The effects of mitomycin C and 5-fluorouracil/triamcinolone on fibrosis/scar tissue formation secondary to subglottic trauma (experimental study)

2005 ◽  
Vol 26 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Hakan Cincik ◽  
Atila Gungor ◽  
Adem Cakmak ◽  
Atilla Omeroglu ◽  
Ethem Poyrazoglu ◽  
...  
Keyword(s):  
Experimental Study ◽  
Mitomycin C ◽  
Scar Tissue ◽  
Tissue Formation ◽  
Scar Tissue Formation

Study of Wound Healing in Rats Treated with Topical and Injected Mitomycin C

2008 ◽  
Vol 117 (10) ◽  
pp. 786-790 ◽  
Author(s):  
Fernando de Andrade Quintanilha Ribeiro ◽  
Lusiele Guaraldo ◽  
Janaina de Pádua Borges ◽  
Maria Regina Vianna ◽  
Claudia A. Eckley
Keyword(s):  
Mitomycin C ◽  
Topical Treatment ◽  
Healing Process ◽  
Microscopic Analysis ◽  
Scar Tissue ◽  
Control Group ◽  
Tissue Formation ◽  
Chemotherapeutic Drug ◽  
Surgical Wounds ◽  
Scar Tissue Formation

Objectives: Mitomycin C, a widely used chemotherapeutic drug, has been proposed as a potential adjuvant for the control of scar tissue in surgical wounds because of its capacity to inhibit fibroblast proliferation. The current study used a combination of topical and injected mitomycin C to slow the healing process of surgical wounds in rats. Methods: An experimental model of surgical wounding at the dorsum of rats was used. A total of 43 animals were subdivided into 3 groups: Control, topical mitomycin C, and a combination of topical treatment and intradermal injections of the drug at 30 and 60 days after the initial topical treatment. After 3 months, the animals were painlessly sacrificed and the surgical scars were removed for microscopic analysis. Results: The group that received only topical mitomycin C presented milder inflammatory signs and consequently had a less intense healing process than the control group. The group treated with a combination of both topical and injected mitomycin C presented results comparable to those of the control group. Conclusions: The toxic characteristics of mitomycin C were most likely responsible for the greater tissue damage that occurred when it was used in the injected form, causing increased scar tissue formation. Mitomycin C slows the healing process of surgical wounds when used topically, but causes enhanced scar tissue formation when injected.

scholarly journals Experimental Methods to Simulate and Evaluate Postsurgical Peripheral Nerve Scarring

2021 ◽  
Vol 10 (8) ◽  
pp. 1613
Author(s):  
Alessandro Crosio ◽  
Giulia Ronchi ◽  
Benedetta Elena Fornasari ◽  
Simonetta Odella ◽  
Stefania Raimondo ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Peripheral Nerves ◽  
Experimental Methods ◽  
Scar Tissue ◽  
Experimental Models ◽  
Tissue Formation ◽  
Surgical Interventions ◽  
Pubmed Database ◽  
Different Types ◽  
Scar Tissue Formation

As a consequence of trauma or surgical interventions on peripheral nerves, scar tissue can form, interfering with the capacity of the nerve to regenerate properly. Scar tissue may also lead to traction neuropathies, with functional dysfunction and pain for the patient. The search for effective antiadhesion products to prevent scar tissue formation has, therefore, become an important clinical challenge. In this review, we perform extensive research on the PubMed database, retrieving experimental papers on the prevention of peripheral nerve scarring. Different parameters have been considered and discussed, including the animal and nerve models used and the experimental methods employed to simulate and evaluate scar formation. An overview of the different types of antiadhesion devices and strategies investigated in experimental models is also provided. To successfully evaluate the efficacy of new antiscarring agents, it is necessary to have reliable animal models mimicking the complications of peripheral nerve scarring and also standard and quantitative parameters to evaluate perineural scars. So far, there are no standardized methods used in experimental research, and it is, therefore, difficult to compare the results of the different antiadhesion devices.

scholarly journals VEGF Receptor-2 Activation Mediated by VEGF-E Limits Scar Tissue Formation Following Cutaneous Injury

2018 ◽  
Vol 7 (8) ◽  
pp. 283-297 ◽  
Author(s):  
Lyn M. Wise ◽  
Gabriella S. Stuart ◽  
Nicola C. Real ◽  
Stephen B. Fleming ◽  
Andrew A. Mercer
Keyword(s):  
Scar Tissue ◽  
Vegf Receptor ◽  
Tissue Formation ◽  
Cutaneous Injury ◽  
Scar Tissue Formation

Identifying wound infections for veterinary nurses

2020 ◽  
Vol 11 (10) ◽  
pp. 447-451
Author(s):  
Amanda Curtis
Keyword(s):  
Healing Process ◽  
Scar Tissue ◽  
Care Practice ◽  
Wound Infections ◽  
Tissue Formation ◽  
Deep Tissue ◽  
The Difference ◽  
Bite Wounds ◽  
Major Factors ◽  
Scar Tissue Formation

Heavily contaminated wounds are a common occurrence in both referral and primary care practice, with traumatic and bite wounds being among the most typical aetiologies seen. Each type of wound can be affected by numerous factors that can inhibit the healing process, one of these major factors is infection. Wound infections and the formation of biofilms can present veterinary nurses with a variety of challenges, which is why it is important that we understand the difference between normal inflammatory signs and the signs of infection. The early identification of infection and biofilms within a wound can influence healing times, scar tissue formation and length of healing. This article aims to highlight the difference between inflammation and infection, the different levels of contamination within a wound, and ways to decipher between superficial and deep tissue infections.

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