Effectiveness of two probiotics in preventing necrotising enterocolitis in a cohort of very-low-birth-weight premature new-borns

2021 ◽  
pp. 1-8
Author(s):  
J. Uberos ◽  
A. Campos-Martinez ◽  
E. Fernandez-Marín ◽  
I. Cubero Millan ◽  
A. Ruiz Lopez ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Lactobacillus Acidophilus ◽  
Neonatal Intensive Care ◽  
Prospective Observational Study ◽  
Very Low Birth Weight ◽  
Bifidobacterium Bifidum ◽  
Necrotising Enterocolitis ◽  
Probiotic Supplementation ◽  
Different Strains

According to previous research, the incidence of necrotising enterocolitis (NEC) decreases after supplementation with probiotics. However, few studies have considered the equivalence or otherwise of different strains of probiotics in this respect. Accordingly, this prospective observational study was conducted in a cohort of 245 very-low-birth-weight (VLBW) new-borns to assess the prevalence of NEC after supplementation with the probiotic Inforan® (Berna Biotech, Madrid, Spain) 250 mg capsules containing 109 cfu of Lactobacillus acidophilus (ATCC 4356) and 109 cfu of Bifidobacterium bifidum (ATCC 15696); or with Bivos® (Ferring, Madrid, Spain) containing Lacticaseibacillus (formerly Lactobacillus) rhamnnosus (LGG) (ATCC 53103) (109 cfu); or with no probiotic supplementation. Statistical analysis was performed using multivariant regression for the duration of parenteral nutrition, length of neonatal intensive care unit stay, use of oxygen therapy and presence of chorioamnionitis. Of the VLBW new-borns in the study group, 65 received Infloran, 108 received Bivos and 72 received no probiotic. A significant association was observed between a reduced presence of NEC Stage ≥2 and probiotic supplementation. The odds risk (OR) obtained was 0.174 (95% confidence interval (CI): 0.032-0.936) for Infloran and 0.196 (95%CI: 0.053-0.732) for Bivos. Therefore, both probiotics are associated with a lower prevalence of NEC in VLBW new-borns, with no significant differences.

scholarly journals Probiotics to prevent necrotising enterocolitis and nosocomial infection in very low birth weight preterm infants

2017 ◽  
Vol 117 (7) ◽  
pp. 994-1000 ◽  
Author(s):  
J. Uberos ◽  
E. Aguilera-Rodríguez ◽  
A. Jerez-Calero ◽  
M. Molina-Oya ◽  
A. Molina-Carballo ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Necrotising Enterocolitis ◽  
Stage Ii ◽  
Preterm Neonates ◽  
Probiotic Supplementation ◽  
Late Onset Sepsis ◽  
Reduced Risk

AbstractThe aim of the study was to determine whether routine probiotic supplementation (RPS) with Lactobacillus rhamnosus GG (LGG) or Lactobacillus acidophilus +Lactobacillus bifidum is associated with reduced risk of necrotising enterocolitis (NEC)≥Stage II in preterm neonates born at ≤32 weeks’ gestation. We conducted a retrospective cohort study on the effect of probiotic supplementation in very low birth weight infants in our neonatal unit by comparing two periods: before and after supplementation. The incidence of NEC≥Stage II, late-onset sepsis and all-cause mortality was compared for an equal period ‘before’ (Period I) and ‘after’ (Period II) RPS with LGG or L. acidophillus+L. bifidum. Multivariate logistic regression analysis was conducted to adjust for relevant confounders. The study population was composed of 261 neonates (Period I v. II: 134 v. 127) with comparable gestation duration and birth weights. In <32 weeks, we observed a significant reduction in NEC≥Stage II (11·3 v. 4·8 %), late-onset sepsis (16 v. 10·5 %) and mortality (19·4 v. 2·3 %). The benefits in neonates aged ≤27 weeks did not reach statistical significance. RPS with LGG or L. acidophillus+L. bifidum is associated with a reduced risk of NEC≥Stage II, late-onset sepsis and mortality in preterm neonates born at ≤32 weeks’ gestation.

Transfusion-associated necrotising enterocolitis in very low birth weight premature infants

2012 ◽  
Vol 22 (5) ◽  
pp. 332-337 ◽  
Author(s):  
G. Demirel ◽  
I. H. Celik ◽  
H. T. Aksoy ◽  
O. Erdeve ◽  
S. S. Oguz ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Premature Infants ◽  
Very Low Birth Weight ◽  
Necrotising Enterocolitis

Device-associated pneumonia of very low birth weight infants in Polish Neonatal Intensive Care Units

2016 ◽  
Vol 61 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Jadwiga Wójkowska-Mach ◽  
T. Allen Merritt ◽  
Maria Borszewska-Kornacka ◽  
Joanna Domańska ◽  
Ewa Gulczyńska ◽  
...  
Keyword(s):  
Intensive Care ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Intensive Care Units ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Neonatal Intensive Care Units ◽  
Low Birth Weight Infants

Very Low Birth Weight Outcomes

PEDIATRICS ◽  
1992 ◽  
Vol 89 (2) ◽  
pp. 357-357
Author(s):  
HELEN HARRISON
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Meta Analysis ◽  
Low Birth Weight Infants ◽  
Randomized Controlled Clinical Trials ◽  
Weight Outcomes ◽  
Term Evaluation

To the Editor.— The authors of the National Institute of Child Health and Human Development report on neonatal care1 found "important" variations among neonatal intensive care units in philosophies of treatment, methods of treatment, and short-term outcomes. In a recent meta-analysis of follow-up studies,2 researchers document a similarly haphazard approach to the long-term evaluation of very low birth weight survivors. Until randomized controlled clinical trials validate the safety and efficacy of neonatal therapies, and until long-term outcomes are assessed accurately, the treatment of very low birth weight infants should be declared experimental.

scholarly journals GROWTH OF VERY LOW BIRTH WEIGHT PRETERM UNTIL 12 MONTHS OF CORRECTED AGE

2015 ◽  
Vol 25 (3) ◽  
pp. 351 ◽  
Author(s):  
Milene De Moraes Sedrez Rover ◽  
Cláudia Silveira Viera ◽  
Beatriz Rosana G. de Oliveira Toso ◽  
Sabrina Grassiolli ◽  
Bruna Maria Bugs
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Progressive Increase ◽  
Z Score ◽  
Monitoring Methods ◽  
Male Birth ◽  
Growth Changes

Introduction: facing the progressive increase in the survival of premature ta infants, a concern for health professionals would be related to the possible consequences arising from prematurity, among them the growth changes. Objectives: to describe the anthropometric variables of newborns Premature Very Low Birth Weight in the follow-up monitoring. Methods: observational, longitudinal and retrospective study, involving 71 children who left Neonatal Intensive Care Unit (NICU), with a weight lower than 1500 g who were treated between 2006 and 2013. They should have at least three outpatient visits within twelve months of corrected age after NCAU discharge, in the following periods: period I up to 3 months of corrected age; period II between 4-6 months of corrected age and period III between 7-12 months of corrected age. Results: the mean Gestational Age (GA) was 29.4 weeks, 51% male, birth weight 1073.2 g, 70% with appropriate GA. The hospitalization stay was 68.73 days. Weight Z score at birth -0.95; at discharge -3.05; in period I -2.4; period II -1.8; period III -1.2. Height at birth -1.21, at discharge -2.23; -2.5; -1.8 and -1.1 for the periods I, II and III , respectively. Regarding the PT Z score at birth -0.71; at discharge -1.5; and monitoring -1.1; - 0.8 and -0.5 respectively in the periods I, II and III. Conclusions: despite of the great Z score reduction in NICU, there was a progressive improvement during follow-up in the Z score in the three anthropometric variables.

scholarly journals Gastric residual volume as a measure of feed intolerance/necrotising enterocolitis in very low birth weight infants: an observational cohort study

2020 ◽  
Vol 7 (2) ◽  
pp. 432
Author(s):  
Rahul M. Kadam ◽  
Lakshmi Aparna Devi V. V.
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Observational Cohort Study ◽  
Necrotising Enterocolitis ◽  
Residual Volume ◽  
Gastric Residual Volume ◽  
Observational Cohort ◽  
Feed Intolerance

Background: To evaluate the efficacy of Gastric Residual Volume (GRV) as a measure of feed intolerance /Necrotising enterocolitis in Very Low Birth Weight (VLBW) infants.Methods: This prospective observational cohort study was done in a tertiary care hospital located in rural South India for a period of 2 years. All haemodynamically stable infants born between 30-34 weeks of gestation at birth and 1000-1500 grams of birth weight, admitted to Neonatal Intensive Care Unit (NICU) within first 24 hours of life during study period were enrolled in two groups; GRV group, where pre-feed gastric residual volume  was checked and No-GRV group, where pre-feed gastric residual volume  was not checked.Results: Both groups had similar baseline characteristics. In No-GRV group, the days to reach birth weight (12.1) and days to attain full feeds (8.0) were less when compared to GRV group. In No-GRV group, average duration of NICU stay in days (16.60) and parenteral nutrition (5.25) was less when compared to GRV group. No-GRV group does not have increased incidence of sepsis or mortality compared to GRV group. In this study there was increased incidence of NEC noted in GRV group (30%) when compared to No-GRV group (p value-0.02).Conclusions: In hemodynamically stable preterm VLBW infants, it is recommended not to check gastric residual volume routinely prior to the enteral feeding.

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