scholarly journals Role of extracellular signal-regulated kinase 1/2 signal transduction pathway in insulin secretion by β-TC6 cells

2016 ◽  
Vol 13 (5) ◽  
pp. 4451-4454 ◽  
Author(s):  
BEN NIU ◽  
LIJUAN LIU ◽  
HENG SU ◽  
XUESHAN XIA ◽  
QIU HE ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Insulin Secretion ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

Signal transduction pathway and physiological role of endothelin in the kidney

1994 ◽  
Vol 1 ◽  
pp. 80
Author(s):  
K. Tomita ◽  
A. Owada ◽  
H. Nonoguchi ◽  
Y. Terada ◽  
F. Marumo
Keyword(s):  
Signal Transduction ◽  
Signal Transduction Pathway ◽  
Physiological Role ◽  
Transduction Pathway

III. Role of the RET signal transduction pathway in development of the mammalian enteric nervous system

1998 ◽  
Vol 275 (2) ◽  
pp. G183-G186 ◽  
Author(s):  
V. Pachnis ◽  
P. Durbec ◽  
S. Taraviras ◽  
M. Grigoriou ◽  
D. Natarajan
Keyword(s):  
Signal Transduction ◽  
Nervous System ◽  
Enteric Nervous System ◽  
Signal Transduction Pathway ◽  
Multiple Roles ◽  
Tyrosine Kinase Receptor ◽  
Transduction Pathway ◽  
Complex Part ◽  
Induced Mutagenesis

The enteric nervous system (ENS) in vertebrates is derived from the neural crest and constitutes the most complex part of the peripheral nervous system. Natural and induced mutagenesis in mammals has shown that the tyrosine kinase receptor RET and its functional ligand glial cell line-derived neurotrophic factor (GDNF) play key roles in the development of the ENS in humans and mice. We have developed and briefly describe here a number of assays that analyze the specific function of the RET receptor and its ligand. Our data suggest that the RET signal transduction pathway has multiple roles in the development of the mammalian ENS.

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