Phenanthroindolizidine Alkaloids and Their Cytotoxicity from the Leaves of Ficus septica

Heterocycles ◽  
2002 ◽  
Vol 57 (12) ◽  
pp. 2401 ◽  
Author(s):  
Pei-Lin Wu ◽  
K. V. Rao ◽  
Chia-Hao Su ◽  
Cheng-Sheng Kuoh ◽  
Tian-Shung Wu
Keyword(s):  
Phenanthroindolizidine Alkaloids

scholarly journals Cytotoxic and Anti-HIV Phenanthroindolizidine Alkaloids from Cryptocarya chinensis†

2012 ◽  
Vol 7 (6) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Tian-Shung Wu ◽  
Chung-Ren Su ◽  
Kuo-Hsiung Lee
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Optical Rotation ◽  
Ethanol Extract ◽  
Cancer Cell Lines ◽  
Spectroscopic Methods ◽  
Bioassay Guided Fractionation ◽  
Phenanthroindolizidine Alkaloids ◽  
Anti Hiv

Bioassay-guided fractionation of the cytotoxic ethanol extract of Cryptocarya chinensis has led to the isolation of 11 compounds, including two phenanthroindolizidine alkaloids [(-)-antofine (1) and dehydroantofine (2)], five pavine alkaloids (3-7), and four proaporphine alkaloids (8-11). The structures of the isolated compounds were determined by means of NMR spectroscopic methods, and supported by HRMS and optical rotation data. Compounds 1 and 2 showed cytotoxic activity against four cancer cell lines, L1210, P388, A549, and HCT-8, with 1 being the most potent against A549 and HCT-8 with EC50 values of 0.002 and 0.001 μg/mL, respectively. In addition, 2 is first reported to exhibit significant anti-HIV activity.

Structure–activity studies of phenanthroindolizidine alkaloids as potential antitumor agents

2007 ◽  
Vol 17 (15) ◽  
pp. 4338-4342 ◽  
Author(s):  
Wenli Gao ◽  
Scott Bussom ◽  
Susan P. Grill ◽  
Elizabeth A. Gullen ◽  
You-Cai Hu ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Structure Activity ◽  
Phenanthroindolizidine Alkaloids ◽  
Potential Antitumor

Iron(III) chloride-based mild synthesis of phenanthrene and its application to total synthesis of phenanthroindolizidine alkaloids

Tetrahedron ◽  
2008 ◽  
Vol 64 (32) ◽  
pp. 7504-7510 ◽  
Author(s):  
Kai-Liang Wang ◽  
Mao-Yun Lü ◽  
Qing-Min Wang ◽  
Run-Qiu Huang
Keyword(s):  
Total Synthesis ◽  
Phenanthroindolizidine Alkaloids
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