Prognostic implications of extranodal extension in papillary thyroid carcinomas: A propensity score matching analysis and proposal for incorporation into current tumor, lymph node, metastasis staging

Surgery ◽  
2021 ◽  
Author(s):  
Li Genpeng ◽  
Zhang Pan ◽  
Wei Tao ◽  
Gong Rixiang ◽  
Zhu Jingqiang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Propensity Score ◽  
Propensity Score Matching ◽  
Papillary Thyroid ◽  
Thyroid Carcinomas ◽  
Propensity Score Matching Analysis ◽  
Node Metastasis ◽  
Extranodal Extension ◽  
Prognostic Implications

scholarly journals Prognosis of papillary thyroid cancer in patients with Graves’ disease: a propensity score-matched analysis

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Hyungju Kwon ◽  
Byung-In Moon
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Propensity Score ◽  
Propensity Score Matching ◽  
Graves Disease ◽  
Recurrence Free Survival ◽  
Papillary Thyroid ◽  
Free Survival ◽  
Node Metastasis

Abstract Background Patients with Graves’ disease (GD) are at a 2.5 times higher risk of developing thyroid cancer than the general population. Previous studies reported conflicting results about the prognosis of thyroid cancer concomitant with GD. This study aimed to investigate the effect of GD to the recurrence rates of papillary thyroid carcinoma (PTC). Methods We reviewed 3628 patients who underwent total thyroidectomy for PTC at the Ewha Womans University Medical Center from January 2006 to June 2014. Of those, 114 patients had non-occult PTC with concomitant GD. To reduce potential confounding effects and selection bias, we conducted 1:5 propensity score matching and analyzed the recurrence-free survival. Results Thyroid cancer in patients with GD showed lower rate of lymphatic invasion (1.8% vs. 6.7%; p = 0.037), microscopic resection margin involvement (0.9% vs. 5.8%; p = 0.024), and lymph node metastasis (29.8% vs. 37.3%; p = 0.001) than in patients without GD, respectively. During the median follow-up of 94.1 months, recurrence occurred in one patient (0.9%) with GD. After propensity score matching for adjusting clinicopathological features, 5-year recurrence-free survival was comparable between patients with GD and euthyroid patients (100% vs. 98.4%, p = 0.572). Both tumor size [hazard ratio (HR) 1.585, p < 0.001] and lymph node metastasis (HR for N1a 3.067, p = 0.024; HR for N1b 15.65, p < 0.001) were predictive factors for recurrence-free survival, while GD was not associated with the recurrence. Conclusions Our data suggest that GD does not affect the prognosis of PTC. Thyroid cancer in patients with GD is not more aggressive than in euthyroid patients.

scholarly journals Plasma Exosomal miR-146b-5p and miR-222-3p are Potential Biomarkers for Lymph Node Metastasis in Papillary Thyroid Carcinomas

2020 ◽  
Vol Volume 13 ◽  
pp. 1311-1319 ◽  
Author(s):  
Ke Jiang ◽  
Genpeng Li ◽  
Wenjie Chen ◽  
Linlin Song ◽  
Tao Wei ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Papillary Thyroid ◽  
Thyroid Carcinomas ◽  
Node Metastasis ◽  
Potential Biomarkers

Prognostic Significance of Tumor Deposits in Combination with Lymph Node Metastasis in Stage III Colon Cancer: A Propensity Score Matching Study

2020 ◽  
Vol 86 (2) ◽  
pp. 164-170
Author(s):  
Peilin Zheng ◽  
Chen Lai ◽  
Weimin Yang ◽  
Zhikang Chen
Keyword(s):  
Colon Cancer ◽  
Overall Survival ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Propensity Score ◽  
Confidence Interval ◽  
Propensity Score Matching ◽  
Stage Iii ◽  
Stage Iii Colon Cancer ◽  
Node Metastasis

Tumor deposits in colon cancer are related to poor prognosis, whereas the prognostic power of tumor deposits in combination with lymph node metastasis (LNM) is controversial. This study aimed to compare the overall survival between LNM alone and LNM in combination with tumor deposits, and to verify whether the number of tumor deposits can be considered LNM in patients with both LNM and tumor deposits in stage III colon cancer by propensity score matching (PSM). Patients carrying resected stage III adenocarcinoma of colon cancer were identified from the Surveillance, Epidemiology, and End Results database (2010–2015). The Kaplan-Meier method, Cox proportional hazard models and PSM were used. On the whole, 23,168 patients (20,451 (88.3%) with only LNM and 2,717 (11.7%) with both LNM and tumor deposits) were selected. After undergoing PSM, patients with both LNM and tumor deposits showed worse overall survival (hazard ratio = 1.33, 95% confidence interval: 1.20–1.47, P < 0.001). After the number of tumor deposits was added with that of positive regional lymph nodes, patients with both LNM and tumor deposits seemed to have prognostic implications similar to those with LNM alone (hazard ratio = 1.02, 95% confidence interval: 0.93–1.12, P = 0.66). The simultaneous presence of LNM and tumor deposits, as compared with the presence of only LNM, had an association with a worse outcome. Tumor deposits should be considered as LNM in patients with both tumor deposits and LNM in stage III colon cancer.

scholarly journals Extranodal Extension Is an Independent Predictor of Lung Metastasis in Papillary Thyroid Cancer

2021 ◽  
Author(s):  
Hu Hei ◽  
Wenbo Gong ◽  
Chen Zheng ◽  
Bin Zhou ◽  
Jianwu Qin
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Papillary Thyroid Cancer ◽  
Lung Metastasis ◽  
Multivariable Analysis ◽  
Cancer Center ◽  
Papillary Thyroid ◽  
Node Metastasis ◽  
Extranodal Extension

Abstract PurposeLymph node metastasis is common in patients with papillary thyroid cancer (PTC). Some metastatic lymph nodes may present extranodal extension (ENE). The clinical role of ENE in PTC has yet to be clearly identified. We evaluated macroscopic ENE as a potential prognostic indicator of lung metastasis in PTC.Patients and MethodsWe identified 1140 consecutive patients who had PTC initially resected at our cancer center. Clinical data and pathological results were reviewed. Univariate and multivariate logistic regression analyses were used to figure out the association between clinicopathological variables and lung metastasis.ResultsIn this cohort, 51.7% of PTC patients had lymph node metastasis; 10.4% had macroscopic ENE positive nodes; 2.3% had lung metastasis. In patients with lymph node metastasis, the average number of positive nodes was 5.10 ± 4.91. Multivariable analysis of clinicopathological factors revealed that extrathyroidal extension (odds ratio [OR], 3.57; 95% CI, 1.41–9.04), macroscopic ENE (OR, 7.08; 95% CI, 2.54–19.74), and number of positive nodes were significantly associated with lung metastasis. Compared with 0–3 positive nodes, 7–9 positive nodes denoted a moderate risk of lung metastasis (OR, 4.53; 95% CI, 1.03–19.85). And 10 positive nodes or more indicated a high risk of lung metastasis (OR, 9.63; 95% CI, 2.65–35.02).ConclusionMacroscopic ENE could serve as a strong independent prognostic factor of lung metastasis in PTC. More attention should be paid to patients with ENE positive nodes during follow-up.

Clinical and Imaging Assessment of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinomas

2010 ◽  
Vol 34 (7) ◽  
pp. 1494-1499 ◽  
Author(s):  
Yoon Jung Choi ◽  
Ji Sup Yun ◽  
Shin Ho Kook ◽  
Eun Choel Jung ◽  
Yong Lai Park
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cervical Lymph Node ◽  
Cervical Lymph Node Metastasis ◽  
Papillary Thyroid ◽  
Thyroid Carcinomas ◽  
Node Metastasis

scholarly journals Possible prediction of patterns of cervical lymph node spread based on primary tumor location in papillary thyroid carcinomas

2019 ◽  
Author(s):  
MEHMET ESER SANCAKTAR ◽  
GÜLESER SAYLAM ◽  
BÜLENT ÖCAL ◽  
AHMET ULUAT ◽  
ÖMER BAYIR ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Location ◽  
Central Neck ◽  
Lateral Neck ◽  
Papillary Thyroid ◽  
Regional Lymph Nodes ◽  
Neck Metastasis ◽  
Thyroid Carcinomas ◽  
Node Metastasis

Backround/aim: Papillary thyroid carcinomas (PTC) frequently metastasize to regional lymph nodes. We purposed to investigate the predictive role of tumor location for lymph node metastasis pattern in PTCs. Materials and methods: Medical records of 110 PTC patients were reviewed retrospectively. Tumor location was determined as upper, middle and lower pole according to ultrasonography (USG) findings. The effects of age, gender, tumor size and location on lymph node metastasis were investigated. Results: The series comprised 87% females (n:96), and 13% males (n:14). 43 patients had central neck metastasis (CNM), 14 had lateral neck metastasis (LNM). Upper pole tumors (UPT) metastasized to the central neck (CN) at a lower rate (17.6%) than middle (40.0%) or lower (48.5%) poles overall (p:0.104), while it was at a significantly lower rate (13.3%) in the PTC group (p<0.05). UPTs (n:17) metastasized to the lateral neck (LN) at almost 2-fold more. It was observed that 3 of 4 UPTs spread directly to the LN without CNM. Conclusion: In our opinion, UPTs have propensity to demonstrate metastase to LN rather than the CN in PTCs. Therefore, UPTs should be evaluated meticulously in terms of LNM. New studies could suggest that CN dissection is not performed for low risk PTCs in UPTs. Key words: Papillary thyroid cancer, lymph node metastase, tumor location

Sign in / Sign up

Export Citation Format

Share Document