In order to effectively improve hydraulic performance of centrifugal pump on off-conditions, the hydraulic design of inlet guide vane (IGV) was completed by adopting two dimensional theory in-house code based on one kind of IS series of centrifugal pump, which can achieve pre-whirl regulation of centrifugal pump. During design process the trailing edge of vane is assumed as equal velocity moment condition, and the distribution of vane setting angle along meridional streamline is also given as a quartic function firstly, the camber line is then drawn by point-by-point integration method and thickened at both sides along circumferential direction. With local vortex dynamics diagnosis theory, the optimal improvement of vane space shape can be finished by adjusting the design parameters of vane setting angle distribution coefficient ap. The full flow passage numerical simulations of centrifugal pump with IGV device are completed to analyze the influence of pre-whirl regulation on hydraulic performance of centrifugal pump under various pre-whirl angles. The results show that the pre-whirl regulation can improve the hydraulic performance of centrifugal pump on off-conditions. Under the positive pre-whirl regulation conditions, the best efficient point shift to small flow rate zone, and under the negative pre-whirl regulation conditions it moves to large flow rate zone. Compared with the pump without IGV device at the same flow rate condition of 0.8Q (Q the design flow rate), the hydraulic efficiency of centrifugal pump with IGV device improves obviously and reaches up to 1.43%. Meanwhile compared with that installed with the straight vanes designed based on the traditional theory, the inner flow field of centrifugal pump with the designed vanes improves and the overall hydraulic efficiency of centrifugal pump is somewhat increased.