Expression and prognostic significance of TAp73 and ΔNp73 in FIGO stage I-II cervical squamous cell carcinoma

Abstract Background We investigated the expression and clinical significance of miR-141 and miR-340 in cervical squamous cell carcinoma (CSCC). Methods Expression of miR-141 and miR-340 in CSCC, high-grade squamous intraepithelial lesion (HSIL), and normal cervical squamous epithelium were detected by qRT-PCR. PTEN was assessed by immunohistochemistry. Their relationship with clinicopathological features was analyzed. Results The changes of miR-141 and miR-340 were different in CSCC, HSIL, and normal squamous epithelium (P = 0.030). miR-141 expression was statistically significant in gross type, differentiation, uterine corpus invasion, nerve invasion, vagina invasion, and FIGO stage in CSCC (P < 0.05). miR-340 expression was related to tumor size, differentiation, nerve invasion, lymph node metastasis, and FIGO stage in CSCC (P < 0.05). miR-141 and miR-340 expressions were statistically significant in different ages (P < 0.05) in HSIL. The AUC of miR-141 in CSCC diagnosis and that of miR-340 in HSIL diagnosis were 0.893 and 0.764, respectively. The sensitivity and the specificity of miR-141 for diagnosis of CSCC were 95.0% and 60.8%, respectively, while those of miR-340 for diagnosis of HSIL were 90.0 and 48.6%, respectively. miR-141 and miR-340 expressions are associated with PTEN expression (P = 0.002 and P < 0.001). Conclusion miR-141 and miR-340 may be associated with their target gene PTEN and involved in the carcinogenesis of cervical squamous epithelium.

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Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma

Virchows Archiv ◽

10.1007/s00428-007-0535-z ◽

2007 ◽

Vol 452 (1) ◽

pp. 65-74 ◽

Cited By ~ 9

Author(s):

Enrique Lerma ◽

Marisa Romero ◽

Alberto Gallardo ◽

Cristina Pons ◽

Josefina Muñoz ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Fas Ligand ◽

Prognostic Significance ◽

Cervical Squamous Cell Carcinoma ◽

Fas Receptor ◽

Ligand System

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P53 expression as a predictor of recurrence in cervical squamous cell carcinoma

International Journal of Gynecological Cancer ◽

10.1136/ijgc-00009577-200205000-00010 ◽

2002 ◽

Vol 12 (3) ◽

pp. 299-303 ◽

Cited By ~ 1

Author(s):

S. M. F Brenna ◽

L. C Zeferino ◽

G. A Pinto ◽

R. A Souza ◽

L. A. L Andrade ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Protein Expression ◽

Cell Carcinoma ◽

Squamous Cell ◽

P53 Protein ◽

Figo Stage ◽

Cervical Squamous Cell Carcinoma ◽

Stage Ii ◽

P53 Expression ◽

P53 Protein Expression

Abstract.Brenna SMF, Zeferino LC, Pinto GA, Souza RA, Andrade LAL, Vassalo J, Martinez EZ, Syrjänen KJ. P53 expression as a predictor of recurrence in cervical squamous cell carcinoma.P53 protein function is frequently down-regulated in cervical cancer by complexing with human papillomavirus (HPV) E6 protein, leading to degradation of p53, genomic instability, and mutations. Results are controversial, however, on the prognostic value of p53 protein expression in cervical cancer. In this study, a cohort of 220 Brazilian women with FIGO stage IB-III cervical squamous cell carcinoma (SCC), followed for 5 years, was analyzed for p53 protein expression using immunohistochemistry. The disease-free survival (DFS) and relapse rate were analyzed using univariate (Kaplan-Meier) and multivariable (Cox's proportional hazards model) survival analyses. P53 protein expression was detected in 35% of the patients, including 21% in stage I, 28% in stage II and 51% in stage III of disease. Of 220 women, only 116 completed one of the treatment options standardized by FIGO within 120 days. There was a higher risk of relapse in stage II and III disease, that was not modified by p53 positivity; HR 3.0 (1.3–6.5) to stage II and HR 4.0 (1.9–8.5) to stage III. The multivariate analysis evidenced that p53 expression is not an independent factor exceeding the power of FIGO stage as the single most important determinant of the hazards for disease relapse.

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Prognostic significance of CD24 protein expression in patients treated with adjuvant radiotherapy after radical hysterectomy for cervical squamous cell carcinoma

Radiotherapy and Oncology ◽

10.1016/j.radonc.2010.01.007 ◽

2010 ◽

Vol 95 (3) ◽

pp. 359-364 ◽

Cited By ~ 8

Author(s):

Chang Ohk Sung ◽

Won Park ◽

Yoon-La Choi ◽

Geunghwan Ahn ◽

Sang Yong Song ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Protein Expression ◽

Cell Carcinoma ◽

Squamous Cell ◽

Radical Hysterectomy ◽

Adjuvant Radiotherapy ◽

Prognostic Significance ◽

Cervical Squamous Cell Carcinoma

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Prognostic significance of histone methyltransferase enhancer of zeste homolog 2 in patients with cervical squamous cell carcinoma

Oncology Letters ◽

10.3892/ol.2015.3319 ◽

2015 ◽

Vol 10 (2) ◽

pp. 857-862 ◽

Cited By ~ 8

Author(s):

MINFEI JIN ◽

ZUJING YANG ◽

WEIPING YE ◽

XIAOWEI YU ◽

XIAOLIN HUA

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Prognostic Significance ◽

Cervical Squamous Cell Carcinoma ◽

Histone Methyltransferase ◽

Enhancer Of Zeste

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Evaluation of 2 Commercially Systems for Detection of Serum Squamous Cell Carcinoma Antigen in Pan Squamous Cell Carcinoma

Cancer Control ◽

10.1177/1073274820983025 ◽

2020 ◽

Vol 27 (1) ◽

pp. 107327482098302

Author(s):

Hao Chen ◽

Liru Tian ◽

Jiahong Chen ◽

Peng Sun ◽

Runkun Han ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Bladder Cancer ◽

Cell Carcinoma ◽

Squamous Cell ◽

Lung Squamous Cell Carcinoma ◽

Stage Iv ◽

Cervical Squamous Cell Carcinoma ◽

Stage I ◽

Cancer Stage ◽

Squamous Cell Carcinoma Antigen

Background: This study compared the analytical performance of the Elecsys 602 (Roche Diagnostics) system with the I2000 (Abbott laboratories) system for the quantitative measurement of squamous cell carcinoma antigen (SCCA) to assess its role as an indicator in pan squamous cell carcinoma. Methods: 435 serum samples included pan squamous cell cancer group (n = 318) and healthy subjects (n = 52) and non-squamous cell group (n = 41) and benign diseases group (n = 24) were measured by 2 systems and compared. Results: The within-run precision coefficient of variation (CV) for Abbott and Roche systems were 3.34-4.88% and 0.95 -1.96%, and the total precision CV were 2.89-9.48% and 3.97-5.38%, respectively. Good correlation was showed in Abbott and Roche systems (slopes = 0.749, r = 0.9658). Serum SCCA in the groups of nasopharyngeal carcinomas, lung squamous cell carcinoma, esophageal squamous cell carcinoma, bladder cancer and cervical squamous cell carcinoma under the curve area (AUC) was more than 0.5, while the AUC in the non- nasopharyngeal carcinomas head and neck squamous cell carcinoma was less than 0.5. The AUC of 2 systems was statistically different in lung squamous cell carcinoma and nasopharyngeal carcinomas (P < 0.05). The levels of SCCA of 2 systems were similarities in esophageal squamous cell carcinoma(stage IV vs. stage 0a-II)and bladder cancer(stage I vs. stage Oa)and cervical squamous cell carcinoma(stage IIB-III vs. stage I-IIA), which advanced stage had higher level of SCCA than early stage. But the SCCA levels of 2 systems were inconsistent in bladder cancer (stage II-IV vs. stage Oa in Abbott), head and neck squamous cell carcinoma (stage IV vs. stage Oa-I in the Roche) and lung squamous cell carcinoma (stage III vs. stage I-II in the Roche). (P < 0.05) Conclusions: 2 systems correlated well in SCCA detection of squamous cell carcinoma, but there were individual differences. Serum SCCA may also contribute to the diagnosis of bladder cancer.

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HIF1α and SOX2 expression in cervical squamous cell carcinoma

Vojnosanitetski pregled ◽

10.2298/vsp171213043m ◽

2019 ◽

Vol 76 (12) ◽

pp. 1253-1260

Author(s):

Svetlana Milenkovic ◽

Tatjana Terzic ◽

Boris Vranes ◽

Ivan Soldatovic

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Squamous Cell ◽

Hypoxia Inducible Factor ◽

Prognostic Significance ◽

Tumor Grade ◽

Cervical Squamous Cell Carcinoma ◽

Histopathological Analysis ◽

Significant Difference

Background/Aim. Hypoxia is one of the major changes that occurs in the tumor microenvironment. It has been observed that there are pluripotent cancer cells in the cancer cell population that affect tumor growth and their resistance to therapy. The aim of this study was to examine the expression of hypoxia-inducible factor-1 alpha (HIF-1?), endogenous marker of hypoxia, and SOX2, marker of the pluripotent stem cells existing in the normal adult tissues, in the cervical squamous cell carcinoma (SCC). Methods. The study was conducted in 90 women with invasive cervical SCC, divided into two groups ? 60 women in the Group A, with FIGO IB1 < 20 mm tumors (no metastases in the lymph nodes), and 30 women in the group B with tumors FIGO I?II (positive lymph nodes). The basic clinical parameters were determined by standard histopathological analysis, and the expression of HIF-1? and SOX2 by immunohistochemical examination. Results. There was a significant difference between the groups A and B, in the expression of HIF-1? (p = 0.024), but not in the expression of SOX2 (p = 0.566). Expression of HIF-1? was significantly higher in the group with lymph node metastases and invasion of lymphovascular spaces (p <0.001) but not associated with tumor size (p = 0.291) or lymphocytic stromal response (p = 0.940). The tumor grade significantly influenced the expression of HIF-1? (p = 0.013). The expression of SOX2 did not significantly correlate with any of the established clinical tumor parameters. Conclusion. A significant difference in the expression of HIF-1 ? between the group with and that without metastases in lymph nodes in invasive cervical SCC could distinguish HIF-1? as a parameter of poor prognosis of the disease. The prognostic significance of SOX2 as well as a significant correlation between expression of HIF-1? and SOX2 were not established.

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