Using live, synchronous time effectively in an instructor-led e-learning course requires a clear understanding of the dynamics of real-time, live interactivity. Synchronous interactivity enables live learning, demonstrations, collaborations, lab simulations, human-driven simulations, desktop simulations, live multi-data-stream events, and plenty of valuable learning and training. These may include webinars, online conventions, chat sessions, interactive television, and interactive lectures in CTE. These synchronous events may be non-human-facilitated or human-facilitated. To maximize synchronous time requires pedagogical preparation and the training of participants, setting the pace, troubleshooting technological challenges, and striving to create accessibility pre-, during- and post-event. This chapter will address some strategies for using live sessions in career and technical education to optimize the synergies of real-time.