poorly differentiated tumors compared with CT+TT genotype carriers. After adjustment by age, sex, differentiation, T stage, and lymph node status, XPO5 rs2257082 CC genotype carriers were found to have worse disease-free survival than CT+TT genotype carriers (adjusted HR 3.099; 95% CI 1.270, 7.564; P=0.013), carriers of RAN rs14035 CC genotype had higher three-year OS rate than carriers of CT+TT genotype (adjusted HR 3.174; 95% CI 1.010, 9.973; P=0.048). Conclusions: These results indicated that genetic variants in miRNA machinery genes might be associated with the clinicopathological features and prognosis of completely resected gastric cancer patients.

scholarly journals Correlations of Human Epithelial Growth Factor Receptor 2 Overexpression with MUC2, MUC5AC, MUC6, p53, and Clinicopathological Characteristics in Gastric Cancer Patients with Curative Resection

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Kwang Kuk Park ◽  
Song I Yang ◽  
Kyung Won Seo ◽  
Ki Young Yoon ◽  
Sang Ho Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Growth Factor Receptor ◽  
Clinicopathological Characteristics ◽  
Her2 Overexpression ◽  
Her2 Expression ◽  
Her2 Positive ◽  
Poor Prognostic Factor ◽  
P53 Expression ◽  
Gastric Cancer Patients

Background. The purpose of this study was to evaluate the relationships between HER2 overexpression in the tumor and MUC2, MUC5AC, MUC6, and p53 status and clinicopathological characteristics of gastric cancer patients.Methods. This retrospective study included 282 consecutive patients with gastric cancer who underwent surgery at the Kosin University Gospel Hospital between April 2011 and December 2012. All tumor samples were examined for HER2 expression by immunohistochemistry (IHC) and MUC2, MUC5AC, MUC6, and p53 expression by staining. A retrospective review of the medical records was conducted to determine the correlation between the presence of HER2 overexpression and clinicopathological factors.Results. The HER2-positive rate was 18.1%. Although no association was found between HER2 expression and MUC5AC, the expression of MUC2, MUC6, and p53 was significantly correlated with HER2 positivity, respectively (P= 0.004, 0.037, 0.002). Multivariate analysis revealed that HER2 overexpression and nodal status were independent prognostic factors.Conclusions. HER2 overexpression in gastric carcinoma is an independent poor prognostic factor.

scholarly journals Study on the Relationship between Expression of LGR5 and Clinicopathological Characteristics in Gastric Cancer Patients

Health ◽  
2018 ◽  
Vol 10 (01) ◽  
pp. 159-169
Author(s):  
Xiulian Xu ◽  
Qijun Lv ◽  
Ping Xie ◽  
Shoujiang Wei ◽  
Chongshu Wang
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Clinicopathological Characteristics ◽  
Gastric Cancer Patients ◽  
The Relationship

scholarly journals Analysis of Clinicopathological Features and Risk Factors for Severe Complications after Gastrectomy for Gastric Cancer in Elderly Patients

2021 ◽  
Vol 27 (2) ◽  
pp. 75-80
Author(s):  
Feng Zhao ◽  
In Cho
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Elderly Patients ◽  
Cancer Patients ◽  
Total Gastrectomy ◽  
Extent Of Resection ◽  
Clinicopathological Characteristics ◽  
Clinicopathological Features ◽  
Elderly Group ◽  
Gastric Cancer Patients

Objective: As life expectancy is increasing, the number and proportion of elderly patients with gastric cancer are also expanded. This study aimed to investigate the clinicopathological features for elderly gastric cancer patients undergoing gastrectomy and analyze risk factors for developing severe complications.Methods: A total of 514 patients treated surgically for gastric cancer between January 2016 and December 2019 were enrolled in this retrospective study. Patients were divided into two groups: younger group ( ≤ 69 years) and elderly group ( ≥ 70 years). Clinicopathological characteristics and operative outcomes including the complications and mortality were compared between two groups. Risk factors for severe complications in elderly gastric cancer patients were also investigated.Results: Of the 514 patients, 145 (28.2%) were elderly group. Comorbidity (P < 0.001), differentiated histology (P = -0.006), deeper in tumor depth (P = 0.012), and frequent lymph node metastasis (P = 0.028) were observed in elderly group. Overall complications (P = 0.046) and severe complications (P = 0.049) were significantly higher in elderly group. Multivariate analysis indicated that extent of resection (P = 0.044) was associated with severe complications in elderly gastric cancer patients.Conclusion: Elderly patients have a significantly higher probability of complications and severe complications than younger patients after gastrectomy for gastric cancer. Especially, when total gastrectomy was performed in elderly gastric cancer patients, the risk of developing serious complications was significantly higher more than 3 times. Therefore, surgeons should pay attention to gastric cancer patients over the age of 70 who require total gastrectomy.

T2064 Clinicopathological Characteristics and Prognosis of Young Age Gastric Cancer : Analysis of 3,362 Consecutive Gastric Cancer Patients

2008 ◽  
Vol 134 (4) ◽  
pp. A-611
Author(s):  
Jun chul Park ◽  
Yong Chan Lee ◽  
Jie-Hyun Kim ◽  
Kyung Ho Song ◽  
Jae Jun Park ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Clinicopathological Characteristics ◽  
Young Age ◽  
Gastric Cancer Patients

scholarly journals High Expression of NLRC5 is associated with prognosis of gastric cancer

Open Medicine ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. 443-449 ◽  
Author(s):  
Yuemei Li ◽  
Min Zhang ◽  
Xinhua Zheng
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Cox Regression ◽  
Clinicopathological Characteristics ◽  
Tnm Staging ◽  
Tumor Node Metastasis ◽  
Node Metastasis ◽  
Gastric Cancer Patients ◽  
The Relationship ◽  
Positive Groups

AbstractObjectiveTo explore the relationships of NLRC5 with clinicopathological characteristics and prognosis of gastric cancer patients.MethodsA total of 97 gastric cancer patients undergoing radical gastrectomy were enrolled. All patients were diagnosed by immunohistochemical staining. The relationship between NLRC5 expression and clinicopatho-logical characteristics of gastric cancer was analyzed via univariate and multivariate Cox regressions.ResultsNLRC5 expression was positive in 70 cases (72.2%) and negative in 27 cases (27.8%). No significant differences in age, sex, or tumor size or differentiation were found between the negative and positive groups. NLRC5 expression was related to tumor site, and in the positive group, it was high in the fundus and low in the pylorus (χ2=7.359, P=0.125). NLRC5 expression was significantly related to lymph nodes and tumor node metastasis (TNM) staging (χ2=6.295; χ2=6.268). Multivariate Cox regression indicated positive NLRC5 expression was independently and significantly associated with prognosis of gastric cancer patients (HR=2.92, 95%CI: 1.51-5.63).ConclusionsNLRC5 is closely related to TNM staging and lymph node metastasis of gastric cancer and is an independent risk factor for the prognosis of gastric cancer patients.

scholarly journals The clinicopathological characteristics and prognosis of node-positive gastric cancer patients after curative surgery

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Chih Yean Lum ◽  
Kuo-Hung Huang ◽  
Ming-Huang Chen ◽  
Wen-Liang Fang ◽  
Yee Chao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Clinicopathological Characteristics ◽  
Curative Surgery ◽  
Node Positive ◽  
Gastric Cancer Patients
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