scholarly journals MicroRNA‑454‑3p inhibits cell proliferation and invasion in esophageal cancer by targeting insulin‑like growth factor 2 mRNA‑binding protein 1

2020 ◽  
Vol 20 (6) ◽  
pp. 1-1
Author(s):  
Aiting Yan ◽  
Cuizhu Wang ◽  
Liangfeng Zheng ◽  
Jiebo Zhou ◽  
Yan Zhang
Keyword(s):  
Cell Proliferation ◽  
Esophageal Cancer ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Mrna Binding Protein ◽  
Mrna Binding ◽  
Proliferation And Invasion

Insulin-like growth factor 2 mRNA binding protein 2 promotes aerobic glycolysis and cell proliferation in pancreatic ductal adenocarcinoma via stabilizing GLUT1 mRNA

2019 ◽  
Vol 51 (7) ◽  
pp. 743-752 ◽  
Author(s):  
Shan Huang ◽  
Zheng Wu ◽  
Yunyun Cheng ◽  
Wenzhen Wei ◽  
Linlin Hao
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Binding Protein ◽  
Aerobic Glycolysis ◽  
Ductal Adenocarcinoma ◽  
Insulin Like Growth Factor ◽  
Mrna Binding Protein ◽  
Mrna Binding ◽  
Glut1 Mrna

Abstract Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) is a member of the IGF2BP protein family consisting of IGF2BP1~3 with the capacity of binding to many transcripts and regulating RNA stability, localization, and translation. In this study, we discovered that expression of IGF2BP2 was upregulated and led to a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). IGF2BP2 protein was gradually elevated from normal pancreas, pancreatic intraepithelial neoplasia to PDAC in an LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx1-Cre mouse model. Furthermore, we demonstrated that IGF2BP2 promoted aerobic glycolysis and PDAC cell proliferation through directly binding to and stabilizing GLUT1 mRNA. In summary, our study unveiled an important role of IGF2BP2 in PDAC development by modulating aerobic glycolysis and as a potential therapeutic target for PDAC treatment.

scholarly journals Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Xinwei Huang ◽  
Hong Zhang ◽  
Xiaoran Guo ◽  
Zongxin Zhu ◽  
Haibo Cai ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Mrna Binding Protein ◽  
Mrna Binding

The roles of Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3) in melanoma progression

2013 ◽  
Vol 69 (2) ◽  
pp. e20-e21
Author(s):  
Chia-Yu Chu ◽  
Yi-Shuan Sheen ◽  
Kuanyin K. Lin ◽  
Meng-Chen Hsieh ◽  
Hsien-Ching Chiu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Messenger Rna ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Melanoma Progression ◽  
Factor Ii ◽  
Mrna Binding Protein ◽  
Mrna Binding

scholarly journals Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis

2020 ◽  
Vol 10 ◽  
Author(s):  
Caterina Mancarella ◽  
Giulia Caldoni ◽  
Irene Ribolsi ◽  
Alessandro Parra ◽  
Maria Cristina Manara ◽  
...  
Keyword(s):  
Growth Factor ◽  
Ewing Sarcoma ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Mrna Binding Protein ◽  
Mrna Binding ◽  
Cxcr4 Axis
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