scholarly journals Epstein-Barr virus uveitis after intravitreal triamcinolone injection

2021 ◽  
Vol 17 (4) ◽  
pp. 416-419
Author(s):  
Jessica Ong ◽  
Josephine Richards
Keyword(s):  
Macular Edema ◽  
Epstein Barr Virus ◽  
Intravitreal Bevacizumab ◽  
High Dose ◽  
Intravitreal Triamcinolone ◽  
Barr Virus ◽  
Triamcinolone Injection ◽  
Intravitreal Triamcinolone Injection ◽  
Epstein Barr ◽  
Acute Infectious Mononucleosis

Purpose: To report a case of Epstein-Barr virus (EBV) uveitis after intravitreal triamcinolone injection. Methods: Observational case report. Results: A 66-year-old male presented with bilateral intermediate uveitis, left macular branch retinal vein occlusion, and left macular edema 3 months following acute infectious mononucleosis. He received systemic prednisolone, methotrexate, and intravitreal bevacizumab with partial response. Intravitreal triamcinolone was given for recurrent macular edema, which led to the development of severe panuveitis with positive EBV PCR in aqueous humour. This was successfully treated with high-dose systemic valaciclovir and topical prednisolone. Conclusion: Non-infectious uveitis may become infectious following intravitreal steroid administration triggering intraocular viral replication. Intraocular fluid should be tested in cases which are suspicious for infection and EBV should be considered a differential diagnosis, particularly if PCR is negative for more common viral etiologies.

Effect of high-dose vitamin D3 supplementation on antibody responses against Epstein–Barr virus in relapsing-remitting multiple sclerosis

2016 ◽  
Vol 23 (3) ◽  
pp. 395-402 ◽  
Author(s):  
Egil Røsjø ◽  
Andreas Lossius ◽  
Nada Abdelmagid ◽  
Jonas C Lindstrøm ◽  
Margitta T Kampman ◽  
...  
Keyword(s):  
Vitamin D ◽  
Epstein Barr Virus ◽  
High Dose ◽  
Oral Vitamin ◽  
Barr Virus ◽  
Relapsing Remitting ◽  
Dose Oral ◽  
Epstein Barr ◽  
Antibody Levels ◽  
Relapsing Remitting Multiple Sclerosis

Background: Elevated antibody levels against Epstein–Barr virus (EBV) and a poor vitamin D status are environmental factors that may interact in relapsing-remitting multiple sclerosis (RRMS) aetiology. Objectives: To examine effects of high-dose oral vitamin D3 supplementation on antibody levels against EBV nuclear antigen 1 (EBNA1) in RRMS. Methods: Serum 25-hydroxyvitamin D3 (25(OH)D) and immunoglobulin G antibody levels against EBNA1 (whole protein and amino acid 385–420 fragment), EBV viral capsid antigen (VCA), cytomegalovirus (CMV) and varicella zoster virus (VZV) were measured in 68 RRMS patients enrolled in a 96-week randomised double-blinded placebo-controlled clinical trial of oral vitamin D3 supplementation (20,000 IU/week) (NCT00785473). Results: The mean 25(OH)D level more than doubled in the vitamin D group and was significantly higher than in the placebo group at study conclusion (123.2 versus 61.8 nmol/L, p < 0.001). Compared to the placebo group, both anti-EBNA1 protein and fragment antibody levels decreased in the vitamin D group from baseline to week 48 ( p = 0.038 and p = 0.004, respectively), but not from baseline to week 96. Vitamin D3 supplementation did not affect antibodies against VCA, CMV or VZV. Conclusion: The results indicate that high-dose oral vitamin D3 supplementation can affect humoral immune responses against the latent EBV antigen EBNA1 in RRMS.

scholarly journals Erratam: Epstein-Barr virus BZLF1 gene promoter variants in pediatric patients with acute infectious mononucleosis. Its comparison with pediatric lymphomas

2012 ◽  
Vol 84 (10) ◽  
pp. 1697-1697
Author(s):  
Mario Alejandro Lorenzetti ◽  
Marina Inés Gutiérrez ◽  
Jaime Altcheh ◽  
Guillermo Moscatelli ◽  
Samanta Moroni ◽  
...  
Keyword(s):  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Pediatric Patients ◽  
Gene Promoter ◽  
Barr Virus ◽  
Bzlf1 Gene ◽  
Epstein Barr ◽  
Acute Infectious Mononucleosis

Serous Macular Detachment as a Predictor of Resolution of Macular Edema with Intravitreal Triamcinolone Injection

2009 ◽  
Vol 40 (2) ◽  
pp. 115-119 ◽  
Author(s):  
Dhananjay Shukla ◽  
Umesh Chandra Behera ◽  
Somnath Chakraborty ◽  
Rajendran Mahalakshmi ◽  
Noela Marie Prasad
Keyword(s):  
Macular Edema ◽  
Serous Macular Detachment ◽  
Intravitreal Triamcinolone ◽  
Macular Detachment ◽  
Triamcinolone Injection ◽  
Intravitreal Triamcinolone Injection

Epstein–Barr virus-associated smooth muscle tumour mimicking bilateral vocal process granuloma

2007 ◽  
Vol 122 (1) ◽  
pp. 100-104 ◽  
Author(s):  
E C Gan ◽  
D P C Lau ◽  
K L Chuah
Keyword(s):  
Smooth Muscle ◽  
Epstein Barr Virus ◽  
English Literature ◽  
High Dose ◽  
Smooth Muscle Tumour ◽  
Barr Virus ◽  
Vocal Process ◽  
Epstein Barr ◽  
Laser Excision ◽  
End Stage

AbstractA case is presented of a 36-year-old Chinese woman with a renal transplant for end-stage renal failure due to Goodpasture's syndrome. She presented with a year's history of throat discomfort and acid regurgitation into her throat. Videolaryngoscopy revealed bilateral vocal process granuloma, presumed to be due to gastroesophageal reflux. A four-week course of high dose omeprazole was prescribed. On follow up a month later, the granulomas had enlarged, and laser excision was undertaken. Histological and immunohistochemical staining was consistent with Epstein–Barr virus-associated smooth muscle tumour. This is believed to be the first reported case in the English literature of such a tumour affecting the vocal process. The aim of this paper is to present the pathogenesis, clinical behaviour and treatment of Epstein–Barr virus-associated smooth muscle tumour, and to review the literature concerning the differential diagnosis of polypoid vocal process lesions.

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