Protective Effect of Phyllanthus polyphyllus on Human Umbilical Vein Endothelial Cells against Glycated Protein-Iron Chelate Induced Toxicity

2007 ◽  
Vol 7 (6) ◽  
pp. 961-968
Author(s):  
Rajkapoor Balasubram ◽  
Venugopal Ramachandr ◽  
Sakthisekaran Dhanapal ◽  
Zhang Hao Qian ◽  
Ikuo Nishigaki
Keyword(s):  
Endothelial Cells ◽  
Protective Effect ◽  
Umbilical Vein ◽  
Iron Chelate ◽  
Human Umbilical Vein ◽  
Glycated Protein ◽  
Umbilical Vein Endothelial Cells

Protective Effect of Fresh Apple Skin Extract on Human Umbilical Vein Endothelial Cells Against Glycated Protein-iron Chelate Induced Toxicity

2007 ◽  
Vol 2 (2) ◽  
pp. 34-42
Author(s):  
Ikuo Nishigaki ◽  
Balasubramanian Rajkapoor ◽  
Ramachandran Venugopal ◽  
Palaniyandi Senthilnat ◽  
Hao Qian Zhang ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Protective Effect ◽  
Umbilical Vein ◽  
Skin Extract ◽  
Iron Chelate ◽  
Human Umbilical Vein ◽  
Glycated Protein ◽  
Umbilical Vein Endothelial Cells

Cytoprotective role of astaxanthin against glycated protein/iron chelate-induced toxicity in human umbilical vein endothelial cells

2009 ◽  
Vol 24 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Ikuo Nishigaki ◽  
Peramaiyan Rajendran ◽  
Ramachandran Venugopal ◽  
Gnapathy Ekambaram ◽  
Dhanapal Sakthisekaran ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Umbilical Vein ◽  
Iron Chelate ◽  
Human Umbilical Vein ◽  
Glycated Protein ◽  
Umbilical Vein Endothelial Cells

scholarly journals Effect of Extract of Pomegranate (Punica granatum L.) on Glycated Protein-iron Chelate-induced Toxicity: An In Vitro Study on Human Umbilical-vein Endothelial Cells

2008 ◽  
Vol 54 (4) ◽  
pp. 441-449 ◽  
Author(s):  
Ikuo Nishigaki ◽  
Peramaiyan Rajendran ◽  
Ramachandran Venugopal ◽  
Ganapathy Ekambaram ◽  
Dhanapal Sakthisekaran ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Umbilical Vein ◽  
In Vitro Study ◽  
Punica Granatum ◽  
Iron Chelate ◽  
Human Umbilical Vein ◽  
Glycated Protein ◽  
Umbilical Vein Endothelial Cells ◽  
Punica Granatum L

scholarly journals The protective effect of thymoquinone on tert-butylhydroquinone induced cytotoxicity in human umbilical vein endothelial cells

2019 ◽  
Vol 8 (6) ◽  
pp. 1050-1056
Author(s):  
Zahra Karimi ◽  
Maryam Ghaffari ◽  
Jafar Ezzati Nazhad Dolatabadi ◽  
Parvin Dehghan
Keyword(s):  
Endothelial Cells ◽  
Protective Effect ◽  
Food Industry ◽  
Umbilical Vein ◽  
Protective Agent ◽  
Protective Effects ◽  
Oxidative Rancidity ◽  
Dapi Staining ◽  
Human Umbilical Vein ◽  
Umbilical Vein Endothelial Cells

Abstract 2-tert-Butyl-4-hydroquinone (TBHQ) is used for inhibition of oxidative rancidity in the food industry. However, this antioxidant can stimulate cytotoxicity in human umbilical vein endothelial cells (HUVECs). Thus, potential protective effects of thymoquinone (TQ) against TBHQ-induced cytotoxicity were investigated. Cytotoxicity was evaluated via MTT, flow cytometry, DAPI staining and DNA fragmentation methods. The obtained results revealed that treatment of HUVECs with TQ enhanced the cell viability rate and it had potential to reduce the cytotoxicity effect of TBHQ in cells. Also, in a combined regime of TQ and TBHQ, apoptosis was reduced compared to the cells treated with TBHQ (p < 0.05). Similarly, TQ had a protective effect on DNA and chromatin fragmentation of the cells treated with TBHQ. Finally, it can be concluded that TQ could be used as a protective agent against cytotoxicity induced by TBHQ in HUVECs.

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