scholarly journals Solution Mediated Effect of Bioactive Glass in Poly (Lactic-Co-Glycolic Acid)- Bioactive Glass Composites on Osteogenesis of Marrow Stromal Cells

2005 ◽  
pp. 619-622
Author(s):  
Jun Yao ◽  
Shula Radin ◽  
Gwendolen Reilly ◽  
Phoebe S. Leboy ◽  
Paul Ducheyne
Keyword(s):  
Bioactive Glass ◽  
Stromal Cells ◽  
Glycolic Acid ◽  
Marrow Stromal Cells ◽  
Glass Composites

scholarly journals Solution Mediated Effect of Bioactive Glass in Poly (Lactic-Co-Glycolic Acid)- Bioactive Glass Composites on Osteogenesis of Marrow Stromal Cells

2005 ◽  
Vol 284-286 ◽  
pp. 619-622 ◽  
Author(s):  
Jun Yao ◽  
Shula Radin ◽  
Gwendolen Reilly ◽  
Phoebe S. Leboy ◽  
Paul Ducheyne
Keyword(s):  
Bioactive Glass ◽  
Stromal Cells ◽  
Glycolic Acid ◽  
Three Dimensional ◽  
Osteoblastic Differentiation ◽  
Marrow Stromal Cells ◽  
Dimensional Structure ◽  
Composite Scaffolds ◽  
Glass Composites ◽  
Osteogenic Effect

A previous study demonstrated that the incorporation of bioactive glass (BG) into poly (lactic-co-glycolic acid) (PLGA) can promote the osteoblastic differentiation of marrow stromal cells (MSC) on PLGA by forming a calcium phosphate rich layer on its surface. To further understand the mechanisms underlying the osteogenic effect of PLGA-BG composite scaffolds, we tested whether solution-mediated factors derived from composite scaffolds/hybrids can promote osteogenesis of marrow stromal cells. The dissolution product from PLGA-30%BG scaffold stimulated osteogenesis of MSC, as was confirmed by increased mRNA expression of osteoblastic markers such as osteocalcin (OCN), alkaline phosphatase (ALP), and bone sialoprotein (BSP). The three-dimensional structure of the scaffolds may contribute to the production of cell derived factors which promoted distant MSC differentiation. Thus PLGA-BG composites demonstrates significant potential as a bone replacement material.

Osteogenic effects of bioactive glass on bone marrow stromal cells

2005 ◽  
Vol 73A (1) ◽  
pp. 21-29 ◽  
Author(s):  
S. Radin ◽  
G. Reilly ◽  
G. Bhargave ◽  
P.S. Leboy ◽  
P. Ducheyne
Keyword(s):  
Bone Marrow ◽  
Bioactive Glass ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells

scholarly journals Influence of dissolution products of a novel Ca-enriched silicate bioactive glass-ceramic on VEGF release from bone marrow stromal cells

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Preethi Balasubramanian ◽  
Rainer Detsch ◽  
Leticia Esteban-Tejeda ◽  
Alina Grünewald ◽  
José S. Moya ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bioactive Glass ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Healing Process ◽  
Cell Activity ◽  
Marrow Stromal Cells ◽  
Ion Release ◽  
Vegf Release

AbstractThis study evaluated the influence of ionic dissolution products of a novel Ca-enriched silicate bioactive glass compared to commercial available hydroxyapaptite samples (Endobonr) on cell activity and vascular endothelial growth factor (VEGF) release in vitro. Bone marrow stromal cells (ST-2) were cultivated with the supernatant of granules of different sizes and at different concentrations (0-1 wt/vol % of granules) for 48 h. In addition to in vitro studies, Ca-ion release from all as cell morphology observation revealed no cytotoxic effect of the released products from all tested materials. It was found that supernatants from granules in concentrations of 1 wt/vol %enhanced the VEGF release from ST2 cells, which is important as a marker of the vascularisation ability of the glass during the bone healing process.

scholarly journals Spreading and proliferation of cultured rat bone marrow stromal cells on the surface of bioactive glass ceramics

2017 ◽  
Vol 33 (1) ◽  
pp. 48-57
Author(s):  
V. V. Kiroshka ◽  
O. V. Savvova ◽  
Yu. O. Bozhkova ◽  
I. V. Tamarina ◽  
A. I. Fesenko
Keyword(s):  
Bone Marrow ◽  
Bioactive Glass ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Glass Ceramics ◽  
Marrow Stromal Cells ◽  
Rat Bone
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