scholarly journals Possible prediction of patterns of cervical lymph node spread based on primary tumor location in papillary thyroid carcinomas

2019 ◽  
Author(s):  
MEHMET ESER SANCAKTAR ◽  
GÜLESER SAYLAM ◽  
BÜLENT ÖCAL ◽  
AHMET ULUAT ◽  
ÖMER BAYIR ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Location ◽  
Central Neck ◽  
Lateral Neck ◽  
Papillary Thyroid ◽  
Regional Lymph Nodes ◽  
Neck Metastasis ◽  
Thyroid Carcinomas ◽  
Node Metastasis

Backround/aim: Papillary thyroid carcinomas (PTC) frequently metastasize to regional lymph nodes. We purposed to investigate the predictive role of tumor location for lymph node metastasis pattern in PTCs. Materials and methods: Medical records of 110 PTC patients were reviewed retrospectively. Tumor location was determined as upper, middle and lower pole according to ultrasonography (USG) findings. The effects of age, gender, tumor size and location on lymph node metastasis were investigated. Results: The series comprised 87% females (n:96), and 13% males (n:14). 43 patients had central neck metastasis (CNM), 14 had lateral neck metastasis (LNM). Upper pole tumors (UPT) metastasized to the central neck (CN) at a lower rate (17.6%) than middle (40.0%) or lower (48.5%) poles overall (p:0.104), while it was at a significantly lower rate (13.3%) in the PTC group (p<0.05). UPTs (n:17) metastasized to the lateral neck (LN) at almost 2-fold more. It was observed that 3 of 4 UPTs spread directly to the LN without CNM. Conclusion: In our opinion, UPTs have propensity to demonstrate metastase to LN rather than the CN in PTCs. Therefore, UPTs should be evaluated meticulously in terms of LNM. New studies could suggest that CN dissection is not performed for low risk PTCs in UPTs. Key words: Papillary thyroid cancer, lymph node metastase, tumor location

scholarly journals Plasma Exosomal miR-146b-5p and miR-222-3p are Potential Biomarkers for Lymph Node Metastasis in Papillary Thyroid Carcinomas

2020 ◽  
Vol Volume 13 ◽  
pp. 1311-1319 ◽  
Author(s):  
Ke Jiang ◽  
Genpeng Li ◽  
Wenjie Chen ◽  
Linlin Song ◽  
Tao Wei ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Papillary Thyroid ◽  
Thyroid Carcinomas ◽  
Node Metastasis ◽  
Potential Biomarkers

Young Age and Male Sex Are Predictors of Large-Volume Central Neck Lymph Node Metastasis in Clinical N0 Papillary Thyroid Microcarcinomas

Thyroid ◽  
2017 ◽  
Vol 27 (10) ◽  
pp. 1285-1290 ◽  
Author(s):  
Hye-Seon Oh ◽  
Suyeon Park ◽  
Mijin Kim ◽  
Hyemi Kwon ◽  
Eyun Song ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Large Volume ◽  
Young Age ◽  
Central Neck ◽  
Papillary Thyroid ◽  
Neck Lymph Node ◽  
Node Metastasis ◽  
Neck Lymph Node Metastasis ◽  
Male Sex

scholarly journals The impact of ipsilateral central neck dissection on the 2015 American thyroid association risk stratification system and TNM staging in papillary thyroid carcinoma

2019 ◽  
Vol 5 (2) ◽  
pp. 247
Author(s):  
Gustavo C. Penna ◽  
Patricia F. Corradi ◽  
Henrique G. Mendes ◽  
Cynthia K. Berenstein ◽  
Magda C. Pires ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Lymph Node Metastasis ◽  
Neck Dissection ◽  
Central Neck Dissection ◽  
Tnm Staging ◽  
American Thyroid Association ◽  
Central Neck ◽  
Papillary Thyroid ◽  
Node Metastasis

<p class="abstract"><strong>Background:</strong> In patients with classic papillary thyroid carcinoma (PTC) and no clinical evidence of lymph node metastasis (cN0), elective central neck dissection remains controversial. This study evaluates whether elective ipsilateral central neck dissection (eICND) along with total thyroidectomy could modify the staging of these patients. Additionally, we aim to assess pN1 risk factors, the incidence of post-operative complications, and the correlation between pN1 and change in tumor classification according to the risk stratification score of the American thyroid association 2015 (ATA 2015-RSS) and the TNM Score.</p><p class="abstract"><strong>Methods:</strong> This is a prospective, observational study, involving 46 patients with cN0 PTC who underwent eICND along with total thyroidectomy. The number of metastatic lymph nodes, the largest lymph node metastasis, and the extra-nodal extension were assessed.  </p><p class="abstract"><strong>Results:</strong> 22 out of 46 patients (47.8%; CI 32.9–63.1) presented lymph node metastasis. Seventeen out of the 45 patients initially classified as low or intermediate ATA 2015-RSS upgraded their risk staging (37.8%; CI 23.8–53.5). Fourteen out of these reclassified patients had their initial ATA 2015-RSS changed due to lymph node metastasis larger than 2 mm (mostly between 3 mm and 4 mm). Ten out of 46 (21.7%; CI 10.49–36.4) patients had their TNM staging reviewed. General complication rate was 17.4% (8/46).</p><p class="abstract"><strong>Conclusions:</strong> Elective dissection of levels VI ipsilateral and VII showed the ability to upgrade the initial ATA 2015-RSS and TNM staging in patients with cN0 PTC. However, further studies are necessary to evaluate the clinical impact of lymph node micro-metastasis.</p>

Association Between Age and Nodal Metastasis in Papillary Thyroid Carcinoma

2020 ◽  
pp. 019459982096699
Author(s):  
Navika Shukla ◽  
Nosayaba Osazuwa-Peters ◽  
Uchechukwu C. Megwalu
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Lymph Node Metastasis ◽  
Thyroid Carcinoma ◽  
Population Based ◽  
Lateral Neck ◽  
Papillary Thyroid ◽  
Node Metastasis ◽  
Neck Disease

Objective To determine the relationship between age and rate of lymph node metastasis, nodal burden of disease, as well as rate of lateral neck disease in papillary thyroid cancer, especially in patients aged <30 years. Study Design Population-based cross-sectional study. Setting Population-based cancer database. Methods Data were extracted from the SEER 18 database (Surveillance, Epidemiology, and End Results) of the National Cancer Institute. The study cohort included 59,330 patients diagnosed with papillary thyroid cancer between 1988 and 2015. Patients aged 0 to 10 years, 11 to 20 years, and 21 to 30 years old were compared with those >30 years. All analyses were adjusted for sex, race, and T classification. Results The overall rate of lymph node metastasis was 26.11%, which increased with decreasing age. Adjusted odds ratios of lymph node metastasis were 7.19 (95% CI, 3.76-13.75) for the 0- to 10-year-old group, 3.45 (95% CI, 3.08-3.87) for the 11- to 20-year-old group, and 2.28 (95% CI, 2.15-2.41) for the 21- to 30-year-old group, relative to the group >30 years old. Decreased age was also associated with increased total positive nodes, increased lymph node ratio, and increased risk of lateral neck disease. Conclusion Pediatric and early young adult patients with papillary thyroid carcinoma have a greater risk of lymph node metastasis, greater burden of nodal disease, and a greater risk of lateral neck metastases.

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