scholarly journals Chemokine (C-C motif) ligand 21/C-C chemokine receptor type 7 triggers migration and invasion of human lung cancer cells by epithelial-mesenchymal transition via the extracellular signal-regulated kinase signaling pathway

2017 ◽  
Vol 15 (6) ◽  
pp. 4100-4108 ◽  
Author(s):  
Guangxin Zhong ◽  
Lu Chen ◽  
Ruihong Yin ◽  
Yan Qu ◽  
Yongxing Bao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Human Lung ◽  
Epithelial Mesenchymal Transition ◽  
Human Lung Cancer ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Human Lung Cancer Cells ◽  
Kinase Signaling Pathway

scholarly journals Cancer upregulated gene 2 induces epithelial-mesenchymal transition of human lung cancer cells via TGF-β signaling

Oncotarget ◽  
2016 ◽  
Vol 8 (3) ◽  
pp. 5092-5110 ◽  
Author(s):  
Sirichat Kaowinn ◽  
Jeonghyo Kim ◽  
Jaebeom Lee ◽  
Dong Hoon Shin ◽  
Chi-Dug Kang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Epithelial Mesenchymal Transition ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Mesenchymal Transition ◽  
Human Lung Cancer Cells

scholarly journals Chemical Investigation of Diketopiperazines and N-Phenethylacetamide Isolated from Aquimarina sp. MC085 and Their Effect on TGF-β-Induced Epithelial–Mesenchymal Transition

2021 ◽  
Vol 11 (19) ◽  
pp. 8866
Author(s):  
Myong Jin Lee ◽  
Geum Jin Kim ◽  
Myoung-Sook Shin ◽  
Jimin Moon ◽  
Sungjin Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Spectroscopic Data ◽  
Human Lung ◽  
Epithelial Mesenchymal Transition ◽  
A549 Cells ◽  
Human Lung Cancer ◽  
Smad Pathway ◽  
Mesenchymal Transition ◽  
Data Analyses ◽  
Human Lung Cancer Cells

Chemical investigations of Aquimarina sp. MC085, which suppressed TGF-β-induced epithelial–mesenchymal transition (EMT) in A549 human lung cancer cells, led to the isolation of compounds 1–3. Structural characterization using spectroscopic data analyses in combination with Marfey’s analysis revealed that they were two diketopiperazines [cyclo(l-Pro-l-Leu) (1) and cyclo(l-Pro-l-Ile) (2)] and one N-phenethylacetamide (3). Cyclo(l-Pro-l-Leu) (1) and N-phenethylactamide (3) inhibited the TGF-β/Smad pathway and suppressed the metastasis of A549 cells by affecting TGF-β-induced EMT. However, cyclo(l-Pro-l-Ile) (2) downregulated mesenchymal factors via a non-Smad-mediated signaling pathway.

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