scholarly journals Non-invasive analysis of bovine embryo metabolites during in vitro embryo culture using nuclear magnetic resonance

2016 ◽  
Vol 3 (4) ◽  
pp. 538-551
Author(s):  
Marcello Rubessa ◽  
◽  
Andrea Ambrosi ◽  
Dianelys Gonzalez-Pena ◽  
Kathryn M. Polkoff ◽  
...  
Medic ro ◽  
2021 ◽  
Vol 4 (1) ◽  
pp. 29-34
Author(s):  
Micu Maria-Andreea ◽  
Emese Orban

Nuclear magnetic resonance (NMR) is a complex physical process based on the interaction of protons in an electro­mag­ne­tic field, the most well-known and widespread ap­pli­cation in medical-clinical and medical-surgical field being nuclear magnetic resonance imaging. Considering the interdependent relationship between research in scien­ti­fic fields that are closely related to medicine and the me­di­cal world, it is particularly important to be aware of the existence of other applications of the physical process men­tioned before: diffusionometry, relaxometry and MRI spectroscopy. These are well-known and studied research entities, but their applicability in the clinical diagnostic pro­cess is still limited, despite the huge potential to provide a much broader and more detailed perspective on various biological tissues in vitro, but even in vivo. We want to re­view the evolution of nuclear magnetic resonance to­mo­gra­phy or imaging, which has gone from being a Nobel Prize-winning idea to one of the most widespread and useful methods of non-invasive and non-irradiating me­di­cal imaging, but especially an example of the feasi­bi­li­ty of diffusionometry, relaxometry, respectively MRI spec­tro­scopy in a medical setting, through global studies on their po­ten­tial diagnosis in areas such as oncology, neurology, en­do­cri­no­logy and others.  


Molbank ◽  
10.3390/m1213 ◽  
2021 ◽  
Vol 2021 (2) ◽  
pp. M1213
Author(s):  
Paolo Coghi ◽  
Jerome P. L. Ng ◽  
Ali Adnan Nasim ◽  
Vincent Kam Wai Wong

The 1,2,3-triazole is a well-known biologically active pharmacophore constructed by the copper-catalyzed azide–alkyne cycloaddition. We herein reported the synthesis of 4-amino-7-chloro-based [1,2,3]-triazole hybrids via Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of 4-azido-7-chloroquinoline with an alkyne derivative of acetaminophen. The compound was fully characterized by Fourier-transform infrared (FTIR), proton nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR), heteronuclear single quantum coherence (HSQC), ultraviolet (UV) and high-resolution mass spectroscopies (HRMS). This compound was screened in vitro with different normal and cancer cell lines. The drug likeness of the compound was also investigated by predicting its pharmacokinetic properties.


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