scholarly journals Effect of doxycycline doped bone substitute on vertical bone augmentation on rat calvaria

2019 ◽  
Vol 38 (2) ◽  
pp. 211-217
Author(s):  
Peng ZHANG ◽  
Lin DING ◽  
Shohei KASUGAI
Keyword(s):  
Bone Substitute ◽  
Bone Augmentation ◽  
Rat Calvaria

scholarly journals Effect of a chitosan sponge impregnated with platelet-derived growth factor on bone augmentation beyond the skeletal envelope in rat calvaria

2014 ◽  
Vol 56 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Noriko Tsuchiya ◽  
Shuichi Sato ◽  
Risa Kigami ◽  
Eisuke Kawano ◽  
Masatoshi Takane ◽  
...  
Keyword(s):  
Growth Factor ◽  
Platelet Derived Growth Factor ◽  
Bone Augmentation ◽  
Rat Calvaria

scholarly journals Bone repair induced by different bone graft substitutes in critical-sized defects in rat calvaria

2019 ◽  
Vol 48 ◽  
Author(s):  
Mauricio Andrés Tinajero ARONI ◽  
Paulo Firmino da COSTA NETO ◽  
Guilherme José Pimentel Lopes de OLIVEIRA ◽  
Rosemary Adriana Chiérici MARCANTONIO ◽  
Elcio MARCANTONIO JUNIOR
Keyword(s):  
Bone Graft ◽  
Bone Substitute ◽  
Bone Repair ◽  
Bone Substitutes ◽  
Autogenous Bone ◽  
Bovine Bone ◽  
Rat Calvaria ◽  
Mineralized Tissues ◽  
Bone Graft Substitutes ◽  
Biphasic Ceramic

Abstract Introduction The use of bone substitutes in grafting procedures as an alternative of the use of autogenous bone graft has been indicated, however, the direct comparison between these biomaterials has been little explored. Objective To evaluate the effect of different osteoconductive bone substitutes on the bone repair in critical-sized defects (CSDs) in rat calvaria. Material and method One CSD with an 8 mm diameter was made in each of the 40 rats used in this study. The animals were randomly allocated into 5 groups (n=8), according to the type of bone substitute used to fill the CSD: COA (Coagulum); AUT (autogenous bone); DBB (deproteinized bovine bone graft); HA/TCP (biphasic ceramic composed of hydroxyapatite and β-phosphate tricalcium); and TCP (β-phosphate tricalcium). A microtomographic analysis was performed to evaluate the remaining defect linear length (DLL) of the CSD and the volume of the mineralized tissues (MT) within the CSD at 3, 7, 15 and 30 days after the surgical procedure. In addition, a histometric analysis was performed to evaluate the composition of the repaired bone tissue (% Bone and % Biomaterial) at the 30-day period. Result It was shown that the COA had the lowest DLL and MT within the CSD. In addition, the COA presented the highest % of bone in CSD. The DBB had a higher MT and a higher % of bone substitute particles in the CSD than the AUT and TCP groups. The DBB and AUT groups presented higher % of bone in the CSD than the TCP group. Conclusion The use of the DBB promoted a better pattern of bone volume gain and formation compared to TCP and HA / TCP but was biologically inferior to the AUT.

scholarly journals Melatonin enhances vertical bone augmentation in rat calvaria secluded spaces

2016 ◽  
pp. e122-e126 ◽  
Author(s):  
H Shino ◽  
A Hasuike ◽  
Y Arai ◽  
M Honda ◽  
K Isokawa ◽  
...  
Keyword(s):  
Bone Augmentation ◽  
Rat Calvaria

Osteoclasts may contribute bone substitute materials remodeling and bone formation in bone augmentation

2020 ◽  
Vol 135 ◽  
pp. 109438
Author(s):  
Lin-hai He ◽  
Zhi-Yong Zhang ◽  
Xiao Zhang ◽  
E. Xiao ◽  
Meng Liu ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Substitute ◽  
Bone Augmentation ◽  
Bone Substitute Materials ◽  
Substitute Materials

scholarly journals Bioactivity Evaluation of Biphasic Hydroxyapatite Bone Substitutes Immersed and Grown with Supersaturated Calcium Phosphate Solution

Materials ◽  
2021 ◽  
Vol 14 (18) ◽  
pp. 5143
Author(s):  
Yusuke Yamaguchi ◽  
Tomonori Matsuno ◽  
Atsuko Miyazawa ◽  
Yoshiya Hashimoto ◽  
Takafumi Satomi
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Bone Substitute ◽  
The Body ◽  
Phosphate Solution ◽  
Bone Augmentation ◽  
Bone Substitute Materials ◽  
Low Crystalline ◽  
Substitute Materials ◽  
Implant Treatment

Recently, the frequency of use of bone substitute materials for the purpose of bone augmentation has increased in implant treatment, but bone formation with bone substitute materials alone is limited. Calcification of bone in the body progresses as Ca2+, H2PO4-, and HPO42- in the body form hydroxyapatite (HA) crystals. In this study, therefore, we prepared a biphasic bone substitute with biological activity to promote bone formation by inducing precipitation and growth of HA crystals on the surface of a bone substitute and evaluated it. Biphasic bone substitute granules were prepared by immersing HA granules in a supersaturated calcium phosphate solution prepared by mixing five medical infusion solutions, the precipitate was analyzed, and the biological activities of biphasic HA granules were evaluated in vitro and in vivo. As a result, the precipitated calcium phosphate crystals were identified as low crystalline HA. On the surface of the HA granules, low-crystalline HA grew markedly as needle-shaped crystals and significantly promoted cell proliferation and bone differentiation. In animal experiments, biphasic HA granules had a significantly higher bone mineral density, new bone volume ratio, and new bone area ratio. Therefore, it suggests that biphasic hydroxyapatite is a useful bone substitute for bone augmentation in dental implant treatment.

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