scholarly journals SENP2 exerts an anti‑tumor effect on chronic lymphocytic leukemia cells through the inhibition of the Notch and NF‑κB signaling pathways

2018 ◽  
Author(s):  
Xiu‑Li Chen ◽  
Shi‑Fen Wang ◽  
Xue‑Ting Liang ◽  
Hui‑Xin Liang ◽  
Ting‑Ting Wang ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Signaling Pathways ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells

scholarly journals Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts

Blood ◽  
2015 ◽  
Vol 126 (9) ◽  
pp. 1106-1117 ◽  
Author(s):  
Jerome Paggetti ◽  
Franziska Haderk ◽  
Martina Seiffert ◽  
Bassam Janji ◽  
Ute Distler ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Cell Survival ◽  
Signaling Pathways ◽  
Stromal Cells ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Cancer Associated Fibroblasts ◽  
Key Points

Key Points CLL-derived exosomes are internalized by stromal cells, deliver functional microRNA and proteins, and activate key signaling pathways. Stromal cells exposed to CLL-derived exosomes demonstrate a CAF-like phenotype and secrete factors promoting CLL cell survival.

scholarly journals Targeting DNA Repair in Chronic Lymphocytic Leukemia Cells with a Novel Acyclic Nucleotide Analogue, GS-9219

2009 ◽  
Vol 15 (11) ◽  
pp. 3760-3769 ◽  
Author(s):  
Cheng-Yu Tsai ◽  
Adrian S. Ray ◽  
Daniel B. Tumas ◽  
Michael J. Keating ◽  
Hans Reiser ◽  
...  
Keyword(s):  
Dna Repair ◽  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Nucleotide Analogue

scholarly journals Induction of histone H1.2 cytosolic release in chronic lymphocytic leukemia cells after genotoxic and non-genotoxic treatment

Haematologica ◽  
2008 ◽  
Vol 93 (1) ◽  
pp. 75-82 ◽  
Author(s):  
E. Gine ◽  
M. Crespo ◽  
A. Muntanola ◽  
E. Calpe ◽  
M. J. Baptista ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells
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