scholarly journals Independent and joint associations of grip strength and adiposity with all-cause and cardiovascular disease mortality in 403,199 adults: the UK Biobank study

2017 ◽  
pp. ajcn156851 ◽  
Author(s):  
Youngwon Kim ◽  
Katrien Wijndaele ◽  
Duck-chul Lee ◽  
Stephen J Sharp ◽  
Nick Wareham ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Grip Strength ◽  
Uk Biobank ◽  
Cardiovascular Disease Mortality ◽  
Disease Mortality ◽  
The Uk ◽  
Joint Associations

OP12 Total Fruit Intake and Cardiovascular Disease Mortality in The UK Women’s Cohort Study (UKWCS)

2014 ◽  
Vol 68 (Suppl 1) ◽  
pp. A9.2-A9
Author(s):  
HT Lai ◽  
DE Threapleton ◽  
AJ Day ◽  
G Williamson ◽  
VJ Burley ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Study ◽  
Fruit Intake ◽  
Cardiovascular Disease Mortality ◽  
Disease Mortality ◽  
The Uk

scholarly journals Dietary fibre and cardiovascular disease mortality in the UK Women’s Cohort Study

2013 ◽  
Vol 28 (4) ◽  
pp. 335-346 ◽  
Author(s):  
Diane E. Threapleton ◽  
Darren C. Greenwood ◽  
Victoria J. Burley ◽  
Maryam Aldwairji ◽  
Janet E. Cade
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Study ◽  
Dietary Fibre ◽  
Cardiovascular Disease Mortality ◽  
Disease Mortality ◽  
The Uk

scholarly journals Joint associations of smoking and television viewing time on cancer and cardiovascular disease mortality

2017 ◽  
Vol 140 (7) ◽  
pp. 1538-1544 ◽  
Author(s):  
Megan S. Grace ◽  
Brigid M. Lynch ◽  
Francis Dillon ◽  
Elizabeth L.M. Barr ◽  
Neville Owen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Television Viewing ◽  
Viewing Time ◽  
Cardiovascular Disease Mortality ◽  
Disease Mortality ◽  
Joint Associations

scholarly journals Reply to: Joint associations of smoking and television viewing time on cancer and cardiovascular disease mortality-Methodological issues

2017 ◽  
Vol 140 (9) ◽  
pp. 2170-2171 ◽  
Author(s):  
Megan S. Grace ◽  
Brigid M. Lynch ◽  
Francis Dillon ◽  
Elizabeth L. M. Barr ◽  
Neville Owen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Television Viewing ◽  
Viewing Time ◽  
Methodological Issues ◽  
Cardiovascular Disease Mortality ◽  
Disease Mortality ◽  
Joint Associations

scholarly journals Fitness, Physical Activity, and Cardiovascular Disease: Longitudinal and Genetic Analyses in the UK Biobank Study

2017 ◽  
Author(s):  
Emmi Tikkanen ◽  
Stefan Gustafsson ◽  
Erik Ingelsson
Keyword(s):  
Physical Activity ◽  
Cardiovascular Disease ◽  
Grip Strength ◽  
Cardiorespiratory Fitness ◽  
Genetic Risk ◽  
Cardiovascular Events ◽  
Large Scale ◽  
Mendelian Randomization ◽  
Uk Biobank ◽  
The Uk

AbstractBackgroundExercise is inversely related with cardiovascular disease (CVD), but large-scale studies of incident CVD events are lacking. Moreover, little is known about genetic determinants of fitness and physical activity, and modifiable effects of exercise in individuals with elevated genetic risk of CVD. Finally, causal analyses of exercise traits are limited.MethodsWe estimated associations of grip strength, physical activity, and cardiorespiratory fitness with CVD and all-cause death in up to 502,635 individuals from the UK Biobank. We also examined these associations in individuals with different genetic burden on coronary heart disease (CHD) and atrial fibrillation (AF). Finally, we performed genome-wide association study (GWAS) of grip strength and physical activity, as well as Mendelian randomization analysis to assess the causal role of grip strength in CHD.FindingsGrip strength, physical activity, and cardiorespiratory fitness showed strong inverse associations with incident cardiovascular events and all-cause death (for composite CVD; HR, 0.78, 95% CI, 0.77-0.80; HR, 0.94, 95% CI, 0.93-0.95, and HR, 0.67, 95% CI, 0.63-0.71, per SD change, respectively). We observed stronger associations of grip strength with CHD and AF for individuals in the lowest tertile of genetic risk (Pinteraction = 0.006, Pinteraction = 0.03, respectively), but the inverse associations were present in each category of genetic risk. We report 27 novel genetic loci associated with grip strength and 2 loci with physical activity, with the strongest associations in FTO (rs56094641, P=3.8×10-24) and SMIM2 (rs9316077, P=1.4×10-8), respectively. By use of Mendelian randomization, we provide evidence that grip strength is causally related to CHD.InterpretationMaintaining physical strength is likely to prevent future cardiovascular events, also in individuals with elevated genetic risk for CVD.FundingNational Institutes of Health (1 R01 HL135313-01), Knut and Alice Wallenberg Foundation (2013.0126), and the Finnish Cultural Foundation.

scholarly journals Fruit intake and cardiovascular disease mortality in the UK Women’s Cohort Study

2015 ◽  
Vol 30 (9) ◽  
pp. 1035-1048 ◽  
Author(s):  
Heidi Tsz Mung Lai ◽  
Diane Erin Threapleton ◽  
Andrea Jill Day ◽  
Gary Williamson ◽  
Janet Elizabeth Cade ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Study ◽  
Fruit Intake ◽  
Cardiovascular Disease Mortality ◽  
Disease Mortality ◽  
The Uk

Low birthweight is associated with poorer limb muscle mass and grip strength in middle age: findings from the UK Biobank Imaging Enhancement

2019 ◽  
Author(s):  
Elizabeth Curtis ◽  
Justin Liu ◽  
Kate Ward ◽  
Karen Jameson ◽  
Zahra Raisi-Estabragh ◽  
...  
Keyword(s):  
Grip Strength ◽  
Muscle Mass ◽  
Low Birthweight ◽  
Middle Age ◽  
Limb Muscle ◽  
Uk Biobank ◽  
The Uk
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