A case of radiation-induced rectal cancer after an irradiation for cervical cancer.

Retraction of ‘Down-regulation of the radiation-induced pEGFRThr654 mediated activation of DNA-PK by Cetuximab in cervical cancer cells’ by Yunxiang Qi et al., RSC Adv., 2020, 10, 1132–1141, DOI: 10.1039/C9RA04962B.

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Sarcomatoid Carcinoma Manifesting as Recurrent Rectal Cancer and Mimicking Radiation-Induced Extraskeletal Osteosarcoma: A Case Report

International Journal of Surgical Pathology ◽

10.1177/1066896917715911 ◽

2017 ◽

Vol 25 (8) ◽

pp. 732-738 ◽

Cited By ~ 1

Author(s):

MiJo Lee ◽

Hyun-Jin Son ◽

Je-Ho Jang ◽

Hyun-Young Han ◽

Moon Hyang Park

Keyword(s):

Rectal Cancer ◽

Periodic Acid ◽

Neoadjuvant Chemoradiotherapy ◽

Sarcomatoid Carcinoma ◽

Gluteus Maximus ◽

Recurrent Rectal Cancer ◽

Extraskeletal Osteosarcoma ◽

Periodic Acid Schiff ◽

Calcified Tissue ◽

Radiation Induced

Here, we report an unusual case of sarcomatoid carcinoma mimicking extraskeletal osteosarcoma that manifested as recurrent rectal cancer. Five years earlier, a 76-year-old male patient had undergone neoadjuvant chemoradiotherapy followed by a laparoscopic low anterior resection due to adenocarcinoma of the rectum. He was admitted because of pain in the anus and left hip. He underwent abdominal computed tomography that revealed a newly developed left perirectal mass with gluteus maximus invasion measuring up to 8 cm, and therefore, an abdominoperineal resection was performed. Histologically, the tumor revealed sheets of spindled or epithelioid cells, an absence of gland formation, mucicarmine and periodic acid–Schiff stain negativity, and prominent intercellular deposits of osteoid-like calcified tissue. Tumor cells were diffusely immunoreactive for vimentin and cytokeratins. Ultrastructural examination demonstrated microvilli on the surface or within intercellular spaces. In this report, we also discuss the possible pathogenesis as well as the differential diagnosis.

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Identification of biomarkers for radiation-induced acute intestinal symptoms (RIAISs) in cervical cancer patients by serum protein profiling

Journal of Radiation Research ◽

10.1093/jrr/rru081 ◽

2014 ◽

Vol 56 (1) ◽

pp. 134-140 ◽

Cited By ~ 7

Author(s):

Y. Chai ◽

J. Wang ◽

Y. Gao ◽

T. Wang ◽

F. Shi ◽

...

Keyword(s):

Cervical Cancer ◽

Cancer Patients ◽

Serum Protein ◽

Protein Profiling ◽

Radiation Induced ◽

Intestinal Symptoms

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Sigmoidectomy for radiation-induced sigmoid colonic dysplasia 35 years after radiotherapy for cervical cancer

Clinical Journal of Gastroenterology ◽

10.1007/s12328-009-0120-x ◽

2009 ◽

Vol 2 (6) ◽

pp. 412-416

Author(s):

Kazuaki Uchimoto ◽

Fumikazu Koyama ◽

Hisao Fujii ◽

Tadashi Nakagawa ◽

Kenichi Ohtsuki ◽

...

Keyword(s):

Cervical Cancer ◽

Radiation Induced

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Radiation-induced lumbosacral plexopathy with severe burning pain after 17 years of radiation therapy for cervical cancer: a case report

Rinsho Shinkeigaku ◽

10.5692/clinicalneurol.cn-000706 ◽

2015 ◽

Vol 55 (9) ◽

pp. 654-656

Author(s):

Teppei Komatsu ◽

Masako Ikeda ◽

Masahiro Sonoo ◽

Toshiaki Hirai ◽

Hidetaka Mitsumura ◽

...

Keyword(s):

Cervical Cancer ◽

Radiation Therapy ◽

Case Report ◽

Burning Pain ◽

Lumbosacral Plexopathy ◽

Radiation Induced

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Radiation Induced Exacerbation of Bullous Pemphigoid in Rectal Cancer

Journal of Oncology Medicine & Practice ◽

10.4172/2576-3857.1000119 ◽

2018 ◽

Vol 03 (01) ◽

Author(s):

Issa Mohamad ◽

Tim Lymberiou ◽

Maysa Al Hussaini ◽

Khaled Dibs ◽

Jalal Qawasmeh ◽

...

Keyword(s):

Rectal Cancer ◽

Bullous Pemphigoid ◽

Radiation Induced

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Recurrent Intestinal Obstruction after Radiation Therapy: A Case Report and Review of the Literature

Case Reports in Surgery ◽

10.1155/2019/5198958 ◽

2019 ◽

Vol 2019 ◽

pp. 1-3

Author(s):

James Nguyen ◽

Amani Jambhekar ◽

Ziyad Nasrawi ◽

Prasad Gudavalli

Keyword(s):

Rectal Cancer ◽

Case Report ◽

Small Bowel ◽

Intestinal Obstruction ◽

Loop Ileostomy ◽

Neoadjuvant Chemoradiation ◽

Ileocolic Anastomosis ◽

Neoadjuvant Radiotherapy ◽

Diverting Loop Ileostomy ◽

Radiation Induced

Introduction. In patients who have undergone resection for rectal cancer after neoadjuvant radiotherapy, loop ileostomy is commonly performed with few serious complications. In rare cases, if this irradiated small bowel is strictured, reversal of the affected ileostomy can have dire consequences. We present a case of a 62-year-old male with recurrent intestinal obstruction after closure of his loop ileostomy. Case Report. RC is a 62-year-old male who initially presented with rectal cancer and underwent neoadjuvant chemoradiation prior to a laparoscopic low anterior resection with diverting loop ileostomy. He underwent elective reversal of his ileostomy and developed persistent postoperative obstruction. He underwent resection of the prior reversal site with normal-appearing dilated proximal bowel loops and collapsed distal bowel loops. He again developed an obstructive picture and underwent resection of the prior anastomosis with creation of an ileocolic anastomosis, after which he recovered well postoperatively. Conclusion. In patients who receive radiation adjuvant therapy for colon cancer, radiation-induced stricture should be considered as a cause of small bowel obstruction postoperative. In the setting of a longstanding ileostomy, evaluation of a defunctionalized distal ileum may be necessary to evaluate potential obstruction from radiation changes.

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Radiation-induced occult insufficiency fracture or bone metastasis after radiotherapy for cervical cancer? The nomogram based on quantitative apparent diffusion coefficients for discrimination

Cancer Imaging ◽

10.1186/s40644-020-00353-8 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Xi Zhong ◽

Huali Jiang ◽

Hui Mai ◽

Jialin Xiang ◽

Jiansheng Li ◽

...

Keyword(s):

Cervical Cancer ◽

Bone Marrow ◽

Bone Metastasis ◽

Bone Metastases ◽

Predictive Value ◽

Bone Lesions ◽

Potential Value ◽

Apparent Diffusion ◽

Adc Values ◽

Radiation Induced

Abstract Background Radiation-induced insufficiency fractures (IF) is frequently occult without fracture line, which may be mistaken as metastasis. Quantitative apparent diffusion coefficient (ADC) shows potential value for characterization of benign and malignant bone marrow diseases. The purpose of this study was to develop a nomogram based on multi-parametric ADCs in the differntiation of occult IF from bone metastasis after radiotherapy (RT) for cervical cancer. Methods This study included forty-seven patients with cervical cancer that showed emerging new bone lesions in RT field during the follow-up. Multi-parametric quantitative ADC values were measured for each lesion by manually setting region of interests (ROIs) on ADC maps, and the ROIs were copied to adjacent normal muscle and bone marrow. Six parameters were calculated, including ADCmean, ADCmin, ADCmax, ADCstd, ADCmean ratio (lesion/normal bone) and ADCmean ratio (lesion/muscle). For univariate analysis, receiver operating characteristic curve (ROC) analysis was performed to assess the performance. For combined diagnosis, a nomogram model was developed by using a multivariate logistic regression analysis. Results A total of 75 bone lesions were identified, including 48 occult IFs and 27 bone metastases. There were significant differences in the six ADC parameters between occult IFs and bone metastases (p < 0.05), the ADC ratio (lesion/ muscle) showed an optimal diagnostic efficacy, with an area under ROC (AUC) of 0.887, the sensitivity of 95.8%, the specificity of 81.5%, respectively. Regarding combined diagnosis, ADCstd and ADCmean ratio (lesion/muscle) were identified as independent factors and were selected to generate a nomogram model. The nomogram model showed a better performance, yielded an AUC of 0.92, the sensitivity of 91.7%, the specificity of 96.3%, positive predictive value (PPV) of 97.8% and negative predictive value (NPV) of 86.7%, respectively. Conclusions Multi-parametric ADC values demonstrate potential value for differentiating occult IFs from bone metastasis, a nomogram based on the combination of ADCstd and ADCmean ratio (lesion/muscle) may provide an improved classification performance.

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