scholarly journals Effects of Methanol Leaf Extract of Aristolochia bracteolata on Diethylnitrosamine Induced Hepatocellular Carcinoma in Rats

2022 ◽  
Vol 12 (1) ◽  
pp. 1-12
Author(s):  
I.B. Gabriel ◽  
K. Christophe ◽  
H.A. Umaru ◽  
D. Dahiru
Keyword(s):  
Hepatocellular Carcinoma ◽  
Leaf Extract ◽  
Aristolochia Bracteolata

scholarly journals Apoptotic and Inhibitory Effects on Cell Proliferation of Hepatocellular Carcinoma HepG2 Cells by Methanol Leaf Extract ofCostus speciosus

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Sandhya V. G. Nair ◽  
Menik Hettihewa ◽  
H. P. Vasantha Rupasinghe
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Cycle ◽  
Hepg2 Cells ◽  
Cell Cycle Progression ◽  
Leaf Extract ◽  
Methanol Extract ◽  
Signal Molecules ◽  
Treatment Regimes ◽  
Ayurvedic Treatment

Costus speciosusis a medicinal plant commonly known as wild ginger distributed in South and Southeast Asian countries. Leaves of this plant are used for ayurvedic treatment regimes in malignancies and mental illness. Rhizome extract from the plant is used to treat malignancies, pneumonia, urinary disorders, jaundice, rheumatism, and diabetes. The goal of this study was to investigate the effects of methanol extract of leaves ofC. speciosuson the growth of human hepatocellular carcinoma (HepG2) cells and understand possible mechanisms of its action. Viability of HepG2 cells were measured by MTS assay after 24 h and 48 h treatment with extracts of 1, 10, 50, 100, and 200 μg/mL concentrations. Cell cycle analysis and apoptosis were evaluated by flow cytometry and caspase-3 induction. HepG2 cells treated with 100 μg/mL methanol leaf extract for 24 h displayed a significant reduction in cell viability(P≤0.05). The methanol extract perturbed cell cycle progression, modulated cell cycle and regulated, signal molecules were involved in induction of apoptosis in HepG2 cells. Our findings indicate that phytochemicals of leaves ofC. speciosusshows potential for natural therapeutic product development for hepatocellular carcinoma. This is the first report to demonstratein vitroanticancer activity of leaf extract ofC. speciosusin relation to liver cancer.

scholarly journals The chemo-prophylactic efficacy of an ethanol Moringa oleifera leaf extract against hepatocellular carcinoma in rats

2017 ◽  
Vol 55 (1) ◽  
pp. 1458-1466 ◽  
Author(s):  
Kadry M. Sadek ◽  
Tarek K. Abouzed ◽  
Reham Abouelkhair ◽  
Sherif Nasr
Keyword(s):  
Hepatocellular Carcinoma ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
Prophylactic Efficacy

Multimodality treatment of hepatocellular carcinoma

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S315-S319 ◽  
Author(s):  
ZHAO-YOU TANG ◽  
XIN-DA ZHOU ◽  
ZENG-CHEN MA ◽  
ZHI-QUAN WU ◽  
JIA FAN ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Multimodality Treatment

Hepatocellular carcinoma

1982 ◽  
Vol 118 (1) ◽  
pp. 69-70 ◽  
Author(s):  
A. J. Bennett
Keyword(s):  
Hepatocellular Carcinoma
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