Clinical significance of CEA-mRNA expression in peritoneal lavage fluid from patients with gastric cancer

2003 ◽  
Author(s):  
Koki Tokuda ◽  
Shoji Natsugoe ◽  
Akihiro Nakajo ◽  
Futoshi Miyazono ◽  
Sumiya Ishigami ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mrna Expression ◽  
Clinical Significance ◽  
Peritoneal Lavage ◽  
Lavage Fluid ◽  
Peritoneal Lavage Fluid ◽  
Cea Mrna

scholarly journals Personalized analysis of minimal residual cancer cells in peritoneal lavage fluid predicts peritoneal dissemination of gastric cancer

2021 ◽  
Author(s):  
Dongbin Zhao ◽  
Pinli Yue ◽  
Tongbo Wang ◽  
Pei Wang ◽  
Qianqian Song ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Cancer Cells ◽  
Peritoneal Lavage ◽  
Peritoneal Dissemination ◽  
Lavage Fluid ◽  
Residual Cancer ◽  
Peritoneal Lavage Fluid ◽  
Minimal Residual Cancer ◽  
Minimal Residual

Abstract Peritoneal dissemination (PD) is the major type of gastric cancer (GC) recurrence and leads to rapid death. Current approach cannot precisely determine which patients are at high risk of PD. In this study, we developed a technology to detect minimal residual cancer cells in peritoneal lavage fluid (PLF) samples by parallel profiling tumor-specific mutations. We applied the technology to a prospective cohort of 110 GC patients. The technology showed ultra-high sensitivity by successfully detecting all the 27 cases that developed PD. The minimal residual cancer cells in PLF was associated with an increased risk of PD (HR = 145.13; 95%CI = 20.20-18435.79; p < 0.001) and significantly shorter overall survival. In pathologically high-risk (T4) patients, the PLF mutation profiling model exhibited even greater specificity of 91% and positive predictive value of 88%, while retaining sensitivity of 100%. PLF cancer cell fraction remained the strongest independent predictor of PD and recurrence-free survival over pathologic diagnosis and cytological diagnosis in GC patients. This approach may help in the postsurgical management of GC patients by detecting PD far before the metastatic lesions grow to significant size detectable by conventional methods such as MRI and CT scanning.

Prognostic Value of CEA and CK20 mRNA in the Peritoneal Lavage Fluid of Patients Undergoing Curative Surgery for Gastric Cancer

2013 ◽  
Vol 38 (5) ◽  
pp. 1107-1111 ◽  
Author(s):  
Akihiro Takata ◽  
Yukinori Kurokawa ◽  
Yoshiyuki Fujiwara ◽  
Yurika Nakamura ◽  
Tsuyoshi Takahashi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Value ◽  
Peritoneal Lavage ◽  
Lavage Fluid ◽  
Curative Surgery ◽  
Peritoneal Lavage Fluid

scholarly journals Personalized analysis of minimal residual cancer cells in peritoneal lavage fluid predicts peritoneal dissemination of gastric cancer

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Dongbing Zhao ◽  
Pinli Yue ◽  
Tongbo Wang ◽  
Pei Wang ◽  
Qianqian Song ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Cancer Cells ◽  
Peritoneal Lavage ◽  
Peritoneal Dissemination ◽  
Lavage Fluid ◽  
Residual Cancer ◽  
Peritoneal Lavage Fluid ◽  
Minimal Residual Cancer ◽  
Minimal Residual

AbstractPeritoneal dissemination (PD) is a major type of gastric cancer (GC) recurrence and leads to rapid death. Current approaches cannot precisely determine which patients are at high risk of PD to provide early intervention. In this study, we developed a technology to detect minimal residual cancer cells in peritoneal lavage fluid (PLF) samples with a personalized assay profiling tumor-specific mutations. In a prospective cohort of 104 GC patients, the technology detected all the cases that developed PD with 100% sensitivity and 85% specificity. The minimal residual cancer cells in PLF were associated with a significantly increased risk of PD (HR = 145.13; 95% CI 20.20–18,435.79; p < 0.001), which was the strongest independent predictor over pathologic diagnosis and cytological diagnosis. In pathologically high-risk (pT4) patients, the PLF mutation profiling model exhibited a greater specificity of 91% and a positive predictive value of 88% while retaining a sensitivity of 100%. This approach may help in the postsurgical management of GC patients by detecting PD far before metastatic lesions grow to a significant size detectable by conventional methods such as MRI and CT scanning.

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