scholarly journals Intraoperative prediction of non‑sentinel lymph node metastases in breast cancer using cytokeratin 19 mRNA copy number: A retrospective analysis

2022 ◽  
Vol 16 (3) ◽  
Author(s):  
Heloïse Pina ◽  
Julia Salleron ◽  
Pauline Gilson ◽  
Marie Husson ◽  
Marie Rouyer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Retrospective Analysis ◽  
Lymph Node Metastases ◽  
Copy Number ◽  
Cytokeratin 19 ◽  
Mrna Copy Number ◽  
Node Metastases

P011 A new clinical cut-off of cytokeratin 19 mRNA copy number in sentinel lymph node of breast cancer

The Breast ◽  
2015 ◽  
Vol 24 ◽  
pp. S29
Author(s):  
S. Buglioni ◽  
I. Terrenato ◽  
B. Casini ◽  
V. D'Alicandro ◽  
F. Di Filippo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Copy Number ◽  
Cytokeratin 19 ◽  
Mrna Copy Number

329 Validation of the MSKCC nomogram to predict sentinel lymph node metastases in a Dutch breast cancer population

2010 ◽  
Vol 8 (3) ◽  
pp. 153-154
Author(s):  
R. van la Parra ◽  
C. Francissen ◽  
P.G. Peer ◽  
M.F. Ernst ◽  
D. Mulder ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastases ◽  
Mskcc Nomogram ◽  
Node Metastases

scholarly journals Simultaneous Foxp3 and IDO expression is associated with sentinel lymph node metastases in breast cancer

BMC Cancer ◽  
2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Aaron S Mansfield ◽  
Paivi S Heikkila ◽  
Ari T Vaara ◽  
Karl AJ von Smitten ◽  
Jukka M Vakkila ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastases ◽  
Node Metastases

scholarly journals Non-Sentinel Lymph Node Metastases Associated With Isolated Breast Cancer Cells in the Sentinel Node

2008 ◽  
Vol 100 (22) ◽  
pp. 1574-1580 ◽  
Author(s):  
C. H. M. van Deurzen ◽  
M. de Boer ◽  
E. M. Monninkhof ◽  
P. Bult ◽  
E. van der Wall ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Node ◽  
Cancer Cells ◽  
Lymph Node Metastases ◽  
Breast Cancer Cells ◽  
Node Metastases

Usefulness of touch imprint cytology with immunocytochemistry of sentinel lymph node metastases in breast cancer

2014 ◽  
Vol 53 (4) ◽  
pp. 280-285
Author(s):  
Kiyofumi UEDA ◽  
Kanako MORI ◽  
Ayaka KOBAYASHI ◽  
Yuko TESHIMA ◽  
Chikoto DOBASHI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastases ◽  
Imprint Cytology ◽  
Touch Imprint Cytology ◽  
Node Metastases

Intraoperative imprint cytology for the detection of sentinel lymph node metastases in breast cancer

2007 ◽  
Vol 46 (4) ◽  
pp. 203-210 ◽  
Author(s):  
Sachiko NAGUMO ◽  
Tatsuki KATAOKA ◽  
Jyunichi ASHIMURA ◽  
Akemi TAKENAKA ◽  
Yasuyoshi NARUSE ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastases ◽  
Imprint Cytology ◽  
Node Metastases

The use of one-step nucleic acid amplification (OSNA) and tumor-related factors in the axillary management of breast cancer: A predictive model.

2015 ◽  
Vol 33 (28_suppl) ◽  
pp. 61-61
Author(s):  
Shramana Mitul Banerjee ◽  
Norman R. Williams ◽  
Timothy Ian Davidson ◽  
Soha El-Sheikh ◽  
My-annh Tran-Dang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Nucleic Acid ◽  
Sentinel Lymph Node ◽  
Copy Number ◽  
Nucleic Acid Amplification ◽  
Nodal Involvement ◽  
Related Factors ◽  
One Step ◽  
Node Metastases

61 Background: Recent trends in surgical practice advocate selective use of axillary nodal clearance (ANC) following sentinel lymph node biopsy (SNB) in the treatment of breast cancer. We aimed to determine the effectiveness of one-step nucleic acid amplification (OSNA) using CK19 mRNA copy number and tumor-related factors in predicting non-sentinel axillary nodal involvement, in order to formulate local guidelines for ANC. Methods: Patients due to have SNB at our institution for invasive breast cancer as well as selected patients with high grade ductal carcinoma in situ with negative assessment of the axilla on pre-operative imaging were included. Alternate slices of each node were sent for assessment by either OSNA or Histopathology. Immediate ANC was performed if OSNA was positive. The CK19 mRNA copy number, the total tumor load (summation of m RNA copy number of positive nodes,TTL), the total nodal status at ANC and tumor characteristics including grade, tumor size and lymphovascular invasion (LVI) for each patient were determined. A model of risk probability was constructed using TTL and tumor related factors. Results: 664 nodes were examined from 425 patients who had SNB performed between 2011 and 2014. After excluding 8 patients who did not meet the study criteria, 648 nodes from 417 patients were included for analysis. The concordance between OSNA and histology was 91.4%; positive predictive value (PPV) and negative predictive value (NPV) was 77% and 97% respectively. Patients with TTL less than 1400 did not have additional non sentinel lymph node involvement. TTL (p<0.01), and presence of LVI (p<0.05) were predictive for additional nodal involvement. The risk model identified all patients with more than 2 positive nodes as requiring ANC. All patients with non-sentinel node metastases at ANC were selected. Conclusions: OSNA is a sensitive and reliable intraoperative method for the detection of sentinel node metastases. Our study has shown it can also be used to predict the presence of non-sentinel metastases. Patients deemed high risk may be offered immediate ANC while axillary surgery in other groups may be omitted or be decision-based on risk stratification.

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