Effects of Topical Mitomycin C on the Ciliary Body and Intraocular Pressure After PRK: An Experimental Study

Aim: To determine the effect of intraoperative adjunctive topical mitomycin C on intraocular pressure in patients undergoing pterygium excision.Methods: This was a descriptive interventional case series of 102 patients (118 eyes) with different grades of pterygium treated from 1995 to 2008. All patients underwent pterygium excision with intraoperative mitomycin C 0.2 mg/mL administered for 1 to 5 minutes. Changes in intraocular pressure were recorded on days 1 and 7, and at 3 months. Data were analysed using proportion, group means, standard deviations, analysis of variance, and paired Student t test.Results: There was no significant decline in intraocular pressure throughout the follow-up period (p = 0.435, Student t test). At 3 months postoperatively, 109 eyes (92.4%) had no changes in intraocular pressure >5 mm Hg, of whom 78 (72%) experienced minimal changes that were not statistically significant.Conclusions: Intraoperative topical administration of mitomycin C has a minimal effect on lowering intraocular pressure in patients with pterygium. These results do not support the trans-scleral effect of mitomycin C on the ciliary body as an intraocular pressure–lowering mechanism in glaucoma filtering surgery.

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Intraocular pressure reduction after subconjunctival mitomycin-C in absolute glaucomatous eyes

Annals of Ophthalmology ◽

10.1007/s12009-001-0006-0 ◽

2001 ◽

Vol 33 (2) ◽

pp. 122-124

Author(s):

Viney Gupta ◽

H. C. Agarwal

Keyword(s):

Intraocular Pressure ◽

Mitomycin C ◽

Pressure Reduction ◽

Intraocular Pressure Reduction

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Avoiding BAK in postoperative eye drops reduces the need for subconjunctival 5-FU injections post-trabeculectomy

Asian Journal of Ophthalmology ◽

10.35119/asjoo.v17i1.643 ◽

2020 ◽

Vol 17 (1) ◽

pp. 128-131

Author(s):

Keith Ong ◽

Leonard Ong

Keyword(s):

Intraocular Pressure ◽

Mitomycin C ◽

T Test ◽

Topical Steroids ◽

Eye Drops ◽

Filtration Surgery ◽

Glaucoma Filtration Surgery ◽

Group A ◽

Group B ◽

Causes Of Failure

Purpose: Subconjunctival fibrosis is one of the main causes of failure of glaucoma filtration surgery. It can result in absence of a filtration bleb, a small scarred bleb, or a cystic bleb. 5-Fluorouracil (5-FU), mitomycin C (MMC), and topical steroids have been used to suppress subconjunctival fibrosis. Method: A study was done analyzing the number of postoperative subconjunctival 5-FU injections for trabeculectomy on pseudophakic eyes prior to and following the change to a BAK-free regimen. The cohort consisted of 16 consecutive cases undergoing primary trabeculectomy without intraoperative MMC or 5-FU. The trabeculectomy surgery included a groove sclerectomy procedure. Group A were 8 eyes of patients who had the author’s standard Chlorsig, Maxidex, and Prednefrin Forte eye drops tds. Group B were 8 eyes who had Chlorsig-dexamethasone and Optive-dexamethasone tds eye drops postoperatively. Results: Group B (BAK-free) patients required fewer postoperative 5-FU subconjunctival injections (average: 2.9, range: 1-5 injections) compared to Group A (BAK) patients (average: 7.3, range: 4-18 injections). This difference was statistically significant (P = 0.02, unpaired t-test). All patients had functioning blebs and did not require glaucoma medications to maintain target intraocular pressure. The Group B (BAK-free) patients had more diffuse blebs than the Group A (BAK) patients. Conclusion: The results demonstrated that when BAK was eliminated from postoperative eye drops in trabeculectomy, the number of postoperative 5-FU injections was reduced.

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Low Intraocular Pressure Resulting from Ciliary Body Detachment in Patients with Myotonic Dystrophy

Ophthalmology ◽

10.1016/j.ophtha.2010.06.020 ◽

2011 ◽

Vol 118 (2) ◽

pp. 260-264 ◽

Cited By ~ 39

Author(s):

Nicola Rosa ◽

Michele Lanza ◽

Maria Borrelli ◽

Maddalena De Bernardo ◽

Alberto Palladino ◽

...

Keyword(s):

Intraocular Pressure ◽

Myotonic Dystrophy ◽

Ciliary Body

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The role of mitomycin C and porcine extracellular matrix in phacotrabeculectomy

European Journal of Ophthalmology ◽

10.1177/1120672120944339 ◽

2020 ◽

pp. 112067212094433 ◽

Cited By ~ 1

Author(s):

Momen Mahmoud Hamdi ◽

Islam Mahmoud Hamdi

Keyword(s):

Extracellular Matrix ◽

Intraocular Pressure ◽

Mitomycin C ◽

Low Dose ◽

Open Angle Glaucoma ◽

Group Iii ◽

Group I ◽

Pressure Lowering ◽

The Mean

Purpose: To compare between mitomycin C alone, porcine extracellular matrix alone, and combined low dose mitomycin C with porcine extracellular matrix in term of efficacy and safety in phaco-trabeculectomy surgery. Study design: Prospective comparative. Methods: Sixty eyes of 60 patients complaining of primary open angle glaucoma and cataract, undergoing phaco-trabeculectomy, were distributed into three groups: group I: surgery was augmented with mitomycin C, group II with porcine extracellular matrix, and group III with porcine extracellular matrix combined with low dose mitomycin C. Intraocular pressure was evaluated, postoperatively, at day 1, week 1, and 1, 3, 6, 9, and 12 months. Bleb vascularity, pre- and post-operative intraocular pressure lowering medications, success of IOP control and complications were also evaluated. Results: After 12 months, the mean preoperative intraocular pressure (mm Hg) improved from 30.85 ± 4.7, 33.8 ± 4.2, and 31.05 ± 5.4 mm Hg, in groups I, II, and III respectively, to 13.8 ± 4.7 (55.2%), 15.2 ± 4.8 (55%), and 13 ± 4.9 (58.1%) ( p > 0.05). Success of IOP control, postoperative IOP lowering medications and complications were comparable ( p > 0.05). Bleb vascularity was significantly different ( p < 0.05). Conclusion: Mitomycin C, porcine extracellular matrix and their combination are equally effective in phacotrabeculectomy.

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Treatment of chronic and extreme ocular hypotension following glaucoma surgery with intraocular platelet-rich plasma: A case report

European Journal of Ophthalmology ◽

10.1177/1120672118803515 ◽

2018 ◽

Vol 29 (4) ◽

pp. NP9-NP12 ◽

Cited By ~ 2

Author(s):

Omneya Abdalrahman ◽

Alejandra E Rodriguez ◽

Jorge L Alio Del Barrio ◽

Jorge L Alio

Keyword(s):

Intraocular Pressure ◽

Anterior Chamber ◽

Mitomycin C ◽

Platelet Rich Plasma ◽

Corneal Edema ◽

Glaucoma Surgery ◽

Applanation Tonometry ◽

Safe Procedure ◽

Rieger Syndrome ◽

Ocular Hypotony

Purpose: To report a new approach for the treatment of severe ocular hypotony secondary to glaucoma filtering surgery with mitomycin C by injecting autologous eye platelet-rich plasma (E-PRP) in the anterior chamber to block excessive diffuse filtration through an abnormally thinned sclera. Methods: A 49-year-old patient with the Axenfeld–Rieger syndrome and severe chronic hypotony and corneal edema following filtering glaucoma surgery with mitomycin C received an isolated injection of 0.3 mL of autologous platelet-rich plasma in the anterior chamber. Results: Intraocular pressure measured by Goldman’s applanation tonometry 6 h after the procedure improved to 18 mmHg. Intraocular pressure remained stable along the full follow-up period of 6 month. No filtration or hypotony or any other complications were observed. Conclusion: Intracameral platelet-rich plasma (E-PRP) injection was an effective, rapidly effective, and safe procedure for treatment of severe chronic ocular hypotony following glaucoma filtrating surgery.

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