Association of Retinal Inner Layer Disorganization With Ultra-Widefield Fluorescein Angiographic Features and Visual Acuity in Branch Retinal Vein Occlusion

Purpose: This work aims to investigate real-world treatment patterns and outcomes in eyes with branch retinal vein occlusion in the antivascular endothelial growth factor (anti-VEGF) era. Methods: A retrospective, nonrandomized, comparative study was conducted on eyes diagnosed with branch retinal vein occlusion at a single tertiary center between 2009 and 2017. Medical history, treatment patterns, and visual acuity outcomes were examined. Subanalysis was performed for eyes that met the eligibility criteria for the BRAVO (Ranibizumab for the Treatment of Macular Edema Following Branch Retinal Vein Occlusion) trial. Results: A total of 315 eyes were included, of which 244 were treatment naive. In all eyes, the most common first treatment was the following: intravitreal bevacizumab (38.4%), aflibercept (15.1%), ranibizumab (8.1%), sectoral scatter laser (6.2%), and triamcinolone (3.1%). At 1 year, treatment-naive eyes had received an average of 2.43 anti-VEGF injections. During follow-up, treatment-naive eyes gained an average of 0.21 Early Treatment Diabetic Retinopathy Study lines. Forty eyes that met BRAVO trial criteria received an average of 5.05 anti-VEGF injections in the first year and gained an average of 1.83 Early Treatment Diabetic Retinopathy Study lines. Conclusions: This real-world cohort received fewer anti-VEGF injections at year 1 and experienced less improvement in visual acuity during the course of treatment than clinical trial participants. Trial-eligible patients received more injections and had greater visual gains than those who would not have been eligible for the trial.

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Relationship between central retinal sensitivity, thickness, perfusion density and visual acuity in patients with branch retinal vein occlusion

Acta Ophthalmologica ◽

10.1111/aos.14841 ◽

2021 ◽

Author(s):

Kazutaka Hirabayashi ◽

Ken Hoshiyama ◽

Akira Imai ◽

Yasuhiro Iesato ◽

Takao Hirano ◽

...

Keyword(s):

Visual Acuity ◽

Retinal Vein Occlusion ◽

Branch Retinal Vein Occlusion ◽

Retinal Sensitivity ◽

Vein Occlusion ◽

Perfusion Density

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Vitrectomy for branch retinal vein occlusion with vitreous hemorrhage: proposal for a new grading system

10.21203/rs.2.24718/v1 ◽

2020 ◽

Author(s):

Gengmin Tong ◽

Xuting Hu ◽

Chenlei Zhu ◽

Zhiqiang Gao ◽

Xuhao Chen ◽

...

Keyword(s):

Visual Acuity ◽

Retinal Vein Occlusion ◽

Branch Retinal Vein Occlusion ◽

Vitreous Hemorrhage ◽

Grading System ◽

Vein Occlusion ◽

Number Of Patients ◽

Surgical Methods ◽

Significant Difference ◽

Grade Iii

Abstract Purpose To investigate the long-term surgical outcomes after treatment with pars plana vitrectomy (PPV) combined with photocoagulation in different severities of branch retinal vein occlusion (BRVO) with vitreous hemorrhage (VH) in order to propose a new grading system. Methods We retrospectively reviewed the medical records of 117 eyes of 117 patients who underwent PPV for VH associated with BRVO and who were followed up for at least 12 months. Preoperative best-corrected visual acuity (BCVA), surgical intervention, final BCVA, and central foveal thickness (CFT) were evaluated using optical coherence tomography. We proposed a system to grade BRVO with VH from Grade I to Grade III with increasing severity: Grade I,pure persistent VH; Grade II,VH with epiretinal membrane (EM) (Grade IIa,VH with EM without macular involvement; Grade IIb,VH with EM with macular involvement); and Grade III,VH with tractive retinal detachment. Different surgical methods were appliedaccording to the different retinal conditions. Results BCVA significantly improved at final follow-up in all groups. There was no significant difference among the four groups in terms of preoperative BCVA, final BCVA,CFT,or the number of patients whose macular edema recurred after surgery (p>0.05), but there was a significant difference in vision improvement(p<0.05). Vision improvement in the Grade IIb group was significantly worse than in the Grade I group(p=0.006) and in the Grade IIa group(p=0.046). The percentage of patients in the Grade I, Grade IIa, Grade IIb, and Grade III groups needing further laser treatment after surgery was 0%, 8.3%, 16.3%, and 23.5%, respectively (p<0.05). Conclusion We proposed a new grading system for BRVO treated with PPV. Vitrectomy is a safe and effective treatment for BRVO with VH. Visual acuity improvement was significantly worse when the EM had macular involvement (Grade IIb).

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Classification of good visual acuity over time in patients with branch retinal vein occlusion with macular edema using support vector machine

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-021-05455-y ◽

2021 ◽

Author(s):

Yoshitsugu Matsui ◽

Kazuya Imamura ◽

Mihiro Ooka ◽

Shinichiro Chujo ◽

Yoko Mase ◽

...

Keyword(s):

Support Vector Machine ◽

Visual Acuity ◽

Macular Edema ◽

Retinal Vein Occlusion ◽

Branch Retinal Vein Occlusion ◽

Support Vector ◽

Good Visual Acuity ◽

Vein Occlusion ◽

Over Time

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The Use of Inner Retinectomy to Relieve Inner Retinal Foreshortening Causing Retinal Detachment in the Setting of Branch Retinal Vein Occlusion

Case Reports in Ophthalmological Medicine ◽

10.1155/2020/8853425 ◽

2020 ◽

Vol 2020 ◽

pp. 1-5

Author(s):

Katsuya Yagisawa ◽

Takayuki Baba ◽

Tomomi Kaiho ◽

Hirotaka Yokouchi ◽

Shuichi Yamamoto

Keyword(s):

Visual Acuity ◽

Retinal Detachment ◽

Retinal Vein Occlusion ◽

Branch Retinal Vein Occlusion ◽

Silicone Oil ◽

Internal Limiting Membrane ◽

Japanese Woman ◽

Vein Occlusion ◽

Initial Surgery ◽

Old Japanese

A 61-year-old Japanese woman presented with impairment of her left vision due to macular schisis secondary to branch retinal vein occlusion. Her left vision was 20/50, and schisis was observed inferotemporally. She underwent phacoemulsification and aspiration, implantation of the intraocular lens, and removal of the epiretinal membrane and internal limiting membrane. Her visual acuity stabilized ~20/50 for two and a half years after the initial surgery. However, she developed macula-involving retinal detachment, and her visual acuity declined to counting fingers. She underwent pars plana vitrectomy and removal of the residual vitreous cortex together with the inner retina within the area of vein occlusion. After the removal of silicone oil and the addition of an encircling buckle, the retina remained attached and visual acuity improved to 20/60 at one year after the final surgery. The combination of rhegmatogenous and tractional detachment in the area of schisis was suspected, and vitrectomy with inner retinectomy was effective.

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Visual acuity and foveal thickness after vitrectomy for macular edema associated with branch retinal vein occlusion: a case series

BMC Ophthalmology ◽

10.1186/1471-2415-10-11 ◽

2010 ◽

Vol 10 (1) ◽

Cited By ~ 9

Author(s):

Hidetaka Noma ◽

Hideharu Funatsu ◽

Tatsuya Mimura ◽

Shuichiro Eguchi ◽

Katsunori Shimada

Keyword(s):

Visual Acuity ◽

Macular Edema ◽

Retinal Vein Occlusion ◽

Branch Retinal Vein Occlusion ◽

Case Series ◽

Foveal Thickness ◽

Vein Occlusion

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Subthreshold Micropulse Photocoagulation for Persistent Macular Edema Secondary to Branch Retinal Vein Occlusion including Best-Corrected Visual Acuity Greater Than 20/40

Journal of Ophthalmology ◽

10.1155/2014/251257 ◽

2014 ◽

Vol 2014 ◽

pp. 1-10 ◽

Cited By ~ 16

Author(s):

Keiji Inagaki ◽

Kishiko Ohkoshi ◽

Sachiko Ohde ◽

Gautam A. Deshpande ◽

Nobuyuki Ebihara ◽

...

Keyword(s):

Visual Acuity ◽

Macular Edema ◽

Retinal Vein Occlusion ◽

Branch Retinal Vein Occlusion ◽

Disease Onset ◽

Vein Occlusion ◽

Corrected Visual Acuity ◽

Group I ◽

Group Ii ◽

Best Corrected Visual Acuity

To assess the efficacy of subthreshold micropulse diode laser photocoagulation (SMDLP) for persistent macular edema secondary to branch retinal vein occlusion (BRVO), including best-corrected visual acuity (BCVA) > 20/40, thirty-two patients (32 eyes) with macular edema secondary to BRVO were treated by SMDLP. After disease onset, all patients had been followed for at least 6 months prior to treatment. Baseline Snellen visual acuity was used to categorize the eyes as BCVA ≤ 20/40 (Group I) or BCVA > 20/40 (Group II). Main outcome measures were reduction in central macular thickness (CMT) in optical coherence tomography (OCT) and BCVA at 6 months. In the total subject-pool at 6 months, BCVA had not changed significantly but CMT was significantly reduced. Group I exhibited no significant change in CMT at 3 months but exhibited significant reductions at 6 and 12 months. Group II exhibited a marginally significant reduction in CMT at 3 months and a significant reduction at 6 months. In patients with persistent macular edema secondary to BRVO, SMDLP appears to control macular edema with minimal retinal damage. Our findings suggest that SMDLP is an effective treatment method for macular edema in BRVO patients with BCVA > 20/40.

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Peripheral Fluorescein Angiographic Findings in Fellow Eyes of Patients with Branch Retinal Vein Occlusion

International Journal of Inflammation ◽

10.1155/2013/464127 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4 ◽

Cited By ~ 11

Author(s):

Irena Tsui ◽

Asima Bajwa ◽

Valentina Franco-Cardenas ◽

Carolyn K. Pan ◽

Hanna Y. Kim ◽

...

Keyword(s):

Retinal Vein Occlusion ◽

Branch Retinal Vein Occlusion ◽

Wide Field ◽

Imaging Device ◽

Fellow Eye ◽

Vein Occlusion ◽

Inflammatory Changes ◽

Angiographic Findings ◽

Fluorescein Angiographic ◽

Fellow Eyes

Introduction. Branch retinal vein occlusion (BRVO) is a common retinal vascular condition that results in intraocular inflammatory changes. Ultra wide field fluorescein angiography (UWFFA) is a retinal imaging device that can capture peripheral retinal findings. The purpose of this study was to look for peripheral findings in the fellow eye of patients with BRVO using UWFFA.Methods. Retrospective imaging review of patients diagnosed with BRVO that had both eyes imaged with UWFFA. Images were graded for peripheral findings in other quadrants of the same eye as well as in all quadrants of the fellow eye.Results. Of 81 patients, 14 (17%) patients had late vascular leakage in a quadrant other than the BRVO distribution. Five (6%) findings were in the same eye, 8 (10%) findings were in the fellow eye, and 1 (1%) finding was in both the same eye and the fellow eye. Of these 14 patients, 11 (80%) patients had hypertension.Conclusion. Late peripheral retinal leakage in the fellow eye of patients with BRVO was detected in this cohort of patients with UWFFA. This novel finding may represent underlying systemic inflammation, hypertension, or bilateral BRVOs.

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Spectral domain optical coherence tomography (SD OCT) pattern of macular edema and visual acuity in recent-onset branch retinal vein occlusion (BRVO) in a tertiary hospital

Journal of Kathmandu Medical College ◽

10.3126/jkmc.v7i3.22676 ◽

2018 ◽

Vol 7 (3) ◽

pp. 89-93

Author(s):

Kiran Shakya ◽

Ram Prasad Pokhrel ◽

Om Krishna Malla

Keyword(s):

Visual Acuity ◽

Macular Edema ◽

Retinal Vein Occlusion ◽

Branch Retinal Vein Occlusion ◽

Spectral Domain ◽

Hypertensive Group ◽

Vein Occlusion ◽

Corrected Visual Acuity ◽

Stage 1 ◽

Best Corrected Visual Acuity

Background: Macular edema is the common sight-threatening condition following branch retinal vein occlusion. Objective: To find spectral domain optical coherence tomography characteristics of macular involvement and visual acuity in the patients with branch retinal vein occlusion Methodology: This is a cross-sectional study; consecutive new cases of branch retinal vein occlusion diagnosed at the ophthalmology department of Kathmandu Medical College, Kathmandu were carried out from November 2016 to October 2017. All subjects were divided three groups with normotensive/controlled hypertension, stage 1 hypertension (systolic pressure >140 mm Hg or diastolic pressure >90mm Hg) and Stage 2 hypertension (systolic pressure >160 mm Hg or diastolic pressure >100 mm Hg).The macular edema was evaluated by taking best corrected visual acuity and spectral domain optical coherence tomography for measurement of central foveal thickness. Results: Forty patients with forty eyes were enrolled. Mean age was 58.5 years SD ± 9.98 years. Stage 1 and stage 2 hypertensive groups had significantly worse best corrected visual acuity and more thickness of central foveal thickness than normotensive/controlled group (p<0.001). The best corrected visual acuity and central foveal thickness were successively worse among normotensive group, stage 1 hypertensive group and stage 2 hypertensive group (between normotensive/controlled group and stage 1 hypertensive group, p = 0.032 and 0.002 respectively and between stage I hypertensive group and stage 2 hypertensive group, p= 0.013 and 0.09 respectively). Conclusion: Control of hypertension could be a main contributing measure to lower incidence of branch retinal vein occlusion and the severity of macular edema.

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