scholarly journals Potent growth-inhibitory effect of a dual cancer-specific oncolytic adenovirus expressing apoptin on prostate carcinoma

2013 ◽  
Vol 42 (3) ◽  
pp. 1052-1060 ◽  
Author(s):  
MUCHUN ZHANG ◽  
JINHUI WANG ◽  
CHANG LI ◽  
NINGNING HU ◽  
KAI WANG ◽  
...  
Keyword(s):  
Prostate Carcinoma ◽  
Inhibitory Effect ◽  
Oncolytic Adenovirus ◽  
Growth Inhibitory Effect ◽  
Growth Inhibitory ◽  
Potent Growth

scholarly journals Erratum to: Potent growth-inhibitory effect of TRAIL therapy mediated by double-regulated oncolytic adenovirus on osteosarcoma

2012 ◽  
Vol 366 (1-2) ◽  
pp. 363-363
Author(s):  
Chunbao Li ◽  
Qianpeng Cheng ◽  
Jia Liu ◽  
Bin Wang ◽  
Dongfeng Chen ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Oncolytic Adenovirus ◽  
Growth Inhibitory Effect ◽  
Growth Inhibitory ◽  
Potent Growth

Potent growth-inhibitory effect of TRAIL therapy mediated by double-regulated oncolytic adenovirus on osteosarcoma

2012 ◽  
Vol 364 (1-2) ◽  
pp. 337-344 ◽  
Author(s):  
Li Chunbao ◽  
Cheng Qianpeng ◽  
Liu Jia ◽  
Wang Bin ◽  
Chen Dongfeng ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Oncolytic Adenovirus ◽  
Growth Inhibitory Effect ◽  
Growth Inhibitory ◽  
Potent Growth

scholarly journals Norhierridin B, a New Hierridin B-Based Hydroquinone with Improved Antiproliferative Activity

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1578
Author(s):  
Pedro Brandão ◽  
Joana Moreira ◽  
Joana Almeida ◽  
Nair Nazareth ◽  
Ivo E. Sampaio-Dias ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Cell Lines ◽  
Human Tumor ◽  
Colon Adenocarcinoma ◽  
Inhibitory Effect ◽  
Growth Inhibitory Effect ◽  
Protein Levels ◽  
Cycle Arrest ◽  
Growth Inhibitory ◽  
Potent Growth

Hierridin B (6), a methylated hydroquinone isolated from the marine picocyanobacterium Cyanobium sp. LEGE 06113, moderately inhibited the growth of colon adenocarcinoma HT-29 cells. Aiming to improve the potential antitumor activity of this natural product, the demethylated analogue, norhierridin B (10), as well as its structurally-related quinone (9), were synthesized and evaluated for their growth inhibitory effect on a panel of human tumor cell lines, including the triple-negative breast cancer (TNBC) cells MDA-MB-231, SKBR3, and MDA-MB-468. Norhierridin B (10) showed a potent growth inhibitory effect on all cancer cell lines. Moreover, the growth inhibitory effect of compound 10 on MDA-MB-231 cells was associated with cell cycle arrest and apoptosis. Norhierridin B (10) interfered with several p53 transcriptional targets, increasing p21, Bax, and MDM2, while decreasing Bcl-2 protein levels, which suggested the potential activation of a p53 pathway. Altogether, these results evidenced a great improvement of the antitumor activity of hydroquinone 10 when compared to 6 and its structurally-related quinone (9). Notably, hydroquinone 10 displayed a prominent growth inhibitory activity against TNBC cells, which are characterized by high therapeutic resistance.

Reduction of linoleic acid inhibition in production of conjugated linoleic acid byPropionibacterium freudenreichiissp.shermanii

2001 ◽  
Vol 47 (8) ◽  
pp. 735-740 ◽  
Author(s):  
A Rainio ◽  
M Vahvaselkä ◽  
T Suomalainen ◽  
S Laakso
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Inhibitory Effect ◽  
Propionibacterium Freudenreichii ◽  
Growth Inhibitory Effect ◽  
Sorbitan Monooleate ◽  
Whey Permeate ◽  
Growth Inhibitory ◽  
De Man ◽  
Sufficient Concentration

A method for the production of conjugated linoleic acid (CLA) from linoleic acid (LA) using growing cultures of Propionibacterium freudenreichii ssp. shermanii JS was developed. The growth inhibitory effect of LA was eliminated by dispersing it in a sufficient concentration of polyoxyethylene sorbitan monooleate detergent. For the whey permeate medium used, the optimum LA:detergent ratio was 1:15 (w/w). As a result, the cultures tolerated at least 1000 µg·mL–1LA, which was converted to CLA with 57%–87% efficiency. The cis-9, trans-11 and trans-9, cis-11 isomers constituted 85%–90% of the CLA produced. The feasibility of the method was demonstrated also in de Man – Rogosa–Sharpe (MRS) broth.Key words: conjugated linoleic acid, linoleic acid, Propionibacterium freudenreichii ssp. shermanii.

Type II oestrogen binding sites in acute lymphoid and myeloid leukaemias: growth inhibitory effect of oestrogen and flavonoids

1990 ◽  
Vol 75 (4) ◽  
pp. 489-495 ◽  
Author(s):  
L. M. Larocca ◽  
M. Piantelli ◽  
G. Leone ◽  
S. Sica ◽  
L. Teofili ◽  
...  
Keyword(s):  
Binding Sites ◽  
Inhibitory Effect ◽  
Type Ii ◽  
Growth Inhibitory Effect ◽  
Growth Inhibitory

Growth inhibitory effect of bestatin on choriocarcinoma cell finesin vitro

Biotherapy ◽  
1991 ◽  
Vol 3 (4) ◽  
pp. 351-357 ◽  
Author(s):  
Kazuhiko Ino ◽  
Setsuko Goto ◽  
Akemi Kosaki ◽  
Seiji Nomura ◽  
Eiko Asada ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Growth Inhibitory Effect ◽  
Growth Inhibitory
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