scholarly journals Long non‑coding RNA MIAT knockdown potentiates the therapeutic effect of transcatheter arterial embolization in liver cancer by regulating the miR‑203a/HIF‑1α axis

2020 ◽  
Vol 44 (2) ◽  
pp. 722-734
Author(s):  
Jian Liu ◽  
Guangshao Cao ◽  
Jianwen Liu ◽  
Xiaoyang Zhao ◽  
Huicun Cao
Keyword(s):  
Liver Cancer ◽  
Therapeutic Effect ◽  
Transcatheter Arterial Embolization ◽  
Arterial Embolization ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Current advances of long non-coding RNA highly upregulated in liver cancer in human tumors

2017 ◽  
Vol Volume 10 ◽  
pp. 4711-4717 ◽  
Author(s):  
Zhonghua Ma ◽  
Hesuyuan Huang ◽  
Yetao Xu ◽  
Xuezhi He ◽  
Jirong Wang ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Human Tumors ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer

2010 ◽  
Vol 38 (16) ◽  
pp. 5366-5383 ◽  
Author(s):  
Jiayi Wang ◽  
Xiangfan Liu ◽  
Huacheng Wu ◽  
Peihua Ni ◽  
Zhidong Gu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non‑coding RNA BCAR4 promotes liver cancer progression by regulating proliferation, migration and invasion

2020 ◽  
Vol 20 (3) ◽  
pp. 2779-2787
Author(s):  
Aiyao Wang ◽  
Jun Meng ◽  
Hui Liu ◽  
Chen Li ◽  
Zhiyong Zhou
Keyword(s):  
Liver Cancer ◽  
Cancer Progression ◽  
Migration And Invasion ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA HULC affects the proliferation, apoptosis, migration, and invasion of mesenchymal stem cells

2018 ◽  
Vol 243 (13) ◽  
pp. 1074-1082 ◽  
Author(s):  
Xiujun Li ◽  
Jiali Wang ◽  
Yuchen Pan ◽  
Yujun Xu ◽  
Dan Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Cancer ◽  
Clinical Application ◽  
Molecular Mechanisms ◽  
Migration And Invasion ◽  
Therapeutic Effects ◽  
Non Coding Rna ◽  
And Function ◽  
Long Non Coding Rna

Further studies on the molecular mechanisms of mesenchymal stem cells in the maintenance of growth and function are essential for their clinical application. Growing evidence has shown that long non-coding RNAs (lncRNAs) play an important role in the regulation of mesenchymal stem cells. Recently, it is reported that highly upregulated in liver cancer (HULC), with another lncRNA MALAT-1, accelerated liver cancer stem cell growth. The regulating role of MALAT-1 in mesenchymal stem cells has been investigated. However, the effects of HULC on the mesenchymal stem cells are unknown. In this study, we overexpressed HULC in mesenchymal stem cells derived from umbilical cord and analyzed the cell phenotypes, proliferation, apoptosis, migration, invasion and differentiation of mesenchymal stem cells. We found that overexpression of HULC significantly promotes cell proliferation through promoting cell division and inhibits cell apoptosis. HULC-overexpressed mesenchymal stem cells migrate and invade faster than control mesenchymal stem cells. HULC has no effect on phenotypes and differentiation of mesenchymal stem cells. Furthermore, we found that the expression of HULC in mesenchymal stem cells could be reduced by several inflammatory factors, including TNF-α, TGF-β1, and R848. Taken together, our data demonstrated that HULC has a vital role in the growth and function maintenance of mesenchymal stem cells without affecting differentiation. Impact statement Exploring the molecular mechanisms of growth and function in MSCs is the key to improve their clinical therapeutic effects. Currently, more and more evidence show that the long non-coding RNA (lncRNA) plays an important role in the growth, stemness and function of MSCs.Both HULC and MALAT1 are the earliest discovered LNCRNAs, which are closely related to tumor growth. All of them can promote the growth of liver cancer stem cells. Previously, we have studied the effects of MALAT1 on the growth and function of MSCs. In this study, we focused on the effects of HULC on MSCs. We elucidated the effects of HULC on the growth and differentiation of MSCs, and explored the relationship between inflammatory stimuli and HULC expression in MSCs. Our findings provide a new molecular target for the growth and clinical application of MSCs.

scholarly journals Association of lncRNA H19 Gene Polymorphisms with the Occurrence of Hepatocellular Carcinoma

Genes ◽  
2019 ◽  
Vol 10 (7) ◽  
pp. 506 ◽  
Author(s):  
Edie-Rosmin Wu ◽  
Ying-Erh Chou ◽  
Yu-Fan Liu ◽  
Kuan-Chun Hsueh ◽  
Hsiang-Lin Lee ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Gene Polymorphisms ◽  
Primary Liver Cancer ◽  
Common Type ◽  
Cancer Development ◽  
Inhibitory Effects ◽  
Non Coding Rna ◽  
H19 Gene ◽  
Long Non Coding Rna

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, whose diversified occurrence worldwide indicates a connection between genetic variations among individuals and the predisposition to such neoplasms. Mounting evidence has demonstrated that long non-coding RNA (lncRNA) H19 can have both promotive and inhibitory effects on cancer development, revealing a dual role in tumorigenesis. In this study, the link of H19 gene polymorphisms to hepatocarcinogenesis was assessed between 359 HCC patients and 1190 cancer-free subjects. We found that heterozygotes for the minor allele of H19 rs2839698 (T) and rs3741219 (G) were more inclined to develop HCC (OR, 1.291; 95% CI, 1.003–1.661; p = 0.047, and OR, 1.361; 95% CI, 1.054–1.758; p = 0.018, respectively), whereas homozygotes for the polymorphic allele of rs2107425 (TT) were correlated with a decreased risk of HCC (OR, 0.606; 95% CI, 0.410–0.895; p = 0.012). Moreover, patients who bear at least one variant allele (heterozygote or homozygote) of rs3024270 were less prone to develop late-stage tumors (for stage III/IV; OR, 0.566; 95% CI, 0.342–0.937; p = 0.027). In addition, carriers of a particular haplotype of three H19 SNPs tested were more susceptible to HCC. In conclusion, our results indicate an association between H19 gene polymorphisms and the incidence and progression of liver cancer.

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