Lens and Anterior Uvea

2022 ◽  
pp. 359-392
Keyword(s):  
Macular Edema ◽  
Anterior Uveitis ◽  
Clinical Signs ◽  
Inflammatory Cells ◽  
Clinical Findings ◽  
Eye Drops ◽  
Systemic Diseases ◽  
Intravitreal Triamcinolone ◽  
Keratic Precipitates ◽  
Intravitreal Triamcinolone Injection

This chapter illustrates photos of clinical signs seen in uveitis and interesting cases of lens pathologies. Anterior uveitis is the inflammation of the iris and the ciliary body. Anterior uveitis can be idiopathic, isolated, or associated with systemic diseases. The clinical findings observed in anterior uveitis include keratic precipitates, inflammatory cells and flare in anterior chamber, hypopyon, rarely hyphema, miosis, iris nodules and atrophy, synechiae, and band keratopathy in chronic cases (shown in corneal degenerations chapter). The inflammation in anterior uveitis is almost always immune. Treatment includes steroid eye drops, cycloplegic drops, sub-Tenon steroid injections when cystoid macular edema is present. Chronic macular edema can be treated with intravitreal Triamcinolone injection and Dexamethasone implants. In cases of refractory anterior uveitis or associated immune systemic diseases, immunomodulatory treatment or biologic agents are prescribed.

scholarly journals Epstein-Barr virus uveitis after intravitreal triamcinolone injection

2021 ◽  
Vol 17 (4) ◽  
pp. 416-419
Author(s):  
Jessica Ong ◽  
Josephine Richards
Keyword(s):  
Macular Edema ◽  
Epstein Barr Virus ◽  
Intravitreal Bevacizumab ◽  
High Dose ◽  
Intravitreal Triamcinolone ◽  
Barr Virus ◽  
Triamcinolone Injection ◽  
Intravitreal Triamcinolone Injection ◽  
Epstein Barr ◽  
Acute Infectious Mononucleosis

Purpose: To report a case of Epstein-Barr virus (EBV) uveitis after intravitreal triamcinolone injection. Methods: Observational case report. Results: A 66-year-old male presented with bilateral intermediate uveitis, left macular branch retinal vein occlusion, and left macular edema 3 months following acute infectious mononucleosis. He received systemic prednisolone, methotrexate, and intravitreal bevacizumab with partial response. Intravitreal triamcinolone was given for recurrent macular edema, which led to the development of severe panuveitis with positive EBV PCR in aqueous humour. This was successfully treated with high-dose systemic valaciclovir and topical prednisolone. Conclusion: Non-infectious uveitis may become infectious following intravitreal steroid administration triggering intraocular viral replication. Intraocular fluid should be tested in cases which are suspicious for infection and EBV should be considered a differential diagnosis, particularly if PCR is negative for more common viral etiologies.

Serous Macular Detachment as a Predictor of Resolution of Macular Edema with Intravitreal Triamcinolone Injection

2009 ◽  
Vol 40 (2) ◽  
pp. 115-119 ◽  
Author(s):  
Dhananjay Shukla ◽  
Umesh Chandra Behera ◽  
Somnath Chakraborty ◽  
Rajendran Mahalakshmi ◽  
Noela Marie Prasad
Keyword(s):  
Macular Edema ◽  
Serous Macular Detachment ◽  
Intravitreal Triamcinolone ◽  
Macular Detachment ◽  
Triamcinolone Injection ◽  
Intravitreal Triamcinolone Injection

INTRAVITREAL TRIAMCINOLONE INJECTION FOR TREATMENT OF MACULAR EDEMA SECONDARY TO BRANCH RETINAL VEIN OCCLUSION

Retina ◽  
2005 ◽  
Vol 25 (7) ◽  
pp. 851-855 ◽  
Author(s):  
OSMAN ÇEKİÇ ◽  
STANLEY CHANG ◽  
JOSEPH J. TSENG ◽  
GAETANO R. BARILE ◽  
LUCIAN V. DEL PRIORE ◽  
...  
Keyword(s):  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Intravitreal Triamcinolone ◽  
Vein Occlusion ◽  
Triamcinolone Injection ◽  
Intravitreal Triamcinolone Injection

scholarly journals In vivo Confocal Microscopy in Differentiating Ipilimumab-Induced Anterior Uveitis from Metastatic Uveal Melanoma

2016 ◽  
Vol 7 (3) ◽  
pp. 404-409 ◽  
Author(s):  
Hayyam Kiratli ◽  
Mehmet C. Mocan ◽  
Murat İrkeç
Keyword(s):  
Visual Acuity ◽  
Confocal Microscopy ◽  
Uveal Melanoma ◽  
Anterior Uveitis ◽  
Choroidal Melanoma ◽  
Inflammatory Cells ◽  
In Vivo Confocal Microscopy ◽  
Keratic Precipitates ◽  
Metastatic Process

This report aims to describe the facilitating role of in vivo confocal microscopy in differentiating inflammatory cells from a metastatic process in a patient with uveal melanoma and multiple systemic metastases who developed anterior uveitis while under ipilimumab treatment. A 43-year-old woman developed systemic metastases 11 months after treatment of amelanotic choroidal melanoma in her right eye with 30 Gy fractionated stereotactic radiotherapy. She first received temozolomide and then 4 cycles of ipilimumab 3 mg/kg/day. After the third cycle, severe anterior uveitis with coarse pigment clumps on the lens was seen in the left eye. Her left visual acuity declined from 20/20 to 20/80. Confocal microscopy revealed globular keratic precipitates with hyperreflective inclusions and endothelial blebs all suggestive of granulomatous uveitis. The uveitic reaction subsided after a 3-week course of topical corticosteroids, and her visual acuity was 20/20 again. Although uveal melanoma metastatic to the intraocular structures of the fellow eye is exceedingly rare and metastasis masquerading uveitis without any identifiable uveal lesion is even more unusual, it was still mandatory to rule out this distant possibility in our particular patient who already had widespread systemic metastases. Confocal microscopy was a useful complementary tool by identifying the inflammatory features of the keratic precipitates.

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