Preparation of Poly(Lactic Acid) Composite Hollow Spheres with an Open Channel

Author(s):  
Hirotaka Maeda ◽  
Noriko Miura ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami
2005 ◽  
Vol 284-286 ◽  
pp. 301-304 ◽  
Author(s):  
Hirotaka Maeda ◽  
Noriko Miura ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami

Novel hollow spheres for bone fillers incorporating cells were prepared using composites consisting of poly(lactic acid) and calcium carbonates. An open channel of ~800 µm in diameter was easily formed using a chemical etching method to provide a pathway to the interior of the sphere. Cells could migrate through the open channel into the interior of the sphere. Bonelike apatite coating on the surface of the sphere was prepared by soaking in calcium chloride solution to supply excess Ca2+ ions on the surface and subsequently by soaking in simulated body fluid. The hollow spheres with an open channel may be one of the great potential candidates as novel bone fillers combined with a cell-delivery system.


2006 ◽  
Vol 309-311 ◽  
pp. 457-460 ◽  
Author(s):  
Noriko Miura ◽  
Hirotaka Maeda ◽  
Toshihiro Kasuga

Silica-doped poly(lactic acid) (PLA) composite hollow spheres containing calcium carbonates (Si-CCPC spheres) were prepared using aminopropyltriethoxysilane (APTES) for injectable bone fillers combined with a cell-delivery system. Si-CCPC spheres have a hollow spherical shape of ~1 mm in the external diameter and an open channel in the shell, which is selfformed. The channel size is about 500 *m in diameter. X-ray energy dispersive spectroscopy (EDS) analysis showed incorporation of silicon in Si-CCPC spheres. After soaking Si-CCPC spheres in simulated body fluid (SBF), hydroxycarbonate apatite formed on the Si-CCPC spheres. Inductively coupled plasma atomic emission spectroscopy (ICP-AES) showed that the Si4+ ion is released from Si-CCPC spheres in SBF.


2003 ◽  
Vol 254-256 ◽  
pp. 533-536 ◽  
Author(s):  
Hirotaka Maeda ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami

2011 ◽  
Vol 131 (5) ◽  
pp. 395-400 ◽  
Author(s):  
Toru Oi ◽  
Katsuyoshi Shinyama ◽  
Shigetaka Fujita

2014 ◽  
Vol 134 (4) ◽  
pp. 237-242
Author(s):  
Naru Matsugasaki ◽  
Katsuyoshi Shinyama ◽  
Shigetaka Fujita

2020 ◽  
Vol 62 (6) ◽  
pp. 732-743
Author(s):  
Chi-Hui Tsou ◽  
Jipeng Guo ◽  
Ji-Ang Lei ◽  
Manuel Reyes De Guzman ◽  
Maw-Cherng Suen
Keyword(s):  

Sign in / Sign up

Export Citation Format

Share Document